White tea (Camellia sinensis) aqueous extract extends the lifespan of fruit flies (Drosophila melanogaster) under a high-sugar diet

As the second most consumed beverage globally, tea possesses a range of health benefits. This study sought to explore the anti-aging effects of white tea ( Camellia sinensis ) aqueous extract (WTAE) through in vivo experiments conducted on fruit flies ( Drosophila melanogaster ) subjected to a high-sugar diet. The findings indicated that WTAE significantly ( P < 0.05) increased the median, mean, and maximum lifespans of the flies under high-sugar diets. At a concentration of 3.0 mg/mL, WTAE resulted in a 32% increase in the mean lifespan of female flies, while a 29% increase in male flies, compared to the high-sugar group (HSG). Furthermore, the maximum lifespan was extended by 32% in females and 22% in males, suggesting WTAE's lifespan-prolonging effect in these fruit flies. WTAE supplementation alongside the high-sugar diet significantly ( P < 0.05) improved locomotor performance and oxidative stress resistance in both male and female flies. Simultaneously, WTAE supplementation significantly ( P < 0.05) reduced MDA concentrations in the flies while concurrently increasing the enzyme activities of T-SOD and CAT. As a potential dietary agent with anti-aging properties, WTAE exhibits potential for application in functional food and nutraceutical development.