Urinary neutrophil gelatinase-associated lipocalin to monitor lupus nephritis disease activity

Hani Susianti; Jullyanny W. Wijaya; Ati Rastini; Kusworini Handono; Atma Gunawan; Handono Kalim

doi:10.4137/BMIMI.S27625

Urinary neutrophil gelatinase-associated lipocalin to monitor lupus nephritis disease activity

Hani Susianti^*
, Jullyanny W. Wijaya
, Ati Rastini
, Kusworini Handono
, Atma Gunawan
, Handono Kalim

^*Corresponding author for this work

Faculty of Medicine

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Background: This study was conducted to determine whether there is an association between urinary neutrophil gelatinase-associated lipocalin (uNGAL) and urinary transforming growth factor-β1 (uTGF-β1) with lupus nephritis (LN) disease activity.Methods: Urine samples from 18 LN patients were collected every month for six months then examined for uNGAL, uTGF-β1, and renal domain Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score.Results: The uNGAL levels were significantly different between active and inactive LN (P, 0.05). uTGF-β1 levels were not different between active and inactive LN (P. 0.05). There was a significant correlation between uNGAL levels and renal domain SLEDAI score (r = 0.417, P, 0.05). There was no correlation between uTGF-β1 levels and renal domain SLEDAI score (r = 0.031, P. 0.05).Conclusion: uNGAL is better than uTGF-β1 for differentiation of active and inactive LN. uNGAL can be considered as a biomarker to monitor LN disease activity.

Original language	English
Pages (from-to)	81-87
Number of pages	7
Journal	Biomarker Insights
Volume	10
DOIs	https://doi.org/10.4137/BMIMI.S27625
Publication status	Published - 27 Jul 2015

Keywords

Disease activity
Lupus nephritis
uNGAL
uTGF-β1

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@article{e188a66723484a748bd2dbf8000b6aad,

title = "Urinary neutrophil gelatinase-associated lipocalin to monitor lupus nephritis disease activity",

abstract = "Background: This study was conducted to determine whether there is an association between urinary neutrophil gelatinase-associated lipocalin (uNGAL) and urinary transforming growth factor-β1 (uTGF-β1) with lupus nephritis (LN) disease activity.Methods: Urine samples from 18 LN patients were collected every month for six months then examined for uNGAL, uTGF-β1, and renal domain Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score.Results: The uNGAL levels were significantly different between active and inactive LN (P, 0.05). uTGF-β1 levels were not different between active and inactive LN (P. 0.05). There was a significant correlation between uNGAL levels and renal domain SLEDAI score (r = 0.417, P, 0.05). There was no correlation between uTGF-β1 levels and renal domain SLEDAI score (r = 0.031, P. 0.05).Conclusion: uNGAL is better than uTGF-β1 for differentiation of active and inactive LN. uNGAL can be considered as a biomarker to monitor LN disease activity.",

keywords = "Disease activity, Lupus nephritis, uNGAL, uTGF-β1",

author = "Hani Susianti and Wijaya, \{Jullyanny W.\} and Ati Rastini and Kusworini Handono and Atma Gunawan and Handono Kalim",

note = "Publisher Copyright: {\textcopyright} the authors, publisher and licensee Libertas Academica Limited.",

year = "2015",

month = jul,

day = "27",

doi = "10.4137/BMIMI.S27625",

language = "English",

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journal = "Biomarker Insights",

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TY - JOUR

T1 - Urinary neutrophil gelatinase-associated lipocalin to monitor lupus nephritis disease activity

AU - Susianti, Hani

AU - Wijaya, Jullyanny W.

AU - Rastini, Ati

AU - Handono, Kusworini

AU - Gunawan, Atma

AU - Kalim, Handono

N1 - Publisher Copyright: © the authors, publisher and licensee Libertas Academica Limited.

PY - 2015/7/27

Y1 - 2015/7/27

N2 - Background: This study was conducted to determine whether there is an association between urinary neutrophil gelatinase-associated lipocalin (uNGAL) and urinary transforming growth factor-β1 (uTGF-β1) with lupus nephritis (LN) disease activity.Methods: Urine samples from 18 LN patients were collected every month for six months then examined for uNGAL, uTGF-β1, and renal domain Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score.Results: The uNGAL levels were significantly different between active and inactive LN (P, 0.05). uTGF-β1 levels were not different between active and inactive LN (P. 0.05). There was a significant correlation between uNGAL levels and renal domain SLEDAI score (r = 0.417, P, 0.05). There was no correlation between uTGF-β1 levels and renal domain SLEDAI score (r = 0.031, P. 0.05).Conclusion: uNGAL is better than uTGF-β1 for differentiation of active and inactive LN. uNGAL can be considered as a biomarker to monitor LN disease activity.

AB - Background: This study was conducted to determine whether there is an association between urinary neutrophil gelatinase-associated lipocalin (uNGAL) and urinary transforming growth factor-β1 (uTGF-β1) with lupus nephritis (LN) disease activity.Methods: Urine samples from 18 LN patients were collected every month for six months then examined for uNGAL, uTGF-β1, and renal domain Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score.Results: The uNGAL levels were significantly different between active and inactive LN (P, 0.05). uTGF-β1 levels were not different between active and inactive LN (P. 0.05). There was a significant correlation between uNGAL levels and renal domain SLEDAI score (r = 0.417, P, 0.05). There was no correlation between uTGF-β1 levels and renal domain SLEDAI score (r = 0.031, P. 0.05).Conclusion: uNGAL is better than uTGF-β1 for differentiation of active and inactive LN. uNGAL can be considered as a biomarker to monitor LN disease activity.

KW - Disease activity

KW - Lupus nephritis

KW - uNGAL

KW - uTGF-β1

UR - https://www.scopus.com/pages/publications/84941000151

U2 - 10.4137/BMIMI.S27625

DO - 10.4137/BMIMI.S27625

M3 - Article

AN - SCOPUS:84941000151

SN - 1177-2719

VL - 10

SP - 81

EP - 87

JO - Biomarker Insights

JF - Biomarker Insights

ER -

Urinary neutrophil gelatinase-associated lipocalin to monitor lupus nephritis disease activity

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