The role of vitamin D3supplementation to transforming growth factor β1 and tumor necrosis factor α levels in steroid resistant nephrotic syndrome

Susanti Susanti; Krisni Subandiyah; Husnul Khotimah

doi:10.1063/5.0052610

The role of vitamin D₃supplementation to transforming growth factor β1 and tumor necrosis factor α levels in steroid resistant nephrotic syndrome

Susanti Susanti^*
, Krisni Subandiyah
, Husnul Khotimah

^*Corresponding author for this work

Faculty of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Citations (Scopus)

Abstract

Nephrotic syndrome, the most common kidney disease in children, has been associated with transforming growth factor β1 (TGF-β1) and tumor necrosis factor a (TNF-α). This study aimed to assess the role of vitamin D3 supplementation to TGF-β1 and TNF-α levels in steroid-resistant nephrotic syndrome (SNRS). This research was an experimental study involving 32 subjects divided into two groups. Each group was given a placebo and vitamin D3 for four weeks. Peripheral blood was taken before and after treatment. In the placebo group, there were significant decrease in 25(OH)D, increase in TGF-β1, and increase in TNF-α after treatment (p < 0.05). In the vitamin D3 supplementation group, there were significant increase in 25(OH)D, decrease in TGF-β1, and decrease in TNF-α (p < 0.05). The increase in 25(OH)D had correlation with the decrease in TGF-β1 (r =-0.593; p = 0.000) and the decrease in TNF-α (r =-0.782; p = 0.000). 0ur data indicated that vitamin D3 supplementation could increase 25(OH)D, decrease TGF-β1 and TNF-α. The decrease in TGF-β1, and TNF-α was negatively correlated with the increase in 25(OH)D in SRNS.

Original language	English
Title of host publication	International Conference on Life Sciences and Technology, ICoLiST 2020
Editors	Ahmad Taufiq, Hendra Susanto, Hadi Nur, Muhammad Aziz, Acharee Suksuwan, Chen Siang Ng, Khairunadwa Binti Jemon, Mohamad Amin, Markus Diantoro, Nandang Mufti, Nik Ahmad Nizam Nik Malek, I. Ching Wang, Sunaryono, Siti Zubaidah, Aulanni'am, Indra Wibowo, Adeodatus Yuda Handaya
Publisher	American Institute of Physics Inc.
ISBN (Electronic)	9780735440968
DOIs	https://doi.org/10.1063/5.0052610
Publication status	Published - 25 May 2021
Event	3rd International Conference on Life Sciences and Technology, ICoLiST 2020 - Malang, Indonesia Duration: 29 Sept 2020 → …

Publication series

Name	AIP Conference Proceedings
Volume	2353
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	3rd International Conference on Life Sciences and Technology, ICoLiST 2020
Country/Territory	Indonesia
City	Malang
Period	29/09/20 → …

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1063/5.0052610

Cite this

Susanti, S., Subandiyah, K., & Khotimah, H. (2021). The role of vitamin D₃supplementation to transforming growth factor β1 and tumor necrosis factor α levels in steroid resistant nephrotic syndrome. In A. Taufiq, H. Susanto, H. Nur, M. Aziz, A. Suksuwan, C. S. Ng, K. B. Jemon, M. Amin, M. Diantoro, N. Mufti, N. A. N. N. Malek, I. C. Wang, Sunaryono, S. Zubaidah, Aulanni'am, I. Wibowo, & A. Y. Handaya (Eds.), International Conference on Life Sciences and Technology, ICoLiST 2020 Article 030064 (AIP Conference Proceedings; Vol. 2353). American Institute of Physics Inc.. https://doi.org/10.1063/5.0052610

Susanti, Susanti ; Subandiyah, Krisni ; Khotimah, Husnul. / The role of vitamin D₃supplementation to transforming growth factor β1 and tumor necrosis factor α levels in steroid resistant nephrotic syndrome. International Conference on Life Sciences and Technology, ICoLiST 2020. editor / Ahmad Taufiq ; Hendra Susanto ; Hadi Nur ; Muhammad Aziz ; Acharee Suksuwan ; Chen Siang Ng ; Khairunadwa Binti Jemon ; Mohamad Amin ; Markus Diantoro ; Nandang Mufti ; Nik Ahmad Nizam Nik Malek ; I. Ching Wang ; Sunaryono ; Siti Zubaidah ; Aulanni'am ; Indra Wibowo ; Adeodatus Yuda Handaya. American Institute of Physics Inc., 2021. (AIP Conference Proceedings).

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title = "The role of vitamin D3supplementation to transforming growth factor β1 and tumor necrosis factor α levels in steroid resistant nephrotic syndrome",

abstract = "Nephrotic syndrome, the most common kidney disease in children, has been associated with transforming growth factor β1 (TGF-β1) and tumor necrosis factor a (TNF-α). This study aimed to assess the role of vitamin D3 supplementation to TGF-β1 and TNF-α levels in steroid-resistant nephrotic syndrome (SNRS). This research was an experimental study involving 32 subjects divided into two groups. Each group was given a placebo and vitamin D3 for four weeks. Peripheral blood was taken before and after treatment. In the placebo group, there were significant decrease in 25(OH)D, increase in TGF-β1, and increase in TNF-α after treatment (p < 0.05). In the vitamin D3 supplementation group, there were significant increase in 25(OH)D, decrease in TGF-β1, and decrease in TNF-α (p < 0.05). The increase in 25(OH)D had correlation with the decrease in TGF-β1 (r =-0.593; p = 0.000) and the decrease in TNF-α (r =-0.782; p = 0.000). 0ur data indicated that vitamin D3 supplementation could increase 25(OH)D, decrease TGF-β1 and TNF-α. The decrease in TGF-β1, and TNF-α was negatively correlated with the increase in 25(OH)D in SRNS.",

author = "Susanti Susanti and Krisni Subandiyah and Husnul Khotimah",

note = "Publisher Copyright: {\textcopyright} 2021 Author(s).; 3rd International Conference on Life Sciences and Technology, ICoLiST 2020 ; Conference date: 29-09-2020",

year = "2021",

month = may,

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doi = "10.1063/5.0052610",

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editor = "Ahmad Taufiq and Hendra Susanto and Hadi Nur and Muhammad Aziz and Acharee Suksuwan and Ng, \{Chen Siang\} and Jemon, \{Khairunadwa Binti\} and Mohamad Amin and Markus Diantoro and Nandang Mufti and Malek, \{Nik Ahmad Nizam Nik\} and Wang, \{I. Ching\} and Sunaryono and Siti Zubaidah and Aulanni'am and Indra Wibowo and Handaya, \{Adeodatus Yuda\}",

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Susanti, S, Subandiyah, K & Khotimah, H 2021, The role of vitamin D₃supplementation to transforming growth factor β1 and tumor necrosis factor α levels in steroid resistant nephrotic syndrome. in A Taufiq, H Susanto, H Nur, M Aziz, A Suksuwan, CS Ng, KB Jemon, M Amin, M Diantoro, N Mufti, NANN Malek, IC Wang, Sunaryono, S Zubaidah, Aulanni'am, I Wibowo & AY Handaya (eds), International Conference on Life Sciences and Technology, ICoLiST 2020., 030064, AIP Conference Proceedings, vol. 2353, American Institute of Physics Inc., 3rd International Conference on Life Sciences and Technology, ICoLiST 2020, Malang, Indonesia, 29/09/20. https://doi.org/10.1063/5.0052610

The role of vitamin D₃supplementation to transforming growth factor β1 and tumor necrosis factor α levels in steroid resistant nephrotic syndrome. / Susanti, Susanti; Subandiyah, Krisni; Khotimah, Husnul.
International Conference on Life Sciences and Technology, ICoLiST 2020. ed. / Ahmad Taufiq; Hendra Susanto; Hadi Nur; Muhammad Aziz; Acharee Suksuwan; Chen Siang Ng; Khairunadwa Binti Jemon; Mohamad Amin; Markus Diantoro; Nandang Mufti; Nik Ahmad Nizam Nik Malek; I. Ching Wang; Sunaryono; Siti Zubaidah; Aulanni'am; Indra Wibowo; Adeodatus Yuda Handaya. American Institute of Physics Inc., 2021. 030064 (AIP Conference Proceedings; Vol. 2353).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - The role of vitamin D3supplementation to transforming growth factor β1 and tumor necrosis factor α levels in steroid resistant nephrotic syndrome

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AU - Subandiyah, Krisni

AU - Khotimah, Husnul

PY - 2021/5/25

Y1 - 2021/5/25

N2 - Nephrotic syndrome, the most common kidney disease in children, has been associated with transforming growth factor β1 (TGF-β1) and tumor necrosis factor a (TNF-α). This study aimed to assess the role of vitamin D3 supplementation to TGF-β1 and TNF-α levels in steroid-resistant nephrotic syndrome (SNRS). This research was an experimental study involving 32 subjects divided into two groups. Each group was given a placebo and vitamin D3 for four weeks. Peripheral blood was taken before and after treatment. In the placebo group, there were significant decrease in 25(OH)D, increase in TGF-β1, and increase in TNF-α after treatment (p < 0.05). In the vitamin D3 supplementation group, there were significant increase in 25(OH)D, decrease in TGF-β1, and decrease in TNF-α (p < 0.05). The increase in 25(OH)D had correlation with the decrease in TGF-β1 (r =-0.593; p = 0.000) and the decrease in TNF-α (r =-0.782; p = 0.000). 0ur data indicated that vitamin D3 supplementation could increase 25(OH)D, decrease TGF-β1 and TNF-α. The decrease in TGF-β1, and TNF-α was negatively correlated with the increase in 25(OH)D in SRNS.

AB - Nephrotic syndrome, the most common kidney disease in children, has been associated with transforming growth factor β1 (TGF-β1) and tumor necrosis factor a (TNF-α). This study aimed to assess the role of vitamin D3 supplementation to TGF-β1 and TNF-α levels in steroid-resistant nephrotic syndrome (SNRS). This research was an experimental study involving 32 subjects divided into two groups. Each group was given a placebo and vitamin D3 for four weeks. Peripheral blood was taken before and after treatment. In the placebo group, there were significant decrease in 25(OH)D, increase in TGF-β1, and increase in TNF-α after treatment (p < 0.05). In the vitamin D3 supplementation group, there were significant increase in 25(OH)D, decrease in TGF-β1, and decrease in TNF-α (p < 0.05). The increase in 25(OH)D had correlation with the decrease in TGF-β1 (r =-0.593; p = 0.000) and the decrease in TNF-α (r =-0.782; p = 0.000). 0ur data indicated that vitamin D3 supplementation could increase 25(OH)D, decrease TGF-β1 and TNF-α. The decrease in TGF-β1, and TNF-α was negatively correlated with the increase in 25(OH)D in SRNS.

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M3 - Conference contribution

AN - SCOPUS:85107289336

T3 - AIP Conference Proceedings

BT - International Conference on Life Sciences and Technology, ICoLiST 2020

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A2 - Susanto, Hendra

A2 - Nur, Hadi

A2 - Aziz, Muhammad

A2 - Suksuwan, Acharee

A2 - Ng, Chen Siang

A2 - Jemon, Khairunadwa Binti

A2 - Amin, Mohamad

A2 - Diantoro, Markus

A2 - Mufti, Nandang

A2 - Malek, Nik Ahmad Nizam Nik

A2 - Wang, I. Ching

A2 - Sunaryono, null

A2 - Zubaidah, Siti

A2 - Aulanni'am, null

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Susanti S, Subandiyah K, Khotimah H. The role of vitamin D₃supplementation to transforming growth factor β1 and tumor necrosis factor α levels in steroid resistant nephrotic syndrome. In Taufiq A, Susanto H, Nur H, Aziz M, Suksuwan A, Ng CS, Jemon KB, Amin M, Diantoro M, Mufti N, Malek NANN, Wang IC, Sunaryono, Zubaidah S, Aulanni'am, Wibowo I, Handaya AY, editors, International Conference on Life Sciences and Technology, ICoLiST 2020. American Institute of Physics Inc. 2021. 030064. (AIP Conference Proceedings). doi: 10.1063/5.0052610