The role of tumor necrosis factor-α and Interleukin-17 with severity of lung damage in paediatric tuberculosis

Anita Febriana; Ery Olivianto; Husnul Khotimah

doi:10.1063/5.0052772

The role of tumor necrosis factor-α and Interleukin-17 with severity of lung damage in paediatric tuberculosis

Anita Febriana^*
, Ery Olivianto
, Husnul Khotimah

^*Corresponding author for this work

Faculty of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Citation (Scopus)

Abstract

Tuberculosis (TB) caused by infection of Mycobacterium tuberculosis (MTb) has a complex immunological response that leading to a variety of lung pathology, as reflected on Chest X-ray (CXR) imaging. Tumor Necrosis Factor-a (TNF-α) and Interleukin-17 (IL-17) are also pro-inflammatory cytokines secreted as a response of MTb infection. Both have pleiotropic effects and excessive expressions are associated with lung damage. This study aims to determine the correlation between levels of TNF-α and IL-17 based on lung damage from CXR in paediatric TB. This is a cross-sectional study. The subjects include 38 TB patients divided into 3 groups; mild, moderate, and severe lung damage based on CXR, from January 2019 to July 2020. Plasma TNF-α and IL-17 levels measured using ELISA then compared to each group. There is a significant difference in TNF-α levels between mild vs moderate (p = 0.002), mild vs severe (p = 0.000), and moderate vs severe lung damage (p = 0.001). A positive correlation was also found between TNF-α levels and lung damage (p = 0.000, r = 0.796), whereas IL-17 shows no significant difference (p = 0.538). Increasing TNF-α level, but not IL-17, is associated with severity of lung damage in paediatric TB.

Original language	English
Title of host publication	International Conference on Life Sciences and Technology, ICoLiST 2020
Editors	Ahmad Taufiq, Hendra Susanto, Hadi Nur, Muhammad Aziz, Acharee Suksuwan, Chen Siang Ng, Khairunadwa Binti Jemon, Mohamad Amin, Markus Diantoro, Nandang Mufti, Nik Ahmad Nizam Nik Malek, I. Ching Wang, Sunaryono, Siti Zubaidah, Aulanni'am, Indra Wibowo, Adeodatus Yuda Handaya
Publisher	American Institute of Physics Inc.
ISBN (Electronic)	9780735440968
DOIs	https://doi.org/10.1063/5.0052772
Publication status	Published - 25 May 2021
Event	3rd International Conference on Life Sciences and Technology, ICoLiST 2020 - Malang, Indonesia Duration: 29 Sept 2020 → …

Publication series

Name	AIP Conference Proceedings
Volume	2353
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	3rd International Conference on Life Sciences and Technology, ICoLiST 2020
Country/Territory	Indonesia
City	Malang
Period	29/09/20 → …

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1063/5.0052772

Cite this

Febriana, A., Olivianto, E., & Khotimah, H. (2021). The role of tumor necrosis factor-α and Interleukin-17 with severity of lung damage in paediatric tuberculosis. In A. Taufiq, H. Susanto, H. Nur, M. Aziz, A. Suksuwan, C. S. Ng, K. B. Jemon, M. Amin, M. Diantoro, N. Mufti, N. A. N. N. Malek, I. C. Wang, Sunaryono, S. Zubaidah, Aulanni'am, I. Wibowo, & A. Y. Handaya (Eds.), International Conference on Life Sciences and Technology, ICoLiST 2020 Article 030085 (AIP Conference Proceedings; Vol. 2353). American Institute of Physics Inc.. https://doi.org/10.1063/5.0052772

Febriana, Anita ; Olivianto, Ery ; Khotimah, Husnul. / The role of tumor necrosis factor-α and Interleukin-17 with severity of lung damage in paediatric tuberculosis. International Conference on Life Sciences and Technology, ICoLiST 2020. editor / Ahmad Taufiq ; Hendra Susanto ; Hadi Nur ; Muhammad Aziz ; Acharee Suksuwan ; Chen Siang Ng ; Khairunadwa Binti Jemon ; Mohamad Amin ; Markus Diantoro ; Nandang Mufti ; Nik Ahmad Nizam Nik Malek ; I. Ching Wang ; Sunaryono ; Siti Zubaidah ; Aulanni'am ; Indra Wibowo ; Adeodatus Yuda Handaya. American Institute of Physics Inc., 2021. (AIP Conference Proceedings).

@inproceedings{a893898b61c244539a8de091eab4ac18,

title = "The role of tumor necrosis factor-α and Interleukin-17 with severity of lung damage in paediatric tuberculosis",

abstract = "Tuberculosis (TB) caused by infection of Mycobacterium tuberculosis (MTb) has a complex immunological response that leading to a variety of lung pathology, as reflected on Chest X-ray (CXR) imaging. Tumor Necrosis Factor-a (TNF-α) and Interleukin-17 (IL-17) are also pro-inflammatory cytokines secreted as a response of MTb infection. Both have pleiotropic effects and excessive expressions are associated with lung damage. This study aims to determine the correlation between levels of TNF-α and IL-17 based on lung damage from CXR in paediatric TB. This is a cross-sectional study. The subjects include 38 TB patients divided into 3 groups; mild, moderate, and severe lung damage based on CXR, from January 2019 to July 2020. Plasma TNF-α and IL-17 levels measured using ELISA then compared to each group. There is a significant difference in TNF-α levels between mild vs moderate (p = 0.002), mild vs severe (p = 0.000), and moderate vs severe lung damage (p = 0.001). A positive correlation was also found between TNF-α levels and lung damage (p = 0.000, r = 0.796), whereas IL-17 shows no significant difference (p = 0.538). Increasing TNF-α level, but not IL-17, is associated with severity of lung damage in paediatric TB.",

author = "Anita Febriana and Ery Olivianto and Husnul Khotimah",

note = "Publisher Copyright: {\textcopyright} 2021 Author(s).; 3rd International Conference on Life Sciences and Technology, ICoLiST 2020 ; Conference date: 29-09-2020",

year = "2021",

month = may,

day = "25",

doi = "10.1063/5.0052772",

language = "English",

series = "AIP Conference Proceedings",

publisher = "American Institute of Physics Inc.",

editor = "Ahmad Taufiq and Hendra Susanto and Hadi Nur and Muhammad Aziz and Acharee Suksuwan and Ng, \{Chen Siang\} and Jemon, \{Khairunadwa Binti\} and Mohamad Amin and Markus Diantoro and Nandang Mufti and Malek, \{Nik Ahmad Nizam Nik\} and Wang, \{I. Ching\} and Sunaryono and Siti Zubaidah and Aulanni'am and Indra Wibowo and Handaya, \{Adeodatus Yuda\}",

booktitle = "International Conference on Life Sciences and Technology, ICoLiST 2020",

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Febriana, A, Olivianto, E & Khotimah, H 2021, The role of tumor necrosis factor-α and Interleukin-17 with severity of lung damage in paediatric tuberculosis. in A Taufiq, H Susanto, H Nur, M Aziz, A Suksuwan, CS Ng, KB Jemon, M Amin, M Diantoro, N Mufti, NANN Malek, IC Wang, Sunaryono, S Zubaidah, Aulanni'am, I Wibowo & AY Handaya (eds), International Conference on Life Sciences and Technology, ICoLiST 2020., 030085, AIP Conference Proceedings, vol. 2353, American Institute of Physics Inc., 3rd International Conference on Life Sciences and Technology, ICoLiST 2020, Malang, Indonesia, 29/09/20. https://doi.org/10.1063/5.0052772

The role of tumor necrosis factor-α and Interleukin-17 with severity of lung damage in paediatric tuberculosis. / Febriana, Anita; Olivianto, Ery; Khotimah, Husnul.
International Conference on Life Sciences and Technology, ICoLiST 2020. ed. / Ahmad Taufiq; Hendra Susanto; Hadi Nur; Muhammad Aziz; Acharee Suksuwan; Chen Siang Ng; Khairunadwa Binti Jemon; Mohamad Amin; Markus Diantoro; Nandang Mufti; Nik Ahmad Nizam Nik Malek; I. Ching Wang; Sunaryono; Siti Zubaidah; Aulanni'am; Indra Wibowo; Adeodatus Yuda Handaya. American Institute of Physics Inc., 2021. 030085 (AIP Conference Proceedings; Vol. 2353).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - The role of tumor necrosis factor-α and Interleukin-17 with severity of lung damage in paediatric tuberculosis

AU - Febriana, Anita

AU - Olivianto, Ery

AU - Khotimah, Husnul

PY - 2021/5/25

Y1 - 2021/5/25

N2 - Tuberculosis (TB) caused by infection of Mycobacterium tuberculosis (MTb) has a complex immunological response that leading to a variety of lung pathology, as reflected on Chest X-ray (CXR) imaging. Tumor Necrosis Factor-a (TNF-α) and Interleukin-17 (IL-17) are also pro-inflammatory cytokines secreted as a response of MTb infection. Both have pleiotropic effects and excessive expressions are associated with lung damage. This study aims to determine the correlation between levels of TNF-α and IL-17 based on lung damage from CXR in paediatric TB. This is a cross-sectional study. The subjects include 38 TB patients divided into 3 groups; mild, moderate, and severe lung damage based on CXR, from January 2019 to July 2020. Plasma TNF-α and IL-17 levels measured using ELISA then compared to each group. There is a significant difference in TNF-α levels between mild vs moderate (p = 0.002), mild vs severe (p = 0.000), and moderate vs severe lung damage (p = 0.001). A positive correlation was also found between TNF-α levels and lung damage (p = 0.000, r = 0.796), whereas IL-17 shows no significant difference (p = 0.538). Increasing TNF-α level, but not IL-17, is associated with severity of lung damage in paediatric TB.

AB - Tuberculosis (TB) caused by infection of Mycobacterium tuberculosis (MTb) has a complex immunological response that leading to a variety of lung pathology, as reflected on Chest X-ray (CXR) imaging. Tumor Necrosis Factor-a (TNF-α) and Interleukin-17 (IL-17) are also pro-inflammatory cytokines secreted as a response of MTb infection. Both have pleiotropic effects and excessive expressions are associated with lung damage. This study aims to determine the correlation between levels of TNF-α and IL-17 based on lung damage from CXR in paediatric TB. This is a cross-sectional study. The subjects include 38 TB patients divided into 3 groups; mild, moderate, and severe lung damage based on CXR, from January 2019 to July 2020. Plasma TNF-α and IL-17 levels measured using ELISA then compared to each group. There is a significant difference in TNF-α levels between mild vs moderate (p = 0.002), mild vs severe (p = 0.000), and moderate vs severe lung damage (p = 0.001). A positive correlation was also found between TNF-α levels and lung damage (p = 0.000, r = 0.796), whereas IL-17 shows no significant difference (p = 0.538). Increasing TNF-α level, but not IL-17, is associated with severity of lung damage in paediatric TB.

UR - https://www.scopus.com/pages/publications/85107271625

U2 - 10.1063/5.0052772

DO - 10.1063/5.0052772

M3 - Conference contribution

AN - SCOPUS:85107271625

T3 - AIP Conference Proceedings

BT - International Conference on Life Sciences and Technology, ICoLiST 2020

A2 - Taufiq, Ahmad

A2 - Susanto, Hendra

A2 - Nur, Hadi

A2 - Aziz, Muhammad

A2 - Suksuwan, Acharee

A2 - Ng, Chen Siang

A2 - Jemon, Khairunadwa Binti

A2 - Amin, Mohamad

A2 - Diantoro, Markus

A2 - Mufti, Nandang

A2 - Malek, Nik Ahmad Nizam Nik

A2 - Wang, I. Ching

A2 - Sunaryono, null

A2 - Zubaidah, Siti

A2 - Aulanni'am, null

A2 - Wibowo, Indra

A2 - Handaya, Adeodatus Yuda

PB - American Institute of Physics Inc.

T2 - 3rd International Conference on Life Sciences and Technology, ICoLiST 2020

Y2 - 29 September 2020

ER -

Febriana A, Olivianto E, Khotimah H. The role of tumor necrosis factor-α and Interleukin-17 with severity of lung damage in paediatric tuberculosis. In Taufiq A, Susanto H, Nur H, Aziz M, Suksuwan A, Ng CS, Jemon KB, Amin M, Diantoro M, Mufti N, Malek NANN, Wang IC, Sunaryono, Zubaidah S, Aulanni'am, Wibowo I, Handaya AY, editors, International Conference on Life Sciences and Technology, ICoLiST 2020. American Institute of Physics Inc. 2021. 030085. (AIP Conference Proceedings). doi: 10.1063/5.0052772

The role of tumor necrosis factor-α and Interleukin-17 with severity of lung damage in paediatric tuberculosis

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