The role of Moringa oliefera -Albumin combination as a traditional medicine to control the development of SDF-1 and TER-119+VLA-4+ in diabetes mice models

Noviana Dwi Lestari; Suherr Khalleefah; Sapti Puspitarini; Aris Soewondo; Muhamin Rifa'I

doi:10.1063/1.5125552

The role of Moringa oliefera -Albumin combination as a traditional medicine to control the development of SDF-1 and TER-119⁺VLA-4⁺ in diabetes mice models

Noviana Dwi Lestari
, Suherr Khalleefah
, Sapti Puspitarini
, Widodo
, Aris Soewondo
, Muhamin Rifa'I^*

^*Corresponding author for this work

Faculty of Mathematics and Natural Sciences

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Citations (Scopus)

Abstract

Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia. Hyperglycemia in DM leads to bone marrow dysfunction in the hematopoiesis process of hematopoietic stem cells (HSC). The objective of this research was to analyze the advantage of Moringa oliefera-Albumin (MA) combination to control the development of SDF-1 and TER-119⁺VLA-4⁺ in bone marrow. Streptozotocin was used to induce diabetes in BALB/c mice. MA was orally administered during 14 days at dose 1 (50% M: 50% A), dose 2 (75% M: 25% A) and dose 3 (25% M: 75% A). Bone marrow cells from mice were isolated on day 15 after treatment, and the profile of SDF-1 and TER-119⁺VLA-4⁺ cells were analyzed by flow cytometry. The data were statistically analyzed with one way ANOVA (p ≤ 0.05) and Tukey test using SPSS version 16 for Windows. The results showed that all the doses of MA combination could significantly decrease the development of SDF-1 while only dose 2 (75% M: 25% A) effective to increase the development of TER-119⁺VLA-4⁺. In conclusions, MA combination has a role in controlling the development of SDF-1 and TER-119⁺VLA-4⁺ at certain dose. Based on the results, we assumed that MA might be one of a good candidate as therapeutic agent for diabetes mellitus.

Original language	English
Title of host publication	Proceedings of the 2nd International Conference on Biosciences and Medical Engineering, ICBME 2019
Subtitle of host publication	Towards Innovative Research and Cross-Disciplinary Collaborations
Editors	Naji Arafat Mahat, Roswanira Ab. Wahab, Fahrul Zaman Huyop, Aemi Syazwani Abdul Keyon, Nursyafreena Binti Attan, Sheela Chandren, Ida Bagus Wayan Gunam
Publisher	American Institute of Physics Inc.
ISBN (Electronic)	9780735419001
DOIs	https://doi.org/10.1063/1.5125552
Publication status	Published - 6 Sept 2019
Event	2nd International Conference on Biosciences and Medical Engineering 2019: Towards Innovative Research and Cross-Disciplinary Collaborations, ICBME 2019 - Bali, Indonesia Duration: 11 Apr 2019 → 12 Apr 2019

Publication series

Name	AIP Conference Proceedings
Volume	2155
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	2nd International Conference on Biosciences and Medical Engineering 2019: Towards Innovative Research and Cross-Disciplinary Collaborations, ICBME 2019
Country/Territory	Indonesia
City	Bali
Period	11/04/19 → 12/04/19

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1063/1.5125552

Cite this

Lestari, N. D., Khalleefah, S., Puspitarini, S., Widodo , Soewondo, A., & Rifa'I, M. (2019). The role of Moringa oliefera -Albumin combination as a traditional medicine to control the development of SDF-1 and TER-119⁺VLA-4⁺ in diabetes mice models. In N. A. Mahat, R. A. Wahab, F. Z. Huyop, A. S. A. Keyon, N. B. Attan, S. Chandren, & I. B. W. Gunam (Eds.), Proceedings of the 2nd International Conference on Biosciences and Medical Engineering, ICBME 2019: Towards Innovative Research and Cross-Disciplinary Collaborations Article 020048 (AIP Conference Proceedings; Vol. 2155). American Institute of Physics Inc.. https://doi.org/10.1063/1.5125552

Lestari, Noviana Dwi ; Khalleefah, Suherr ; Puspitarini, Sapti et al. / The role of Moringa oliefera -Albumin combination as a traditional medicine to control the development of SDF-1 and TER-119⁺VLA-4⁺ in diabetes mice models. Proceedings of the 2nd International Conference on Biosciences and Medical Engineering, ICBME 2019: Towards Innovative Research and Cross-Disciplinary Collaborations. editor / Naji Arafat Mahat ; Roswanira Ab. Wahab ; Fahrul Zaman Huyop ; Aemi Syazwani Abdul Keyon ; Nursyafreena Binti Attan ; Sheela Chandren ; Ida Bagus Wayan Gunam. American Institute of Physics Inc., 2019. (AIP Conference Proceedings).

@inproceedings{7cbcc4b5deac4038994d1285b08176d8,

title = "The role of Moringa oliefera -Albumin combination as a traditional medicine to control the development of SDF-1 and TER-119+VLA-4+ in diabetes mice models",

abstract = "Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia. Hyperglycemia in DM leads to bone marrow dysfunction in the hematopoiesis process of hematopoietic stem cells (HSC). The objective of this research was to analyze the advantage of Moringa oliefera-Albumin (MA) combination to control the development of SDF-1 and TER-119+VLA-4+ in bone marrow. Streptozotocin was used to induce diabetes in BALB/c mice. MA was orally administered during 14 days at dose 1 (50\% M: 50\% A), dose 2 (75\% M: 25\% A) and dose 3 (25\% M: 75\% A). Bone marrow cells from mice were isolated on day 15 after treatment, and the profile of SDF-1 and TER-119+VLA-4+ cells were analyzed by flow cytometry. The data were statistically analyzed with one way ANOVA (p ≤ 0.05) and Tukey test using SPSS version 16 for Windows. The results showed that all the doses of MA combination could significantly decrease the development of SDF-1 while only dose 2 (75\% M: 25\% A) effective to increase the development of TER-119+VLA-4+. In conclusions, MA combination has a role in controlling the development of SDF-1 and TER-119+VLA-4+ at certain dose. Based on the results, we assumed that MA might be one of a good candidate as therapeutic agent for diabetes mellitus.",

author = "Lestari, \{Noviana Dwi\} and Suherr Khalleefah and Sapti Puspitarini and Widodo and Aris Soewondo and Muhamin Rifa'I",

note = "Publisher Copyright: {\textcopyright} 2019 Author(s).; 2nd International Conference on Biosciences and Medical Engineering 2019: Towards Innovative Research and Cross-Disciplinary Collaborations, ICBME 2019 ; Conference date: 11-04-2019 Through 12-04-2019",

year = "2019",

month = sep,

day = "6",

doi = "10.1063/1.5125552",

language = "English",

series = "AIP Conference Proceedings",

publisher = "American Institute of Physics Inc.",

editor = "Mahat, \{Naji Arafat\} and Wahab, \{Roswanira Ab.\} and Huyop, \{Fahrul Zaman\} and Keyon, \{Aemi Syazwani Abdul\} and Attan, \{Nursyafreena Binti\} and Sheela Chandren and Gunam, \{Ida Bagus Wayan\}",

booktitle = "Proceedings of the 2nd International Conference on Biosciences and Medical Engineering, ICBME 2019",

}

Lestari, ND, Khalleefah, S, Puspitarini, S, Widodo, , Soewondo, A & Rifa'I, M 2019, The role of Moringa oliefera -Albumin combination as a traditional medicine to control the development of SDF-1 and TER-119⁺VLA-4⁺ in diabetes mice models. in NA Mahat, RA Wahab, FZ Huyop, ASA Keyon, NB Attan, S Chandren & IBW Gunam (eds), Proceedings of the 2nd International Conference on Biosciences and Medical Engineering, ICBME 2019: Towards Innovative Research and Cross-Disciplinary Collaborations., 020048, AIP Conference Proceedings, vol. 2155, American Institute of Physics Inc., 2nd International Conference on Biosciences and Medical Engineering 2019: Towards Innovative Research and Cross-Disciplinary Collaborations, ICBME 2019, Bali, Indonesia, 11/04/19. https://doi.org/10.1063/1.5125552

The role of Moringa oliefera -Albumin combination as a traditional medicine to control the development of SDF-1 and TER-119⁺VLA-4⁺ in diabetes mice models. / Lestari, Noviana Dwi; Khalleefah, Suherr; Puspitarini, Sapti et al.
Proceedings of the 2nd International Conference on Biosciences and Medical Engineering, ICBME 2019: Towards Innovative Research and Cross-Disciplinary Collaborations. ed. / Naji Arafat Mahat; Roswanira Ab. Wahab; Fahrul Zaman Huyop; Aemi Syazwani Abdul Keyon; Nursyafreena Binti Attan; Sheela Chandren; Ida Bagus Wayan Gunam. American Institute of Physics Inc., 2019. 020048 (AIP Conference Proceedings; Vol. 2155).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - The role of Moringa oliefera -Albumin combination as a traditional medicine to control the development of SDF-1 and TER-119+VLA-4+ in diabetes mice models

AU - Lestari, Noviana Dwi

AU - Khalleefah, Suherr

AU - Puspitarini, Sapti

AU - Widodo,

AU - Soewondo, Aris

AU - Rifa'I, Muhamin

PY - 2019/9/6

Y1 - 2019/9/6

N2 - Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia. Hyperglycemia in DM leads to bone marrow dysfunction in the hematopoiesis process of hematopoietic stem cells (HSC). The objective of this research was to analyze the advantage of Moringa oliefera-Albumin (MA) combination to control the development of SDF-1 and TER-119+VLA-4+ in bone marrow. Streptozotocin was used to induce diabetes in BALB/c mice. MA was orally administered during 14 days at dose 1 (50% M: 50% A), dose 2 (75% M: 25% A) and dose 3 (25% M: 75% A). Bone marrow cells from mice were isolated on day 15 after treatment, and the profile of SDF-1 and TER-119+VLA-4+ cells were analyzed by flow cytometry. The data were statistically analyzed with one way ANOVA (p ≤ 0.05) and Tukey test using SPSS version 16 for Windows. The results showed that all the doses of MA combination could significantly decrease the development of SDF-1 while only dose 2 (75% M: 25% A) effective to increase the development of TER-119+VLA-4+. In conclusions, MA combination has a role in controlling the development of SDF-1 and TER-119+VLA-4+ at certain dose. Based on the results, we assumed that MA might be one of a good candidate as therapeutic agent for diabetes mellitus.

AB - Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia. Hyperglycemia in DM leads to bone marrow dysfunction in the hematopoiesis process of hematopoietic stem cells (HSC). The objective of this research was to analyze the advantage of Moringa oliefera-Albumin (MA) combination to control the development of SDF-1 and TER-119+VLA-4+ in bone marrow. Streptozotocin was used to induce diabetes in BALB/c mice. MA was orally administered during 14 days at dose 1 (50% M: 50% A), dose 2 (75% M: 25% A) and dose 3 (25% M: 75% A). Bone marrow cells from mice were isolated on day 15 after treatment, and the profile of SDF-1 and TER-119+VLA-4+ cells were analyzed by flow cytometry. The data were statistically analyzed with one way ANOVA (p ≤ 0.05) and Tukey test using SPSS version 16 for Windows. The results showed that all the doses of MA combination could significantly decrease the development of SDF-1 while only dose 2 (75% M: 25% A) effective to increase the development of TER-119+VLA-4+. In conclusions, MA combination has a role in controlling the development of SDF-1 and TER-119+VLA-4+ at certain dose. Based on the results, we assumed that MA might be one of a good candidate as therapeutic agent for diabetes mellitus.

UR - https://www.scopus.com/pages/publications/85072599073

U2 - 10.1063/1.5125552

DO - 10.1063/1.5125552

M3 - Conference contribution

AN - SCOPUS:85072599073

T3 - AIP Conference Proceedings

BT - Proceedings of the 2nd International Conference on Biosciences and Medical Engineering, ICBME 2019

A2 - Mahat, Naji Arafat

A2 - Wahab, Roswanira Ab.

A2 - Huyop, Fahrul Zaman

A2 - Keyon, Aemi Syazwani Abdul

A2 - Attan, Nursyafreena Binti

A2 - Chandren, Sheela

A2 - Gunam, Ida Bagus Wayan

PB - American Institute of Physics Inc.

T2 - 2nd International Conference on Biosciences and Medical Engineering 2019: Towards Innovative Research and Cross-Disciplinary Collaborations, ICBME 2019

Y2 - 11 April 2019 through 12 April 2019

ER -

Lestari ND, Khalleefah S, Puspitarini S, Widodo , Soewondo A , Rifa'I M. The role of Moringa oliefera -Albumin combination as a traditional medicine to control the development of SDF-1 and TER-119⁺VLA-4⁺ in diabetes mice models. In Mahat NA, Wahab RA, Huyop FZ, Keyon ASA, Attan NB, Chandren S, Gunam IBW, editors, Proceedings of the 2nd International Conference on Biosciences and Medical Engineering, ICBME 2019: Towards Innovative Research and Cross-Disciplinary Collaborations. American Institute of Physics Inc. 2019. 020048. (AIP Conference Proceedings). doi: 10.1063/1.5125552