The incidence of Stevens-Johnson syndrome and toxic epidermal necrolysis in Dr. Saiful Anwar General Hospital Malang, Indonesia from 2012-2017

Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but unpredictable severe hypersensitive reactions with high significant mortality and potentially life-threatening. Indonesia has a large population but study of SJS/TEN in Indonesia is still limited. The purpose of our study was to describe data the patients profile, incidence, mortality, and related diseases based on ICD-10 nomenclature system of all patients with SJS and TEN, retrospectively. Medical records of hospitalized patients with SJS (L51.1), TEN (L51.2) and SJS/TEN overlap (L51.3) from January 1, 2012 to December 31, 2017 in dr.Saiful Anwar General Hospital Malang, Indonesia were reviewed. The study has obtained 75 SJS/TEN (63 SJS; 12 TEN) patients data from 2012 – 2017 with incidence rate was 12.5 cases per years. No SJS/TEN overlap was observed. This study demonstrates that SJS/TEN were more frequent in middle adulthood than other age groups. In SJS, female were more frequent than male. In contrast, male more susceptible to TEN than female. The mortality rate was 9.5% in SJS and 16.7% in TEN or 10.67% in total. Based on ICD-10 classification, eye and adnexa disorder, infection, and endocrine, nutritional, metabolic abnormality were the most frequent complication in SJS and TEN.