The ethanolic extracts therapy of ceremai leaves (Phyllanthus acidus (L.)skeels) on malondialdehyde (MDA) levels and histopathology of hepar of hypercholesterolemic rats

Hypercholesterolemia is high condition when the concentration of cholesterol in blood was increased. Ceremai (Phyllanthus acidus (L.)Skeels) is a plant which used by Indonesian people as aherbal to treat hypercholesterolemia. This study aimed to determine effects of ethanolic extracts therapy of ceremai leaves (Phyllanthus acidus (L.)Skeels) on malondialdehyde (MDA) levels and heparhistopathology of hypercholesterolemic rats (Rattus norvegicus). MDA levels were determined through TBA test (thiobarbituric acid) while hepar histopathology was determined with Hematoxylen-Eosin (HE) staining. The ethanoic extracts therapy of ceremai leaves (Phyllanthus acidus (L.)Skeels) showed could reduce MDA levels of hepar by 37.17% and also 59.92% with doses of 150 mg/kgBW and 300 mg/kgBW, respectivelly. The histopathology of hepar of showed improvement after the therapy. It was concluded, that ceremai leaves could be used to hypercholesterolemia therapy.