TY - GEN
T1 - The effects of garlic (Allium sativum) extracts on the L-thyroxine-induced hyperthyroidism in male rats
AU - Halbuda, Manal Elkamil Aboulgasem
AU - Khotimah, Husnul
AU - Fahanani, Agwin Fahmi
N1 - Publisher Copyright:
© 2021 Author(s).
PY - 2021/5/25
Y1 - 2021/5/25
N2 - Thyroid hormone level variations relate to physiological and clinical anomalies. Many studies showed that garlic has protective effects on various body systems. This study aimed to determine the beneficial effects of garlic extracts against l-thyroxine-induced male rat hyperthyroidism. 25 male rats were randomly grouped into five groups: healthy rats (Control), rats subcutaneously injected with l-thyroxine 0.3 mg/kg BW, and rats given orally doses (100, 150, and 200 mg/kg BW/d) of garlic extracts. Blood samples were taken from the heart at the end of the experiment to identify T3 and T4 using Elisa. The results showed that hyperthyroid rats had a significant increase (p < 0.05) in serum concentrations of T3 and T4 relative to the negative control group, and no significant increase in serum concentrations of T3 and T4 relative to the negative control group at the doses of 100 and 200 mg/kg. However, at the dose of 150 mg/kg BW, the serum concentrations of T3 and T4 decreased. Hyperthyroid rats receiving 100 g/kg garlic extracts were more beneficial in enhancing the behavior of hyperthyroid rats than those in the control group. In conclusion, garlic extracts could affect the level of T3 and T4 in a dose-dependent manner.
AB - Thyroid hormone level variations relate to physiological and clinical anomalies. Many studies showed that garlic has protective effects on various body systems. This study aimed to determine the beneficial effects of garlic extracts against l-thyroxine-induced male rat hyperthyroidism. 25 male rats were randomly grouped into five groups: healthy rats (Control), rats subcutaneously injected with l-thyroxine 0.3 mg/kg BW, and rats given orally doses (100, 150, and 200 mg/kg BW/d) of garlic extracts. Blood samples were taken from the heart at the end of the experiment to identify T3 and T4 using Elisa. The results showed that hyperthyroid rats had a significant increase (p < 0.05) in serum concentrations of T3 and T4 relative to the negative control group, and no significant increase in serum concentrations of T3 and T4 relative to the negative control group at the doses of 100 and 200 mg/kg. However, at the dose of 150 mg/kg BW, the serum concentrations of T3 and T4 decreased. Hyperthyroid rats receiving 100 g/kg garlic extracts were more beneficial in enhancing the behavior of hyperthyroid rats than those in the control group. In conclusion, garlic extracts could affect the level of T3 and T4 in a dose-dependent manner.
UR - https://www.scopus.com/pages/publications/85107310191
U2 - 10.1063/5.0053017
DO - 10.1063/5.0053017
M3 - Conference contribution
AN - SCOPUS:85107310191
T3 - AIP Conference Proceedings
BT - International Conference on Life Sciences and Technology, ICoLiST 2020
A2 - Taufiq, Ahmad
A2 - Susanto, Hendra
A2 - Nur, Hadi
A2 - Aziz, Muhammad
A2 - Suksuwan, Acharee
A2 - Ng, Chen Siang
A2 - Jemon, Khairunadwa Binti
A2 - Amin, Mohamad
A2 - Diantoro, Markus
A2 - Mufti, Nandang
A2 - Malek, Nik Ahmad Nizam Nik
A2 - Wang, I. Ching
A2 - Sunaryono, null
A2 - Zubaidah, Siti
A2 - Aulanni'am, null
A2 - Wibowo, Indra
A2 - Handaya, Adeodatus Yuda
PB - American Institute of Physics Inc.
T2 - 3rd International Conference on Life Sciences and Technology, ICoLiST 2020
Y2 - 29 September 2020
ER -