The effect of frequency of dressing replacement with 0.1% betaine-polyhexanide solution on the formation of collagen and epithelial tissue in albino wistar rats with grade iia burns

Moist wound healing is a method of retaining moisture to increase migration of epithelial cells and synthesis of collagen. One of the liquids that can be used is 0.1% betaine-polyhexanide solution. This study aimed to determine the effect of frequency of dressing replacement with 0.1% betaine-polyhexanide solution on the formation of collagen and epithelial tissue in albino wistar rats with grade IIA burns. The study used the randomized posttest-only control group design to investigate within a period of 13 days 25 male rats, which were divided into 5 groups, each comprising 5 rats. The groups included the control group and the treatment groups with dressing changes every 12 hours, 24 hours, 36 hours, and 48 hours. The variables measured in this study were the epithelium and collagen percentages. One-way ANOVA test revealed a significant difference in the synthesis of collagen with a p-value of 0.002 (p <0.05) but no significant difference in the formation of epithelial tissue with a p-value of 0.561 (p >0.05). The highest score was found in the group with a dressing change every 24 hours. It can be concluded that the treatment of grade IIA burns with 0.1% betaine-polyhexanide solution once every 24 hours can optimize the formation of collagen and epithelial tissue.