The Effect of Flavonoid Isolates from Extract of Phaleria macrocarpa (Scheff.) Boerl on Peritoneal Fluid of Endometriosis Mice

Sutrisno Sutrisno; Ardina Rezky Noeraini; Rizzatul Khumairoh; Maharani Maharani; Tatit Nurseta; Kusworini Handono; Endang Sri Wahyuni; Husnul Khotimah

doi:10.1063/5.0113532

The Effect of Flavonoid Isolates from Extract of Phaleria macrocarpa (Scheff.) Boerl on Peritoneal Fluid of Endometriosis Mice

Sutrisno Sutrisno^*
, Ardina Rezky Noeraini
, Rizzatul Khumairoh
, Maharani Maharani
, Tatit Nurseta
, Kusworini Handono
, Endang Sri Wahyuni
, Husnul Khotimah

^*Corresponding author for this work

Faculty of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Citation (Scopus)

Abstract

Endometriosis is a gynecological disease experienced by women, especially during reproductive age. Endometriosis treatment is still less effective considering the side effects and high recurrence rate. Phaleria macrocarpa (PM) is a plant that has bioactivity, such as antioxidants and angiogenesis. The purpose of this study is to analyze the effect of flavonoid isolates from Phaleria macrocarpa fruit extract on Superoxide Dismustase (SOD) and Vascular Endothelial Growth Factor (VEGF) levels in endometriosis mice. Thirty female mice (Mus musculus) were divided into 6 groups, including the control group (without any treatment), Endometriosis/EMT (without PM), and EMT with flavonoid isolation from PM extract at a dose of 3.75; 7.5; 11.2; 15 mg/day. The sample used in this study was peritoneal fluid. Examination of SOD and VEGF levels was carried out using the ELISA method. The results show an increase in SOD levels and a decrease in VEGF levels in the peritoneal fluid of endometriosis mice compared to the control group (without any treatment). Flavonoid isolation from P.macrocarpa can increase SOD levels and reduce VEGF levels in Endometriosis mice. Thus, P. macrocarpa can be used as an alternative to suppress the growth of endometriosis.

Original language	English
Title of host publication	4th International Conference on Life Science and Technology, ICoLiST 2023
Editors	Ahmad Taufiq, Hendra Susanto, I. Ching Wang, Hadi Nur, Muhammad Aziz, Chuang-Rung Chang, Gereon Elbers, Sri Rahayu Lestari, Markus Diantoro, Nandang Mufti, Chen Siang Ng, Nik Ahmad Nizam Nik Malek, Sunaryono, Yu-Hsin Chiu, Siti Zubaidah, Aulanni'am, Indra Wibowo, Adeodatus Yuda Handaya
Publisher	American Institute of Physics Inc.
ISBN (Electronic)	9780735443136
DOIs	https://doi.org/10.1063/5.0113532
Publication status	Published - 24 Jan 2023
Event	4th International Conference on Life Science and Technology, ICoLiST 2023 - Virtual, Online, Indonesia Duration: 31 Aug 2021 → …

Publication series

Name	AIP Conference Proceedings
Volume	2634
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	4th International Conference on Life Science and Technology, ICoLiST 2023
Country/Territory	Indonesia
City	Virtual, Online
Period	31/08/21 → …

Access to Document

10.1063/5.0113532

Cite this

Sutrisno, S., Noeraini, A. R., Khumairoh, R., Maharani, M., Nurseta, T., Handono, K., Wahyuni, E. S., & Khotimah, H. (2023). The Effect of Flavonoid Isolates from Extract of Phaleria macrocarpa (Scheff.) Boerl on Peritoneal Fluid of Endometriosis Mice. In A. Taufiq, H. Susanto, I. C. Wang, H. Nur, M. Aziz, C.-R. Chang, G. Elbers, S. R. Lestari, M. Diantoro, N. Mufti, C. S. Ng, N. A. N. N. Malek, Sunaryono, Y.-H. Chiu, S. Zubaidah, Aulanni'am, I. Wibowo, & A. Y. Handaya (Eds.), 4th International Conference on Life Science and Technology, ICoLiST 2023 Article 020072 (AIP Conference Proceedings; Vol. 2634). American Institute of Physics Inc.. https://doi.org/10.1063/5.0113532

Sutrisno, Sutrisno ; Noeraini, Ardina Rezky ; Khumairoh, Rizzatul et al. / The Effect of Flavonoid Isolates from Extract of Phaleria macrocarpa (Scheff.) Boerl on Peritoneal Fluid of Endometriosis Mice. 4th International Conference on Life Science and Technology, ICoLiST 2023. editor / Ahmad Taufiq ; Hendra Susanto ; I. Ching Wang ; Hadi Nur ; Muhammad Aziz ; Chuang-Rung Chang ; Gereon Elbers ; Sri Rahayu Lestari ; Markus Diantoro ; Nandang Mufti ; Chen Siang Ng ; Nik Ahmad Nizam Nik Malek ; Sunaryono ; Yu-Hsin Chiu ; Siti Zubaidah ; Aulanni'am ; Indra Wibowo ; Adeodatus Yuda Handaya. American Institute of Physics Inc., 2023. (AIP Conference Proceedings).

@inproceedings{9e839bfc5ec342938a555ec8a8840661,

title = "The Effect of Flavonoid Isolates from Extract of Phaleria macrocarpa (Scheff.) Boerl on Peritoneal Fluid of Endometriosis Mice",

abstract = "Endometriosis is a gynecological disease experienced by women, especially during reproductive age. Endometriosis treatment is still less effective considering the side effects and high recurrence rate. Phaleria macrocarpa (PM) is a plant that has bioactivity, such as antioxidants and angiogenesis. The purpose of this study is to analyze the effect of flavonoid isolates from Phaleria macrocarpa fruit extract on Superoxide Dismustase (SOD) and Vascular Endothelial Growth Factor (VEGF) levels in endometriosis mice. Thirty female mice (Mus musculus) were divided into 6 groups, including the control group (without any treatment), Endometriosis/EMT (without PM), and EMT with flavonoid isolation from PM extract at a dose of 3.75; 7.5; 11.2; 15 mg/day. The sample used in this study was peritoneal fluid. Examination of SOD and VEGF levels was carried out using the ELISA method. The results show an increase in SOD levels and a decrease in VEGF levels in the peritoneal fluid of endometriosis mice compared to the control group (without any treatment). Flavonoid isolation from P.macrocarpa can increase SOD levels and reduce VEGF levels in Endometriosis mice. Thus, P. macrocarpa can be used as an alternative to suppress the growth of endometriosis.",

author = "Sutrisno Sutrisno and Noeraini, \{Ardina Rezky\} and Rizzatul Khumairoh and Maharani Maharani and Tatit Nurseta and Kusworini Handono and Wahyuni, \{Endang Sri\} and Husnul Khotimah",

note = "Publisher Copyright: {\textcopyright} 2023 American Institute of Physics Inc.. All rights reserved.; 4th International Conference on Life Science and Technology, ICoLiST 2023 ; Conference date: 31-08-2021",

year = "2023",

month = jan,

day = "24",

doi = "10.1063/5.0113532",

language = "English",

series = "AIP Conference Proceedings",

publisher = "American Institute of Physics Inc.",

editor = "Ahmad Taufiq and Hendra Susanto and Wang, \{I. Ching\} and Hadi Nur and Muhammad Aziz and Chuang-Rung Chang and Gereon Elbers and Lestari, \{Sri Rahayu\} and Markus Diantoro and Nandang Mufti and Ng, \{Chen Siang\} and Malek, \{Nik Ahmad Nizam Nik\} and Sunaryono and Yu-Hsin Chiu and Siti Zubaidah and Aulanni'am and Indra Wibowo and Handaya, \{Adeodatus Yuda\}",

booktitle = "4th International Conference on Life Science and Technology, ICoLiST 2023",

}

Sutrisno, S, Noeraini, AR, Khumairoh, R, Maharani, M, Nurseta, T , Handono, K, Wahyuni, ES & Khotimah, H 2023, The Effect of Flavonoid Isolates from Extract of Phaleria macrocarpa (Scheff.) Boerl on Peritoneal Fluid of Endometriosis Mice. in A Taufiq, H Susanto, IC Wang, H Nur, M Aziz, C-R Chang, G Elbers, SR Lestari, M Diantoro, N Mufti, CS Ng, NANN Malek, Sunaryono, Y-H Chiu, S Zubaidah, Aulanni'am, I Wibowo & AY Handaya (eds), 4th International Conference on Life Science and Technology, ICoLiST 2023., 020072, AIP Conference Proceedings, vol. 2634, American Institute of Physics Inc., 4th International Conference on Life Science and Technology, ICoLiST 2023, Virtual, Online, Indonesia, 31/08/21. https://doi.org/10.1063/5.0113532

The Effect of Flavonoid Isolates from Extract of Phaleria macrocarpa (Scheff.) Boerl on Peritoneal Fluid of Endometriosis Mice. / Sutrisno, Sutrisno; Noeraini, Ardina Rezky; Khumairoh, Rizzatul et al.
4th International Conference on Life Science and Technology, ICoLiST 2023. ed. / Ahmad Taufiq; Hendra Susanto; I. Ching Wang; Hadi Nur; Muhammad Aziz; Chuang-Rung Chang; Gereon Elbers; Sri Rahayu Lestari; Markus Diantoro; Nandang Mufti; Chen Siang Ng; Nik Ahmad Nizam Nik Malek; Sunaryono; Yu-Hsin Chiu; Siti Zubaidah; Aulanni'am; Indra Wibowo; Adeodatus Yuda Handaya. American Institute of Physics Inc., 2023. 020072 (AIP Conference Proceedings; Vol. 2634).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - The Effect of Flavonoid Isolates from Extract of Phaleria macrocarpa (Scheff.) Boerl on Peritoneal Fluid of Endometriosis Mice

AU - Sutrisno, Sutrisno

AU - Noeraini, Ardina Rezky

AU - Khumairoh, Rizzatul

AU - Maharani, Maharani

AU - Nurseta, Tatit

AU - Handono, Kusworini

AU - Wahyuni, Endang Sri

AU - Khotimah, Husnul

PY - 2023/1/24

Y1 - 2023/1/24

N2 - Endometriosis is a gynecological disease experienced by women, especially during reproductive age. Endometriosis treatment is still less effective considering the side effects and high recurrence rate. Phaleria macrocarpa (PM) is a plant that has bioactivity, such as antioxidants and angiogenesis. The purpose of this study is to analyze the effect of flavonoid isolates from Phaleria macrocarpa fruit extract on Superoxide Dismustase (SOD) and Vascular Endothelial Growth Factor (VEGF) levels in endometriosis mice. Thirty female mice (Mus musculus) were divided into 6 groups, including the control group (without any treatment), Endometriosis/EMT (without PM), and EMT with flavonoid isolation from PM extract at a dose of 3.75; 7.5; 11.2; 15 mg/day. The sample used in this study was peritoneal fluid. Examination of SOD and VEGF levels was carried out using the ELISA method. The results show an increase in SOD levels and a decrease in VEGF levels in the peritoneal fluid of endometriosis mice compared to the control group (without any treatment). Flavonoid isolation from P.macrocarpa can increase SOD levels and reduce VEGF levels in Endometriosis mice. Thus, P. macrocarpa can be used as an alternative to suppress the growth of endometriosis.

AB - Endometriosis is a gynecological disease experienced by women, especially during reproductive age. Endometriosis treatment is still less effective considering the side effects and high recurrence rate. Phaleria macrocarpa (PM) is a plant that has bioactivity, such as antioxidants and angiogenesis. The purpose of this study is to analyze the effect of flavonoid isolates from Phaleria macrocarpa fruit extract on Superoxide Dismustase (SOD) and Vascular Endothelial Growth Factor (VEGF) levels in endometriosis mice. Thirty female mice (Mus musculus) were divided into 6 groups, including the control group (without any treatment), Endometriosis/EMT (without PM), and EMT with flavonoid isolation from PM extract at a dose of 3.75; 7.5; 11.2; 15 mg/day. The sample used in this study was peritoneal fluid. Examination of SOD and VEGF levels was carried out using the ELISA method. The results show an increase in SOD levels and a decrease in VEGF levels in the peritoneal fluid of endometriosis mice compared to the control group (without any treatment). Flavonoid isolation from P.macrocarpa can increase SOD levels and reduce VEGF levels in Endometriosis mice. Thus, P. macrocarpa can be used as an alternative to suppress the growth of endometriosis.

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U2 - 10.1063/5.0113532

DO - 10.1063/5.0113532

M3 - Conference contribution

AN - SCOPUS:85147301826

T3 - AIP Conference Proceedings

BT - 4th International Conference on Life Science and Technology, ICoLiST 2023

A2 - Taufiq, Ahmad

A2 - Susanto, Hendra

A2 - Wang, I. Ching

A2 - Nur, Hadi

A2 - Aziz, Muhammad

A2 - Chang, Chuang-Rung

A2 - Elbers, Gereon

A2 - Lestari, Sri Rahayu

A2 - Diantoro, Markus

A2 - Mufti, Nandang

A2 - Ng, Chen Siang

A2 - Malek, Nik Ahmad Nizam Nik

A2 - Sunaryono, null

A2 - Chiu, Yu-Hsin

A2 - Zubaidah, Siti

A2 - Aulanni'am, null

A2 - Wibowo, Indra

A2 - Handaya, Adeodatus Yuda

PB - American Institute of Physics Inc.

T2 - 4th International Conference on Life Science and Technology, ICoLiST 2023

Y2 - 31 August 2021

ER -

Sutrisno S, Noeraini AR, Khumairoh R, Maharani M, Nurseta T , Handono K et al. The Effect of Flavonoid Isolates from Extract of Phaleria macrocarpa (Scheff.) Boerl on Peritoneal Fluid of Endometriosis Mice. In Taufiq A, Susanto H, Wang IC, Nur H, Aziz M, Chang CR, Elbers G, Lestari SR, Diantoro M, Mufti N, Ng CS, Malek NANN, Sunaryono, Chiu YH, Zubaidah S, Aulanni'am, Wibowo I, Handaya AY, editors, 4th International Conference on Life Science and Technology, ICoLiST 2023. American Institute of Physics Inc. 2023. 020072. (AIP Conference Proceedings). doi: 10.1063/5.0113532

The Effect of Flavonoid Isolates from Extract of Phaleria macrocarpa (Scheff.) Boerl on Peritoneal Fluid of Endometriosis Mice

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