The effect of cypermethrin on Jambal roti to AST and ALT levels the wistar rat (Rattus norvegicus)

Cypermethrin are used to control pests, diseases and weeds on agricultural activities. Yet, producer of Jambal Roti used it to prevent decomposition, thus lengthen the product shelf life and reduced the loss. This study aimed to determine the effect of cypermethrin to AST (Aspartate Aminotransferase) and ALT (Alanine Aminotransferase) levels of Wistar Rats (Rattus norvegicus). Wistar Rat treated of cypermethrin exposure with doses 0.00 mg/kg (K-), 0.05 mg/kg, 0.60 mg/kg, 1.10 mg/kg, 1.60 mg/kg, 2.15 mg/kg and fish meat containing cypermethrin 1.73 mg/kg (positive control: K+). AST and ALT level on blood of rats determined by Enzymatic photometric method. The results showed that cypermethrin increase the level of AST and ALT of Wistar Rats. The highest levels of AST and ALT is 117±0.58 IU/L and 25±0.58 IU/L, which obtained at doses of 2.15 mg/kg cypermethrin.