The Effect of α-Mangostin on TLR-4 and PGE2 in the Dentin-Pulp Complex Exposed to HEMA

Febriastuti Cahyani; Widya Saraswati; Eric Priyo Prasetyo; Meircurius Dwi Condro Surboyo; Wibi Riawan; Karina Erda Saninggar; Ninuk Hariyani; Anisa Kusumawardani; Adioro Soetojo; Soetjipto

The Effect of α-Mangostin on TLR-4 and PGE2 in the Dentin-Pulp Complex Exposed to HEMA

Febriastuti Cahyani
, Widya Saraswati
, Eric Priyo Prasetyo
, Meircurius Dwi Condro Surboyo
, Wibi Riawan
, Karina Erda Saninggar
, Ninuk Hariyani
, Anisa Kusumawardani
, Adioro Soetojo^*
, Soetjipto

^*Corresponding author for this work

Faculty of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Mangosteen is abundant in Indonesia. Most mangosteen pericarp contains Alpha (α) mangostin, which has numerous biological benefits, especially antioxidant, antibacterial and antiinflammatory properties. The purpose of this study is to analyse the effect of α-mangostin on tolllike receptor 4 (TLR-4) and prostaglandin E2 (PGE2) in vivo. An in vivo study was conducted using 42 male Wistar rats (Rattus norvegicus) in randomised post-test control groups. The rats were divided into a control group applied 2-hydroxyethyl methacrylate (HEMA) and a treatment group applied HEMA and 12,5µg/ml of α-mangostin. The inflammatory factors on the dentin-pulp complex of the rat’s model were examined. TLR-4 was detected via immunohistochemistry and PGE2 was assayed via ELISA after 24, 48 and 72 hours. In vivo results showed a decrease in TLR-4 and PGE2 after α-mangostin treatment. Recent studies have shown that α-mangostin can significantly decrease TLR-4 and PGE2 on a dentin-pulp complex after exposure to HEMA.

Original language	English
Pages (from-to)	21-26
Number of pages	6
Journal	Journal of International Dental and Medical Research
Volume	15
Issue number	1
Publication status	Published - 2022

Keywords

Dentin-pulp complex
Hema
Human&health
Pge2
Tlr-4
Α-mangostin

Cite this

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title = "The Effect of α-Mangostin on TLR-4 and PGE2 in the Dentin-Pulp Complex Exposed to HEMA",

abstract = "Mangosteen is abundant in Indonesia. Most mangosteen pericarp contains Alpha (α) mangostin, which has numerous biological benefits, especially antioxidant, antibacterial and antiinflammatory properties. The purpose of this study is to analyse the effect of α-mangostin on tolllike receptor 4 (TLR-4) and prostaglandin E2 (PGE2) in vivo. An in vivo study was conducted using 42 male Wistar rats (Rattus norvegicus) in randomised post-test control groups. The rats were divided into a control group applied 2-hydroxyethyl methacrylate (HEMA) and a treatment group applied HEMA and 12,5µg/ml of α-mangostin. The inflammatory factors on the dentin-pulp complex of the rat{\textquoteright}s model were examined. TLR-4 was detected via immunohistochemistry and PGE2 was assayed via ELISA after 24, 48 and 72 hours. In vivo results showed a decrease in TLR-4 and PGE2 after α-mangostin treatment. Recent studies have shown that α-mangostin can significantly decrease TLR-4 and PGE2 on a dentin-pulp complex after exposure to HEMA.",

keywords = "Dentin-pulp complex, Hema, Human\&health, Pge2, Tlr-4, Α-mangostin",

author = "Febriastuti Cahyani and Widya Saraswati and Prasetyo, \{Eric Priyo\} and Surboyo, \{Meircurius Dwi Condro\} and Wibi Riawan and Saninggar, \{Karina Erda\} and Ninuk Hariyani and Anisa Kusumawardani and Adioro Soetojo and Soetjipto",

year = "2022",

language = "English",

volume = "15",

pages = "21--26",

journal = "Journal of International Dental and Medical Research",

issn = "1309-100X",

publisher = "University of Dicle",

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T1 - The Effect of α-Mangostin on TLR-4 and PGE2 in the Dentin-Pulp Complex Exposed to HEMA

AU - Cahyani, Febriastuti

AU - Saraswati, Widya

AU - Prasetyo, Eric Priyo

AU - Surboyo, Meircurius Dwi Condro

AU - Riawan, Wibi

AU - Saninggar, Karina Erda

AU - Hariyani, Ninuk

AU - Kusumawardani, Anisa

AU - Soetojo, Adioro

AU - Soetjipto,

PY - 2022

Y1 - 2022

N2 - Mangosteen is abundant in Indonesia. Most mangosteen pericarp contains Alpha (α) mangostin, which has numerous biological benefits, especially antioxidant, antibacterial and antiinflammatory properties. The purpose of this study is to analyse the effect of α-mangostin on tolllike receptor 4 (TLR-4) and prostaglandin E2 (PGE2) in vivo. An in vivo study was conducted using 42 male Wistar rats (Rattus norvegicus) in randomised post-test control groups. The rats were divided into a control group applied 2-hydroxyethyl methacrylate (HEMA) and a treatment group applied HEMA and 12,5µg/ml of α-mangostin. The inflammatory factors on the dentin-pulp complex of the rat’s model were examined. TLR-4 was detected via immunohistochemistry and PGE2 was assayed via ELISA after 24, 48 and 72 hours. In vivo results showed a decrease in TLR-4 and PGE2 after α-mangostin treatment. Recent studies have shown that α-mangostin can significantly decrease TLR-4 and PGE2 on a dentin-pulp complex after exposure to HEMA.

AB - Mangosteen is abundant in Indonesia. Most mangosteen pericarp contains Alpha (α) mangostin, which has numerous biological benefits, especially antioxidant, antibacterial and antiinflammatory properties. The purpose of this study is to analyse the effect of α-mangostin on tolllike receptor 4 (TLR-4) and prostaglandin E2 (PGE2) in vivo. An in vivo study was conducted using 42 male Wistar rats (Rattus norvegicus) in randomised post-test control groups. The rats were divided into a control group applied 2-hydroxyethyl methacrylate (HEMA) and a treatment group applied HEMA and 12,5µg/ml of α-mangostin. The inflammatory factors on the dentin-pulp complex of the rat’s model were examined. TLR-4 was detected via immunohistochemistry and PGE2 was assayed via ELISA after 24, 48 and 72 hours. In vivo results showed a decrease in TLR-4 and PGE2 after α-mangostin treatment. Recent studies have shown that α-mangostin can significantly decrease TLR-4 and PGE2 on a dentin-pulp complex after exposure to HEMA.

KW - Dentin-pulp complex

KW - Hema

KW - Human&health

KW - Pge2

KW - Tlr-4

KW - Α-mangostin

UR - https://www.scopus.com/pages/publications/85129438894

M3 - Article

AN - SCOPUS:85129438894

SN - 1309-100X

VL - 15

SP - 21

EP - 26

JO - Journal of International Dental and Medical Research

JF - Journal of International Dental and Medical Research

IS - 1

ER -

The Effect of α-Mangostin on TLR-4 and PGE2 in the Dentin-Pulp Complex Exposed to HEMA

Abstract

Keywords

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