The Early Detection of Diabetes Mellitus in Younger Female Obese: A Pilot Project for GAD65 Kit in Students Community

Hendra Susanto; Lutfiyah Magfiroh Azis; Aulanni'am Aulanni'am; Dyah Kinasih Wuragil; Wira Eka Putra; Fatma Yuni Reformawati; Moch Sholeh; Sa'diyatul Rizqie Amaliyah Firdaus

doi:10.1063/5.0129428

The Early Detection of Diabetes Mellitus in Younger Female Obese: A Pilot Project for GAD65 Kit in Students Community

Hendra Susanto^*
, Lutfiyah Magfiroh Azis
, Aulanni'am Aulanni'am
, Dyah Kinasih Wuragil
, Wira Eka Putra
, Fatma Yuni Reformawati
, Moch Sholeh
, Sa'diyatul Rizqie Amaliyah Firdaus

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Obesity is a fundamental risk factor with significant correlation to Diabetes Mellitus (DM) development. The incidence of visceral obesity is observed predominantly in females than males. As a consequence, it can be a potential trigger to develop diabetes. Notably, the late diagnostic of diabetes at an individual younger age provides a significant challenge to provide the sensitive and cheaper medical tool for early detection of DM. This pilot study was designed to explore the performance of the GAD65 Rapid Test Kit in early detection of DM, especially in the younger female with obese criteria. Twenty-six individuals were chosen as the sample and had filled the informed consent. The mean of fasting blood glucose was 90 mg/dL, BMI 29.2 kg/m², and body fat 44.1%. The serum samples were then tested by Reverse-Flow Immunochromatography kit for GAD65 protein. Almost 81% of the samples are positive for GAD65, even with a standard fasting glucose profile. The presence of GAD65 protein in these subjects can predict the autoimmunity probability and beta-cell dysfunction-related diabetes progression. Therefore, the application of this rapid test kit can be proposed as an alternative best way to prevent the significant increase of diabetes, in particular for the younger population.

Original language	English
Title of host publication	4th International Conference on Life Science and Technology, ICoLiST 2023
Editors	Ahmad Taufiq, Hendra Susanto, I. Ching Wang, Hadi Nur, Muhammad Aziz, Chuang-Rung Chang, Gereon Elbers, Sri Rahayu Lestari, Markus Diantoro, Nandang Mufti, Chen Siang Ng, Nik Ahmad Nizam Nik Malek, Sunaryono, Yu-Hsin Chiu, Siti Zubaidah, Aulanni'am, Indra Wibowo, Adeodatus Yuda Handaya
Publisher	American Institute of Physics Inc.
ISBN (Electronic)	9780735443136
DOIs	https://doi.org/10.1063/5.0129428
Publication status	Published - 24 Jan 2023
Event	4th International Conference on Life Science and Technology, ICoLiST 2023 - Virtual, Online, Indonesia Duration: 31 Aug 2021 → …

Publication series

Name	AIP Conference Proceedings
Volume	2634
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	4th International Conference on Life Science and Technology, ICoLiST 2023
Country/Territory	Indonesia
City	Virtual, Online
Period	31/08/21 → …

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1063/5.0129428

Cite this

Susanto, H., Azis, L. M., Aulanni'am, A., Wuragil, D. K., Putra, W. E., Reformawati, F. Y., Sholeh, M., & Firdaus, S. R. A. (2023). The Early Detection of Diabetes Mellitus in Younger Female Obese: A Pilot Project for GAD65 Kit in Students Community. In A. Taufiq, H. Susanto, I. C. Wang, H. Nur, M. Aziz, C.-R. Chang, G. Elbers, S. R. Lestari, M. Diantoro, N. Mufti, C. S. Ng, N. A. N. N. Malek, Sunaryono, Y.-H. Chiu, S. Zubaidah, Aulanni'am, I. Wibowo, & A. Y. Handaya (Eds.), 4th International Conference on Life Science and Technology, ICoLiST 2023 Article 020018 (AIP Conference Proceedings; Vol. 2634). American Institute of Physics Inc.. https://doi.org/10.1063/5.0129428

Susanto, Hendra ; Azis, Lutfiyah Magfiroh ; Aulanni'am, Aulanni'am et al. / The Early Detection of Diabetes Mellitus in Younger Female Obese : A Pilot Project for GAD65 Kit in Students Community. 4th International Conference on Life Science and Technology, ICoLiST 2023. editor / Ahmad Taufiq ; Hendra Susanto ; I. Ching Wang ; Hadi Nur ; Muhammad Aziz ; Chuang-Rung Chang ; Gereon Elbers ; Sri Rahayu Lestari ; Markus Diantoro ; Nandang Mufti ; Chen Siang Ng ; Nik Ahmad Nizam Nik Malek ; Sunaryono ; Yu-Hsin Chiu ; Siti Zubaidah ; Aulanni'am ; Indra Wibowo ; Adeodatus Yuda Handaya. American Institute of Physics Inc., 2023. (AIP Conference Proceedings).

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title = "The Early Detection of Diabetes Mellitus in Younger Female Obese: A Pilot Project for GAD65 Kit in Students Community",

abstract = "Obesity is a fundamental risk factor with significant correlation to Diabetes Mellitus (DM) development. The incidence of visceral obesity is observed predominantly in females than males. As a consequence, it can be a potential trigger to develop diabetes. Notably, the late diagnostic of diabetes at an individual younger age provides a significant challenge to provide the sensitive and cheaper medical tool for early detection of DM. This pilot study was designed to explore the performance of the GAD65 Rapid Test Kit in early detection of DM, especially in the younger female with obese criteria. Twenty-six individuals were chosen as the sample and had filled the informed consent. The mean of fasting blood glucose was 90 mg/dL, BMI 29.2 kg/m2, and body fat 44.1\%. The serum samples were then tested by Reverse-Flow Immunochromatography kit for GAD65 protein. Almost 81\% of the samples are positive for GAD65, even with a standard fasting glucose profile. The presence of GAD65 protein in these subjects can predict the autoimmunity probability and beta-cell dysfunction-related diabetes progression. Therefore, the application of this rapid test kit can be proposed as an alternative best way to prevent the significant increase of diabetes, in particular for the younger population.",

author = "Hendra Susanto and Azis, \{Lutfiyah Magfiroh\} and Aulanni'am Aulanni'am and Wuragil, \{Dyah Kinasih\} and Putra, \{Wira Eka\} and Reformawati, \{Fatma Yuni\} and Moch Sholeh and Firdaus, \{Sa'diyatul Rizqie Amaliyah\}",

note = "Publisher Copyright: {\textcopyright} 2023 American Institute of Physics Inc.. All rights reserved.; 4th International Conference on Life Science and Technology, ICoLiST 2023 ; Conference date: 31-08-2021",

year = "2023",

month = jan,

day = "24",

doi = "10.1063/5.0129428",

language = "English",

series = "AIP Conference Proceedings",

publisher = "American Institute of Physics Inc.",

editor = "Ahmad Taufiq and Hendra Susanto and Wang, \{I. Ching\} and Hadi Nur and Muhammad Aziz and Chuang-Rung Chang and Gereon Elbers and Lestari, \{Sri Rahayu\} and Markus Diantoro and Nandang Mufti and Ng, \{Chen Siang\} and Malek, \{Nik Ahmad Nizam Nik\} and Sunaryono and Yu-Hsin Chiu and Siti Zubaidah and Aulanni'am and Indra Wibowo and Handaya, \{Adeodatus Yuda\}",

booktitle = "4th International Conference on Life Science and Technology, ICoLiST 2023",

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Susanto, H, Azis, LM, Aulanni'am, A , Wuragil, DK, Putra, WE, Reformawati, FY, Sholeh, M & Firdaus, SRA 2023, The Early Detection of Diabetes Mellitus in Younger Female Obese: A Pilot Project for GAD65 Kit in Students Community. in A Taufiq, H Susanto, IC Wang, H Nur, M Aziz, C-R Chang, G Elbers, SR Lestari, M Diantoro, N Mufti, CS Ng, NANN Malek, Sunaryono, Y-H Chiu, S Zubaidah, Aulanni'am, I Wibowo & AY Handaya (eds), 4th International Conference on Life Science and Technology, ICoLiST 2023., 020018, AIP Conference Proceedings, vol. 2634, American Institute of Physics Inc., 4th International Conference on Life Science and Technology, ICoLiST 2023, Virtual, Online, Indonesia, 31/08/21. https://doi.org/10.1063/5.0129428

The Early Detection of Diabetes Mellitus in Younger Female Obese: A Pilot Project for GAD65 Kit in Students Community. / Susanto, Hendra; Azis, Lutfiyah Magfiroh; Aulanni'am, Aulanni'am et al.
4th International Conference on Life Science and Technology, ICoLiST 2023. ed. / Ahmad Taufiq; Hendra Susanto; I. Ching Wang; Hadi Nur; Muhammad Aziz; Chuang-Rung Chang; Gereon Elbers; Sri Rahayu Lestari; Markus Diantoro; Nandang Mufti; Chen Siang Ng; Nik Ahmad Nizam Nik Malek; Sunaryono; Yu-Hsin Chiu; Siti Zubaidah; Aulanni'am; Indra Wibowo; Adeodatus Yuda Handaya. American Institute of Physics Inc., 2023. 020018 (AIP Conference Proceedings; Vol. 2634).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T2 - 4th International Conference on Life Science and Technology, ICoLiST 2023

AU - Susanto, Hendra

AU - Azis, Lutfiyah Magfiroh

AU - Aulanni'am, Aulanni'am

AU - Wuragil, Dyah Kinasih

AU - Putra, Wira Eka

AU - Reformawati, Fatma Yuni

AU - Sholeh, Moch

AU - Firdaus, Sa'diyatul Rizqie Amaliyah

PY - 2023/1/24

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N2 - Obesity is a fundamental risk factor with significant correlation to Diabetes Mellitus (DM) development. The incidence of visceral obesity is observed predominantly in females than males. As a consequence, it can be a potential trigger to develop diabetes. Notably, the late diagnostic of diabetes at an individual younger age provides a significant challenge to provide the sensitive and cheaper medical tool for early detection of DM. This pilot study was designed to explore the performance of the GAD65 Rapid Test Kit in early detection of DM, especially in the younger female with obese criteria. Twenty-six individuals were chosen as the sample and had filled the informed consent. The mean of fasting blood glucose was 90 mg/dL, BMI 29.2 kg/m2, and body fat 44.1%. The serum samples were then tested by Reverse-Flow Immunochromatography kit for GAD65 protein. Almost 81% of the samples are positive for GAD65, even with a standard fasting glucose profile. The presence of GAD65 protein in these subjects can predict the autoimmunity probability and beta-cell dysfunction-related diabetes progression. Therefore, the application of this rapid test kit can be proposed as an alternative best way to prevent the significant increase of diabetes, in particular for the younger population.

AB - Obesity is a fundamental risk factor with significant correlation to Diabetes Mellitus (DM) development. The incidence of visceral obesity is observed predominantly in females than males. As a consequence, it can be a potential trigger to develop diabetes. Notably, the late diagnostic of diabetes at an individual younger age provides a significant challenge to provide the sensitive and cheaper medical tool for early detection of DM. This pilot study was designed to explore the performance of the GAD65 Rapid Test Kit in early detection of DM, especially in the younger female with obese criteria. Twenty-six individuals were chosen as the sample and had filled the informed consent. The mean of fasting blood glucose was 90 mg/dL, BMI 29.2 kg/m2, and body fat 44.1%. The serum samples were then tested by Reverse-Flow Immunochromatography kit for GAD65 protein. Almost 81% of the samples are positive for GAD65, even with a standard fasting glucose profile. The presence of GAD65 protein in these subjects can predict the autoimmunity probability and beta-cell dysfunction-related diabetes progression. Therefore, the application of this rapid test kit can be proposed as an alternative best way to prevent the significant increase of diabetes, in particular for the younger population.

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DO - 10.1063/5.0129428

M3 - Conference contribution

AN - SCOPUS:85147315297

T3 - AIP Conference Proceedings

BT - 4th International Conference on Life Science and Technology, ICoLiST 2023

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A2 - Susanto, Hendra

A2 - Wang, I. Ching

A2 - Nur, Hadi

A2 - Aziz, Muhammad

A2 - Chang, Chuang-Rung

A2 - Elbers, Gereon

A2 - Lestari, Sri Rahayu

A2 - Diantoro, Markus

A2 - Mufti, Nandang

A2 - Ng, Chen Siang

A2 - Malek, Nik Ahmad Nizam Nik

A2 - Sunaryono, null

A2 - Chiu, Yu-Hsin

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PB - American Institute of Physics Inc.

Y2 - 31 August 2021

ER -

Susanto H, Azis LM, Aulanni'am A , Wuragil DK, Putra WE, Reformawati FY et al. The Early Detection of Diabetes Mellitus in Younger Female Obese: A Pilot Project for GAD65 Kit in Students Community. In Taufiq A, Susanto H, Wang IC, Nur H, Aziz M, Chang CR, Elbers G, Lestari SR, Diantoro M, Mufti N, Ng CS, Malek NANN, Sunaryono, Chiu YH, Zubaidah S, Aulanni'am, Wibowo I, Handaya AY, editors, 4th International Conference on Life Science and Technology, ICoLiST 2023. American Institute of Physics Inc. 2023. 020018. (AIP Conference Proceedings). doi: 10.1063/5.0129428

The Early Detection of Diabetes Mellitus in Younger Female Obese: A Pilot Project for GAD65 Kit in Students Community

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