The behavioral effect of anthocyanin from purple sweet potatoes on prenatally stressed offspring mice

Prenatal stress is major risk factor for long-lasting psychopathological development on offspring including depression. The objectives of this study were to investigate the effect of anthocyanin from purple sweet potatoes on behavioral performances of prenatally stressed offspring as well as the prediction of mechanism using in silico analysis. The pregnant mice were physically restrained during the half late pregnancy for 2 hours each day. The adolescent offspring were then treat using total anthocyanin extracts from purple sweet potatoes. The open field test and tail suspension test were performed for behavioral analysis. The results were demonstrated that the administration of anthocyanin significantly increases the immobility time. Conversely, track visualization was shown more explorative movement on mice. Virtual molecular interaction was demonstrated that anthocyanins of delphinidin and malvidin have similar interaction with GABA and baclofen as GABAB receptor agonist. Recent results are gaining a necessary of further exploration with more complex behavioral test procedures and the determination of anthocyanin on GABAergic transmission in animal model of depression.