The activity of Rhizomuchor miehei lipase as a biocatalyst in enzymatic acylation of cyclic alcohol

Elvina Dhiaul Iftitah; Arie Srihardyastuti; Mokhamat Ariefin

doi:10.1063/1.4978190

The activity of Rhizomuchor miehei lipase as a biocatalyst in enzymatic acylation of cyclic alcohol

Elvina Dhiaul Iftitah^*
, Arie Srihardyastuti
, Mokhamat Ariefin

^*Corresponding author for this work

Faculty of Mathematics and Natural Sciences

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Citation (Scopus)

Abstract

We report the activity of Rhizomuchor miehei lipase (RML) as a biocatalyst, in particular the investigations concerning the effort of substrate-structure reactivity on the enzymatic acylation. The acylation was studied using acetic anhydride as an acyl donor and performed in n-hexane as a solvent. The selectivity of the enzymatic acylation was revealed by Gas Chromatography-Mass Spectra. We observed that, RML has shown different behavior when catalyzing the acylation of isopulegol and mixture of isopulegol and citronellal (ratio 1:1). The chemoselectivity for the O-acylation was improved when the acyl acceptor included mixture of isopulegol and citronellal.

Original language	English
Title of host publication	International Conference on Chemistry, Chemical Process and Engineering, IC3PE 2017
Editors	Is Fatimah, Gani Purwiandono
Publisher	American Institute of Physics Inc.
ISBN (Electronic)	9780735414914
DOIs	https://doi.org/10.1063/1.4978190
Publication status	Published - 17 Mar 2017
Event	International Conference on Chemistry, Chemical Process and Engineering, IC3PE 2017 - Yogyakarta, Indonesia Duration: 15 Nov 2016 → 16 Nov 2016

Publication series

Name	AIP Conference Proceedings
Volume	1823
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	International Conference on Chemistry, Chemical Process and Engineering, IC3PE 2017
Country/Territory	Indonesia
City	Yogyakarta
Period	15/11/16 → 16/11/16

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10.1063/1.4978190

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Iftitah, E. D., Srihardyastuti, A., & Ariefin, M. (2017). The activity of Rhizomuchor miehei lipase as a biocatalyst in enzymatic acylation of cyclic alcohol. In I. Fatimah, & G. Purwiandono (Eds.), International Conference on Chemistry, Chemical Process and Engineering, IC3PE 2017 Article 020117 (AIP Conference Proceedings; Vol. 1823). American Institute of Physics Inc.. https://doi.org/10.1063/1.4978190

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title = "The activity of Rhizomuchor miehei lipase as a biocatalyst in enzymatic acylation of cyclic alcohol",

abstract = "We report the activity of Rhizomuchor miehei lipase (RML) as a biocatalyst, in particular the investigations concerning the effort of substrate-structure reactivity on the enzymatic acylation. The acylation was studied using acetic anhydride as an acyl donor and performed in n-hexane as a solvent. The selectivity of the enzymatic acylation was revealed by Gas Chromatography-Mass Spectra. We observed that, RML has shown different behavior when catalyzing the acylation of isopulegol and mixture of isopulegol and citronellal (ratio 1:1). The chemoselectivity for the O-acylation was improved when the acyl acceptor included mixture of isopulegol and citronellal.",

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Iftitah, ED, Srihardyastuti, A & Ariefin, M 2017, The activity of Rhizomuchor miehei lipase as a biocatalyst in enzymatic acylation of cyclic alcohol. in I Fatimah & G Purwiandono (eds), International Conference on Chemistry, Chemical Process and Engineering, IC3PE 2017., 020117, AIP Conference Proceedings, vol. 1823, American Institute of Physics Inc., International Conference on Chemistry, Chemical Process and Engineering, IC3PE 2017, Yogyakarta, Indonesia, 15/11/16. https://doi.org/10.1063/1.4978190

The activity of Rhizomuchor miehei lipase as a biocatalyst in enzymatic acylation of cyclic alcohol. / Iftitah, Elvina Dhiaul; Srihardyastuti, Arie; Ariefin, Mokhamat.
International Conference on Chemistry, Chemical Process and Engineering, IC3PE 2017. ed. / Is Fatimah; Gani Purwiandono. American Institute of Physics Inc., 2017. 020117 (AIP Conference Proceedings; Vol. 1823).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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T1 - The activity of Rhizomuchor miehei lipase as a biocatalyst in enzymatic acylation of cyclic alcohol

AU - Iftitah, Elvina Dhiaul

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AU - Ariefin, Mokhamat

PY - 2017/3/17

Y1 - 2017/3/17

N2 - We report the activity of Rhizomuchor miehei lipase (RML) as a biocatalyst, in particular the investigations concerning the effort of substrate-structure reactivity on the enzymatic acylation. The acylation was studied using acetic anhydride as an acyl donor and performed in n-hexane as a solvent. The selectivity of the enzymatic acylation was revealed by Gas Chromatography-Mass Spectra. We observed that, RML has shown different behavior when catalyzing the acylation of isopulegol and mixture of isopulegol and citronellal (ratio 1:1). The chemoselectivity for the O-acylation was improved when the acyl acceptor included mixture of isopulegol and citronellal.

AB - We report the activity of Rhizomuchor miehei lipase (RML) as a biocatalyst, in particular the investigations concerning the effort of substrate-structure reactivity on the enzymatic acylation. The acylation was studied using acetic anhydride as an acyl donor and performed in n-hexane as a solvent. The selectivity of the enzymatic acylation was revealed by Gas Chromatography-Mass Spectra. We observed that, RML has shown different behavior when catalyzing the acylation of isopulegol and mixture of isopulegol and citronellal (ratio 1:1). The chemoselectivity for the O-acylation was improved when the acyl acceptor included mixture of isopulegol and citronellal.

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U2 - 10.1063/1.4978190

DO - 10.1063/1.4978190

M3 - Conference contribution

AN - SCOPUS:85017519193

T3 - AIP Conference Proceedings

BT - International Conference on Chemistry, Chemical Process and Engineering, IC3PE 2017

A2 - Fatimah, Is

A2 - Purwiandono, Gani

PB - American Institute of Physics Inc.

T2 - International Conference on Chemistry, Chemical Process and Engineering, IC3PE 2017

Y2 - 15 November 2016 through 16 November 2016

ER -

The activity of Rhizomuchor miehei lipase as a biocatalyst in enzymatic acylation of cyclic alcohol

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