Synthesis and structure-activity relationship of 1-allyl-3-(2-chlorobenzoyl) thiourea as analgesic

Alvan F. Shalas; Siswandono; Marcellino Rudyanto

Synthesis and structure-activity relationship of 1-allyl-3-(2-chlorobenzoyl) thiourea as analgesic

Alvan F. Shalas^*
, Siswandono
, Marcellino Rudyanto

^*Corresponding author for this work

Faculty of Medicine

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Objective: The research was aimed to synthesize 1-allyl-3-(2-chlorobenzoyl) thiourea and determine its analgesic activity in mice (Mus musculus). Methods: The synthesis was carried out by modified Schotten-Baumann reaction, via nucleophilic substitution reaction of allylthiourea on 2-chlorobenzoyl chloride. The analgesic test was done by writhing test on mice (Mus musculus). Results: Pure 1-allyl-3-(2-chlorobenzoyl) thiourea was obtained, confirmed by means of UV, IR,¹H-NMR,¹³C-NMR, and MS spectroscopy. The compound showed better pain inhibition activity compared to diclofenac sodium, with ED₅₀ = 15.440 mg/kg BW. Conclusion: The compound 1-allyl-3-(2-chlorobenzoyl) thiourea can be synthesized by one-step modified Schotten-Baumann reaction, and showed a good analgesic activity. The compound needs further investigation as a potential analgesic drug candidate.

Original language	English
Pages (from-to)	297-298
Number of pages	2
Journal	International Journal of Pharmacy and Pharmaceutical Sciences
Volume	8
Issue number	6
Publication status	Published - 2016

Keywords

1-allyl-3-(2-chlorobenzoyl)thiourea
Analgesic activity
Modified schotten-baumann

Cite this

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title = "Synthesis and structure-activity relationship of 1-allyl-3-(2-chlorobenzoyl) thiourea as analgesic",

abstract = "Objective: The research was aimed to synthesize 1-allyl-3-(2-chlorobenzoyl) thiourea and determine its analgesic activity in mice (Mus musculus). Methods: The synthesis was carried out by modified Schotten-Baumann reaction, via nucleophilic substitution reaction of allylthiourea on 2-chlorobenzoyl chloride. The analgesic test was done by writhing test on mice (Mus musculus). Results: Pure 1-allyl-3-(2-chlorobenzoyl) thiourea was obtained, confirmed by means of UV, IR,1H-NMR,13C-NMR, and MS spectroscopy. The compound showed better pain inhibition activity compared to diclofenac sodium, with ED50 = 15.440 mg/kg BW. Conclusion: The compound 1-allyl-3-(2-chlorobenzoyl) thiourea can be synthesized by one-step modified Schotten-Baumann reaction, and showed a good analgesic activity. The compound needs further investigation as a potential analgesic drug candidate.",

keywords = "1-allyl-3-(2-chlorobenzoyl)thiourea, Analgesic activity, Modified schotten-baumann",

author = "Shalas, \{Alvan F.\} and Siswandono and Marcellino Rudyanto",

note = "Publisher Copyright: {\textcopyright} 2016 The Authors.",

year = "2016",

language = "English",

volume = "8",

pages = "297--298",

journal = "International Journal of Pharmacy and Pharmaceutical Sciences",

issn = "0975-1491",

publisher = "Innovare Academics Sciences Pvt. Ltd",

number = "6",

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TY - JOUR

T1 - Synthesis and structure-activity relationship of 1-allyl-3-(2-chlorobenzoyl) thiourea as analgesic

AU - Shalas, Alvan F.

AU - Siswandono,

AU - Rudyanto, Marcellino

PY - 2016

Y1 - 2016

N2 - Objective: The research was aimed to synthesize 1-allyl-3-(2-chlorobenzoyl) thiourea and determine its analgesic activity in mice (Mus musculus). Methods: The synthesis was carried out by modified Schotten-Baumann reaction, via nucleophilic substitution reaction of allylthiourea on 2-chlorobenzoyl chloride. The analgesic test was done by writhing test on mice (Mus musculus). Results: Pure 1-allyl-3-(2-chlorobenzoyl) thiourea was obtained, confirmed by means of UV, IR,1H-NMR,13C-NMR, and MS spectroscopy. The compound showed better pain inhibition activity compared to diclofenac sodium, with ED50 = 15.440 mg/kg BW. Conclusion: The compound 1-allyl-3-(2-chlorobenzoyl) thiourea can be synthesized by one-step modified Schotten-Baumann reaction, and showed a good analgesic activity. The compound needs further investigation as a potential analgesic drug candidate.

AB - Objective: The research was aimed to synthesize 1-allyl-3-(2-chlorobenzoyl) thiourea and determine its analgesic activity in mice (Mus musculus). Methods: The synthesis was carried out by modified Schotten-Baumann reaction, via nucleophilic substitution reaction of allylthiourea on 2-chlorobenzoyl chloride. The analgesic test was done by writhing test on mice (Mus musculus). Results: Pure 1-allyl-3-(2-chlorobenzoyl) thiourea was obtained, confirmed by means of UV, IR,1H-NMR,13C-NMR, and MS spectroscopy. The compound showed better pain inhibition activity compared to diclofenac sodium, with ED50 = 15.440 mg/kg BW. Conclusion: The compound 1-allyl-3-(2-chlorobenzoyl) thiourea can be synthesized by one-step modified Schotten-Baumann reaction, and showed a good analgesic activity. The compound needs further investigation as a potential analgesic drug candidate.

KW - 1-allyl-3-(2-chlorobenzoyl)thiourea

KW - Analgesic activity

KW - Modified schotten-baumann

UR - https://www.scopus.com/pages/publications/84971440615

M3 - Article

AN - SCOPUS:84971440615

SN - 0975-1491

VL - 8

SP - 297

EP - 298

JO - International Journal of Pharmacy and Pharmaceutical Sciences

JF - International Journal of Pharmacy and Pharmaceutical Sciences

IS - 6

ER -

Synthesis and structure-activity relationship of 1-allyl-3-(2-chlorobenzoyl) thiourea as analgesic

Abstract

Keywords

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