Role of circulating interleukin-17 level in progression of mitral regurgitation in pediatric patient with rheumatic heart disease

Ratih Kusumawardani; Renny Suwarniaty; Shahdevi N. Kurniawan

doi:10.1063/5.0053116

Role of circulating interleukin-17 level in progression of mitral regurgitation in pediatric patient with rheumatic heart disease

Ratih Kusumawardani^*
, Renny Suwarniaty
, Shahdevi N. Kurniawan

^*Corresponding author for this work

Faculty of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Citation (Scopus)

Abstract

Rheumatic heart disease (RHO) is a sequela of acute rheumatic fever (ARF) caused by the delayed immune response after group A β-hemolytic Streptococcus (GABHS) infection. It is the most frequent etiology of permanent heart valve damage in pediatrics, especially in the mitral valve. Interleukin-17 (IL-17) is cytokines that associate with the pathogenesis of RHO. Repeated exposure to GAHBS with an excessive Th17 response is thought to trigger inflammation, which will increase the severity of valve damage in RHO. This study aims to determine how circulating IL-17 level plays a part in the progression of mitral regurgitation (MR) in pediatric patient with RHO. The cross-sectional study included children 5-18 years diagnosed with ARF and RHO divided into 4 groups: mild, moderate, severe MR, and ARF without heart valve damage. ELISA method was employed to observe IL-17 levels, and comparison was made in each group. The levels of circulating IL-17 had a significant difference compared to each group of MRs (p = 0.000). Increasing IL-17 level associated with worse degree of MR with a strong positive correlation (p = 0.000, r = 0.638). There was a positive correlation of circulating IL-17 level and progression MR in the pediatric patient with RHD.

Original language	English
Title of host publication	International Conference on Life Sciences and Technology, ICoLiST 2020
Editors	Ahmad Taufiq, Hendra Susanto, Hadi Nur, Muhammad Aziz, Acharee Suksuwan, Chen Siang Ng, Khairunadwa Binti Jemon, Mohamad Amin, Markus Diantoro, Nandang Mufti, Nik Ahmad Nizam Nik Malek, I. Ching Wang, Sunaryono, Siti Zubaidah, Aulanni'am, Indra Wibowo, Adeodatus Yuda Handaya
Publisher	American Institute of Physics Inc.
ISBN (Electronic)	9780735440968
DOIs	https://doi.org/10.1063/5.0053116
Publication status	Published - 25 May 2021
Event	3rd International Conference on Life Sciences and Technology, ICoLiST 2020 - Malang, Indonesia Duration: 29 Sept 2020 → …

Publication series

Name	AIP Conference Proceedings
Volume	2353
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	3rd International Conference on Life Sciences and Technology, ICoLiST 2020
Country/Territory	Indonesia
City	Malang
Period	29/09/20 → …

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1063/5.0053116

Cite this

Kusumawardani, R., Suwarniaty, R., & Kurniawan, S. N. (2021). Role of circulating interleukin-17 level in progression of mitral regurgitation in pediatric patient with rheumatic heart disease. In A. Taufiq, H. Susanto, H. Nur, M. Aziz, A. Suksuwan, C. S. Ng, K. B. Jemon, M. Amin, M. Diantoro, N. Mufti, N. A. N. N. Malek, I. C. Wang, Sunaryono, S. Zubaidah, Aulanni'am, I. Wibowo, & A. Y. Handaya (Eds.), International Conference on Life Sciences and Technology, ICoLiST 2020 Article 030055 (AIP Conference Proceedings; Vol. 2353). American Institute of Physics Inc.. https://doi.org/10.1063/5.0053116

Kusumawardani, Ratih ; Suwarniaty, Renny ; Kurniawan, Shahdevi N. / Role of circulating interleukin-17 level in progression of mitral regurgitation in pediatric patient with rheumatic heart disease. International Conference on Life Sciences and Technology, ICoLiST 2020. editor / Ahmad Taufiq ; Hendra Susanto ; Hadi Nur ; Muhammad Aziz ; Acharee Suksuwan ; Chen Siang Ng ; Khairunadwa Binti Jemon ; Mohamad Amin ; Markus Diantoro ; Nandang Mufti ; Nik Ahmad Nizam Nik Malek ; I. Ching Wang ; Sunaryono ; Siti Zubaidah ; Aulanni'am ; Indra Wibowo ; Adeodatus Yuda Handaya. American Institute of Physics Inc., 2021. (AIP Conference Proceedings).

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title = "Role of circulating interleukin-17 level in progression of mitral regurgitation in pediatric patient with rheumatic heart disease",

abstract = "Rheumatic heart disease (RHO) is a sequela of acute rheumatic fever (ARF) caused by the delayed immune response after group A β-hemolytic Streptococcus (GABHS) infection. It is the most frequent etiology of permanent heart valve damage in pediatrics, especially in the mitral valve. Interleukin-17 (IL-17) is cytokines that associate with the pathogenesis of RHO. Repeated exposure to GAHBS with an excessive Th17 response is thought to trigger inflammation, which will increase the severity of valve damage in RHO. This study aims to determine how circulating IL-17 level plays a part in the progression of mitral regurgitation (MR) in pediatric patient with RHO. The cross-sectional study included children 5-18 years diagnosed with ARF and RHO divided into 4 groups: mild, moderate, severe MR, and ARF without heart valve damage. ELISA method was employed to observe IL-17 levels, and comparison was made in each group. The levels of circulating IL-17 had a significant difference compared to each group of MRs (p = 0.000). Increasing IL-17 level associated with worse degree of MR with a strong positive correlation (p = 0.000, r = 0.638). There was a positive correlation of circulating IL-17 level and progression MR in the pediatric patient with RHD.",

author = "Ratih Kusumawardani and Renny Suwarniaty and Kurniawan, \{Shahdevi N.\}",

note = "Publisher Copyright: {\textcopyright} 2021 Author(s).; 3rd International Conference on Life Sciences and Technology, ICoLiST 2020 ; Conference date: 29-09-2020",

year = "2021",

month = may,

day = "25",

doi = "10.1063/5.0053116",

language = "English",

series = "AIP Conference Proceedings",

publisher = "American Institute of Physics Inc.",

editor = "Ahmad Taufiq and Hendra Susanto and Hadi Nur and Muhammad Aziz and Acharee Suksuwan and Ng, \{Chen Siang\} and Jemon, \{Khairunadwa Binti\} and Mohamad Amin and Markus Diantoro and Nandang Mufti and Malek, \{Nik Ahmad Nizam Nik\} and Wang, \{I. Ching\} and Sunaryono and Siti Zubaidah and Aulanni'am and Indra Wibowo and Handaya, \{Adeodatus Yuda\}",

booktitle = "International Conference on Life Sciences and Technology, ICoLiST 2020",

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Kusumawardani, R, Suwarniaty, R & Kurniawan, SN 2021, Role of circulating interleukin-17 level in progression of mitral regurgitation in pediatric patient with rheumatic heart disease. in A Taufiq, H Susanto, H Nur, M Aziz, A Suksuwan, CS Ng, KB Jemon, M Amin, M Diantoro, N Mufti, NANN Malek, IC Wang, Sunaryono, S Zubaidah, Aulanni'am, I Wibowo & AY Handaya (eds), International Conference on Life Sciences and Technology, ICoLiST 2020., 030055, AIP Conference Proceedings, vol. 2353, American Institute of Physics Inc., 3rd International Conference on Life Sciences and Technology, ICoLiST 2020, Malang, Indonesia, 29/09/20. https://doi.org/10.1063/5.0053116

Role of circulating interleukin-17 level in progression of mitral regurgitation in pediatric patient with rheumatic heart disease. / Kusumawardani, Ratih; Suwarniaty, Renny; Kurniawan, Shahdevi N.
International Conference on Life Sciences and Technology, ICoLiST 2020. ed. / Ahmad Taufiq; Hendra Susanto; Hadi Nur; Muhammad Aziz; Acharee Suksuwan; Chen Siang Ng; Khairunadwa Binti Jemon; Mohamad Amin; Markus Diantoro; Nandang Mufti; Nik Ahmad Nizam Nik Malek; I. Ching Wang; Sunaryono; Siti Zubaidah; Aulanni'am; Indra Wibowo; Adeodatus Yuda Handaya. American Institute of Physics Inc., 2021. 030055 (AIP Conference Proceedings; Vol. 2353).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Role of circulating interleukin-17 level in progression of mitral regurgitation in pediatric patient with rheumatic heart disease

AU - Kusumawardani, Ratih

AU - Suwarniaty, Renny

AU - Kurniawan, Shahdevi N.

PY - 2021/5/25

Y1 - 2021/5/25

N2 - Rheumatic heart disease (RHO) is a sequela of acute rheumatic fever (ARF) caused by the delayed immune response after group A β-hemolytic Streptococcus (GABHS) infection. It is the most frequent etiology of permanent heart valve damage in pediatrics, especially in the mitral valve. Interleukin-17 (IL-17) is cytokines that associate with the pathogenesis of RHO. Repeated exposure to GAHBS with an excessive Th17 response is thought to trigger inflammation, which will increase the severity of valve damage in RHO. This study aims to determine how circulating IL-17 level plays a part in the progression of mitral regurgitation (MR) in pediatric patient with RHO. The cross-sectional study included children 5-18 years diagnosed with ARF and RHO divided into 4 groups: mild, moderate, severe MR, and ARF without heart valve damage. ELISA method was employed to observe IL-17 levels, and comparison was made in each group. The levels of circulating IL-17 had a significant difference compared to each group of MRs (p = 0.000). Increasing IL-17 level associated with worse degree of MR with a strong positive correlation (p = 0.000, r = 0.638). There was a positive correlation of circulating IL-17 level and progression MR in the pediatric patient with RHD.

AB - Rheumatic heart disease (RHO) is a sequela of acute rheumatic fever (ARF) caused by the delayed immune response after group A β-hemolytic Streptococcus (GABHS) infection. It is the most frequent etiology of permanent heart valve damage in pediatrics, especially in the mitral valve. Interleukin-17 (IL-17) is cytokines that associate with the pathogenesis of RHO. Repeated exposure to GAHBS with an excessive Th17 response is thought to trigger inflammation, which will increase the severity of valve damage in RHO. This study aims to determine how circulating IL-17 level plays a part in the progression of mitral regurgitation (MR) in pediatric patient with RHO. The cross-sectional study included children 5-18 years diagnosed with ARF and RHO divided into 4 groups: mild, moderate, severe MR, and ARF without heart valve damage. ELISA method was employed to observe IL-17 levels, and comparison was made in each group. The levels of circulating IL-17 had a significant difference compared to each group of MRs (p = 0.000). Increasing IL-17 level associated with worse degree of MR with a strong positive correlation (p = 0.000, r = 0.638). There was a positive correlation of circulating IL-17 level and progression MR in the pediatric patient with RHD.

UR - https://www.scopus.com/pages/publications/85107282464

U2 - 10.1063/5.0053116

DO - 10.1063/5.0053116

M3 - Conference contribution

AN - SCOPUS:85107282464

T3 - AIP Conference Proceedings

BT - International Conference on Life Sciences and Technology, ICoLiST 2020

A2 - Taufiq, Ahmad

A2 - Susanto, Hendra

A2 - Nur, Hadi

A2 - Aziz, Muhammad

A2 - Suksuwan, Acharee

A2 - Ng, Chen Siang

A2 - Jemon, Khairunadwa Binti

A2 - Amin, Mohamad

A2 - Diantoro, Markus

A2 - Mufti, Nandang

A2 - Malek, Nik Ahmad Nizam Nik

A2 - Wang, I. Ching

A2 - Sunaryono, null

A2 - Zubaidah, Siti

A2 - Aulanni'am, null

A2 - Wibowo, Indra

A2 - Handaya, Adeodatus Yuda

PB - American Institute of Physics Inc.

T2 - 3rd International Conference on Life Sciences and Technology, ICoLiST 2020

Y2 - 29 September 2020

ER -

Kusumawardani R, Suwarniaty R, Kurniawan SN. Role of circulating interleukin-17 level in progression of mitral regurgitation in pediatric patient with rheumatic heart disease. In Taufiq A, Susanto H, Nur H, Aziz M, Suksuwan A, Ng CS, Jemon KB, Amin M, Diantoro M, Mufti N, Malek NANN, Wang IC, Sunaryono, Zubaidah S, Aulanni'am, Wibowo I, Handaya AY, editors, International Conference on Life Sciences and Technology, ICoLiST 2020. American Institute of Physics Inc. 2021. 030055. (AIP Conference Proceedings). doi: 10.1063/5.0053116

Role of circulating interleukin-17 level in progression of mitral regurgitation in pediatric patient with rheumatic heart disease

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