Rat induced thyroiditis for experimental animal models: Comparative study of caprine thyroglobulin injection and sodium iodine (NaI) supplementation

Autoimmune thyroiditis is known to have some causes that need to be observed, including due to the influence of antigens that play a role in the development of this disease, namely thyroglobulin and iodide excess in the body. This study aimed to develop animal models of AITD using injection of thyroid protein goats (Capra hircus) and supplementation of Sodium Iodide (Nal). Thyroid protein is known to have a thyroglobulin as major parts of this gland. The development of diseases caused by two distinct inducer will be studied to determine the appropriate methods of AITD detection. Four groups of animal models were used in this study: the control, grup which received supplementation of Nal as well as group which injected with goat thyroglobulin at a dose of 100 and 200 μg mL^-1. Histopathological of thyroid gland, serum protein profiles, the expression of IL-1 and thyroxine levels were observed to determine the progression of this disease. Results of this study showed that a dose of 200 μg mL^-1 thyroglobulin could induce a significant damage to the above parameters and verified the reproducibility. This results was better than induction by Nal supplementation.