Proposed Functional Activity of Bioactive Compounds from Spatholobus littoralis Hassk in LC-MS-MS and Silico Studies

Dodi Iskandar; Nashi Widodo; Warsito Warsito; Masruri Masruri; Rollando Rollando; Warsidah Warsidah; Yeyasa Poulorossi Pieter Antang

doi:10.4028/p-0uei8m

Proposed Functional Activity of Bioactive Compounds from Spatholobus littoralis Hassk in LC-MS-MS and Silico Studies

Dodi Iskandar
, Nashi Widodo
, Warsito Warsito
, Masruri Masruri^*
, Rollando Rollando
, Warsidah Warsidah
, Yeyasa Poulorossi Pieter Antang

^*Corresponding author for this work

Faculty of Mathematics and Natural Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

4 Citations (Scopus)

Abstract

Spatholobus littoralis Hassk has biological activities such as strong antioxidants, booster of Leydig cell enhancer and testosterone level booster in male Rattus norvegicus, wound healer on the white mouse incision and cytotoxic against cell culture MCF7, HepG2, T47D, WIDR, HTB, and HeLa. This present study predicts bioactive compounds from S. littoralis Hassk in silico. The methods comprise maceration, LCMS-MS, and tools (massylnx V4.1, ChemBio Office 2010, mzCloud MS/MS library, SwissADME, and STITCH). The nine proposed compounds (compound 2, 3, 4, 5, 6, 7, 8, 11, and 12) are predicted to bind and react with HCAR3 protein and have potential as a medicine for disease pellagra and distal hereditary motor neuronopathy type 2.

Original language	English
Title of host publication	Materials Science Forum
Publisher	Trans Tech Publications Ltd
Pages	181-186
Number of pages	6
DOIs	https://doi.org/10.4028/p-0uei8m
Publication status	Published - 2022

Publication series

Name	Materials Science Forum
Volume	1061
ISSN (Print)	0255-5476
ISSN (Electronic)	1662-9752

Keywords

bioactive compounds
HCAR3
Spatholobus littoralis Hassk

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10.4028/p-0uei8m

Cite this

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title = "Proposed Functional Activity of Bioactive Compounds from Spatholobus littoralis Hassk in LC-MS-MS and Silico Studies",

abstract = "Spatholobus littoralis Hassk has biological activities such as strong antioxidants, booster of Leydig cell enhancer and testosterone level booster in male Rattus norvegicus, wound healer on the white mouse incision and cytotoxic against cell culture MCF7, HepG2, T47D, WIDR, HTB, and HeLa. This present study predicts bioactive compounds from S. littoralis Hassk in silico. The methods comprise maceration, LCMS-MS, and tools (massylnx V4.1, ChemBio Office 2010, mzCloud MS/MS library, SwissADME, and STITCH). The nine proposed compounds (compound 2, 3, 4, 5, 6, 7, 8, 11, and 12) are predicted to bind and react with HCAR3 protein and have potential as a medicine for disease pellagra and distal hereditary motor neuronopathy type 2.",

keywords = "bioactive compounds, HCAR3, Spatholobus littoralis Hassk",

author = "Dodi Iskandar and Nashi Widodo and Warsito Warsito and Masruri Masruri and Rollando Rollando and Warsidah Warsidah and Antang, \{Yeyasa Poulorossi Pieter\}",

note = "Publisher Copyright: {\textcopyright} 2022 Trans Tech Publications Ltd, Switzerland.",

year = "2022",

doi = "10.4028/p-0uei8m",

language = "English",

series = "Materials Science Forum",

publisher = "Trans Tech Publications Ltd",

pages = "181--186",

booktitle = "Materials Science Forum",

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Proposed Functional Activity of Bioactive Compounds from Spatholobus littoralis Hassk in LC-MS-MS and Silico Studies. / Iskandar, Dodi; Widodo, Nashi; Warsito, Warsito et al.
Materials Science Forum. Trans Tech Publications Ltd, 2022. p. 181-186 (Materials Science Forum; Vol. 1061).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

TY - CHAP

T1 - Proposed Functional Activity of Bioactive Compounds from Spatholobus littoralis Hassk in LC-MS-MS and Silico Studies

AU - Iskandar, Dodi

AU - Widodo, Nashi

AU - Warsito, Warsito

AU - Masruri, Masruri

AU - Rollando, Rollando

AU - Warsidah, Warsidah

AU - Antang, Yeyasa Poulorossi Pieter

PY - 2022

Y1 - 2022

N2 - Spatholobus littoralis Hassk has biological activities such as strong antioxidants, booster of Leydig cell enhancer and testosterone level booster in male Rattus norvegicus, wound healer on the white mouse incision and cytotoxic against cell culture MCF7, HepG2, T47D, WIDR, HTB, and HeLa. This present study predicts bioactive compounds from S. littoralis Hassk in silico. The methods comprise maceration, LCMS-MS, and tools (massylnx V4.1, ChemBio Office 2010, mzCloud MS/MS library, SwissADME, and STITCH). The nine proposed compounds (compound 2, 3, 4, 5, 6, 7, 8, 11, and 12) are predicted to bind and react with HCAR3 protein and have potential as a medicine for disease pellagra and distal hereditary motor neuronopathy type 2.

AB - Spatholobus littoralis Hassk has biological activities such as strong antioxidants, booster of Leydig cell enhancer and testosterone level booster in male Rattus norvegicus, wound healer on the white mouse incision and cytotoxic against cell culture MCF7, HepG2, T47D, WIDR, HTB, and HeLa. This present study predicts bioactive compounds from S. littoralis Hassk in silico. The methods comprise maceration, LCMS-MS, and tools (massylnx V4.1, ChemBio Office 2010, mzCloud MS/MS library, SwissADME, and STITCH). The nine proposed compounds (compound 2, 3, 4, 5, 6, 7, 8, 11, and 12) are predicted to bind and react with HCAR3 protein and have potential as a medicine for disease pellagra and distal hereditary motor neuronopathy type 2.

KW - bioactive compounds

KW - HCAR3

KW - Spatholobus littoralis Hassk

UR - https://www.scopus.com/pages/publications/85131725691

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DO - 10.4028/p-0uei8m

M3 - Chapter

AN - SCOPUS:85131725691

T3 - Materials Science Forum

SP - 181

EP - 186

BT - Materials Science Forum

PB - Trans Tech Publications Ltd

ER -

Proposed Functional Activity of Bioactive Compounds from Spatholobus littoralis Hassk in LC-MS-MS and Silico Studies

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Keywords

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