Possible effect of tea plant parasite, Scurrula atropurpurea (Blume) Danser, on growth inhibition of culture HeLa cells in vitro through DNA repair and apoptosis intrinsic pathways mechanism

Ni Wayan Manik Parwati; I. Komang Lindayani; Retty Ratnawati; Sri Winarsih; Tatit Nurseta

doi:10.1016/S2222-1808(15)60924-0

Possible effect of tea plant parasite, Scurrula atropurpurea (Blume) Danser, on growth inhibition of culture HeLa cells in vitro through DNA repair and apoptosis intrinsic pathways mechanism

Ni Wayan Manik Parwati
, I. Komang Lindayani
, Retty Ratnawati
, Sri Winarsih
, Tatit Nurseta^*

^*Corresponding author for this work

Faculty of Medicine

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Objective: To study the possible in vitro effect of tea plant parasite [. Scurrula atropurpurea (Blume) Danser] extract on HeLa cells culture growth inhibition through DNA repair and apoptosis intrinsic pathways mechanism. Methods: Flow cytometry assay were performed for those analyses. Results: For DNA repair pathway mechanism, treatment of tea plant parasite extract decreased MDM2 expression and increased p21 expression. And for apoptosis markers measurement on bax and bcl-2 showed an opposite result, increasing on bax and decreasing on bcl-2 expression. Almost all doses treatment in all measurement showed significantly result. Conclusions: This result showed an effect of tea plant parasite extract on inhibition of cells HeLa culture growth through DNA repair and apoptosis intrinsic pathways mechanism.

Original language	English
Pages (from-to)	743-746
Number of pages	4
Journal	Asian Pacific Journal of Tropical Disease
Volume	5
Issue number	9
DOIs	https://doi.org/10.1016/S2222-1808(15)60924-0
Publication status	Published - 1 Sept 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Apoptosis intrinsic pathways
Cervix cancers
DNA repairs pathways
HeLa cells
Scurrula antropurpurea

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10.1016/S2222-1808(15)60924-0

Cite this

Parwati, N. W. M., Lindayani, I. K., Ratnawati, R., Winarsih, S., & Nurseta, T. (2015). Possible effect of tea plant parasite, Scurrula atropurpurea (Blume) Danser, on growth inhibition of culture HeLa cells in vitro through DNA repair and apoptosis intrinsic pathways mechanism. Asian Pacific Journal of Tropical Disease, 5(9), 743-746. https://doi.org/10.1016/S2222-1808(15)60924-0

@article{cba00a5a4cda43798b32a092c49b7e6d,

title = "Possible effect of tea plant parasite, Scurrula atropurpurea (Blume) Danser, on growth inhibition of culture HeLa cells in vitro through DNA repair and apoptosis intrinsic pathways mechanism",

abstract = "Objective: To study the possible in vitro effect of tea plant parasite [. Scurrula atropurpurea (Blume) Danser] extract on HeLa cells culture growth inhibition through DNA repair and apoptosis intrinsic pathways mechanism. Methods: Flow cytometry assay were performed for those analyses. Results: For DNA repair pathway mechanism, treatment of tea plant parasite extract decreased MDM2 expression and increased p21 expression. And for apoptosis markers measurement on bax and bcl-2 showed an opposite result, increasing on bax and decreasing on bcl-2 expression. Almost all doses treatment in all measurement showed significantly result. Conclusions: This result showed an effect of tea plant parasite extract on inhibition of cells HeLa culture growth through DNA repair and apoptosis intrinsic pathways mechanism.",

keywords = "Apoptosis intrinsic pathways, Cervix cancers, DNA repairs pathways, HeLa cells, Scurrula antropurpurea",

author = "Parwati, \{Ni Wayan Manik\} and Lindayani, \{I. Komang\} and Retty Ratnawati and Sri Winarsih and Tatit Nurseta",

note = "Publisher Copyright: {\textcopyright} 2015 Asian Pacific Tropical Medicine Press.",

year = "2015",

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day = "1",

doi = "10.1016/S2222-1808(15)60924-0",

language = "English",

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Parwati, NWM, Lindayani, IK, Ratnawati, R, Winarsih, S & Nurseta, T 2015, 'Possible effect of tea plant parasite, Scurrula atropurpurea (Blume) Danser, on growth inhibition of culture HeLa cells in vitro through DNA repair and apoptosis intrinsic pathways mechanism', Asian Pacific Journal of Tropical Disease, vol. 5, no. 9, pp. 743-746. https://doi.org/10.1016/S2222-1808(15)60924-0

Possible effect of tea plant parasite, Scurrula atropurpurea (Blume) Danser, on growth inhibition of culture HeLa cells in vitro through DNA repair and apoptosis intrinsic pathways mechanism. / Parwati, Ni Wayan Manik; Lindayani, I. Komang; Ratnawati, Retty et al.
In: Asian Pacific Journal of Tropical Disease, Vol. 5, No. 9, 01.09.2015, p. 743-746.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Possible effect of tea plant parasite, Scurrula atropurpurea (Blume) Danser, on growth inhibition of culture HeLa cells in vitro through DNA repair and apoptosis intrinsic pathways mechanism

AU - Parwati, Ni Wayan Manik

AU - Lindayani, I. Komang

AU - Ratnawati, Retty

AU - Winarsih, Sri

AU - Nurseta, Tatit

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Objective: To study the possible in vitro effect of tea plant parasite [. Scurrula atropurpurea (Blume) Danser] extract on HeLa cells culture growth inhibition through DNA repair and apoptosis intrinsic pathways mechanism. Methods: Flow cytometry assay were performed for those analyses. Results: For DNA repair pathway mechanism, treatment of tea plant parasite extract decreased MDM2 expression and increased p21 expression. And for apoptosis markers measurement on bax and bcl-2 showed an opposite result, increasing on bax and decreasing on bcl-2 expression. Almost all doses treatment in all measurement showed significantly result. Conclusions: This result showed an effect of tea plant parasite extract on inhibition of cells HeLa culture growth through DNA repair and apoptosis intrinsic pathways mechanism.

AB - Objective: To study the possible in vitro effect of tea plant parasite [. Scurrula atropurpurea (Blume) Danser] extract on HeLa cells culture growth inhibition through DNA repair and apoptosis intrinsic pathways mechanism. Methods: Flow cytometry assay were performed for those analyses. Results: For DNA repair pathway mechanism, treatment of tea plant parasite extract decreased MDM2 expression and increased p21 expression. And for apoptosis markers measurement on bax and bcl-2 showed an opposite result, increasing on bax and decreasing on bcl-2 expression. Almost all doses treatment in all measurement showed significantly result. Conclusions: This result showed an effect of tea plant parasite extract on inhibition of cells HeLa culture growth through DNA repair and apoptosis intrinsic pathways mechanism.

KW - Apoptosis intrinsic pathways

KW - Cervix cancers

KW - DNA repairs pathways

KW - HeLa cells

KW - Scurrula antropurpurea

UR - https://www.scopus.com/pages/publications/84939452424

U2 - 10.1016/S2222-1808(15)60924-0

DO - 10.1016/S2222-1808(15)60924-0

M3 - Article

AN - SCOPUS:84939452424

SN - 2222-1808

VL - 5

SP - 743

EP - 746

JO - Asian Pacific Journal of Tropical Disease

JF - Asian Pacific Journal of Tropical Disease

IS - 9

ER -

Possible effect of tea plant parasite, Scurrula atropurpurea (Blume) Danser, on growth inhibition of culture HeLa cells in vitro through DNA repair and apoptosis intrinsic pathways mechanism

Abstract

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Keywords

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