Pilot plant scale extraction of black cincau (Mesona palustris BL) using historical-data response surface methodology

This study successfully optimized the extraction time for dried ground leaf of black cincau (Mesona palustris BL) in extraction tank from 15 to 300 minutes, and the historical input data were used in this study. The optimum conditions for total phenolic compound (TPC), antioxidant activity and the cost of extraction process were evaluated using Historical-data Response Surface Methodology (RSM) by setting to maximum values and extract production cost to minimum values. The optimum extraction process was gained at 153.65 min or 2.5 hours with the predicted values of TPC, antioxidant activity and extraction cost were 1.636±0.12 mg CAE/g, 49.57±12.26%, 1.733x106 IDR, respectively. Small deviation between experimental values and predicted values was obtained, i.e 1.574 + 0.06 mg CAE /g, 49.51 + 12.26% and 1,734x106 (IDR). This study showed that optimizing the extraction time in pilot-scale for black cincau extract using Historical-data RSM is accurate and feasible to be commercialized.