Pilot Evaluation of Endothelin-1 and TG/HDL-C Ratio for Early Cardiovascular Risk Stratification in Adiposity-Based and Cardiovascular-Kidney-Metabolic Syndromes

Aldian Arie Pratama; Agustin Iskandar; Singgih Pudjo Wahono

doi:10.33678/cor.2025.085

Pilot Evaluation of Endothelin-1 and TG/HDL-C Ratio for Early Cardiovascular Risk Stratification in Adiposity-Based and Cardiovascular-Kidney-Metabolic Syndromes

Aldian Arie Pratama^*
, Agustin Iskandar
, Singgih Pudjo Wahono

^*Corresponding author for this work

Faculty of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Adiposity-related chronic diseases and cardiovascular-kidney-metabolic (CKM) syndrome significantly contribute to the burden of non-communicable diseases (NCDs), especially in low-and middle-income countries (LMICs), where early risk stratification is still inadequate. This study evaluated the efficacy of endothelin-1 (ET-1) and the triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio as early, cost-efficient biomarkers for cardiovascular risk assessment in persons with adiposity-based chronic disease (ABCD) and early-stage CKM syndrome.

Original language	English
Pages (from-to)	51-60
Number of pages	10
Journal	Cor et Vasa
Volume	68
Issue number	1
DOIs	https://doi.org/10.33678/cor.2025.085
Publication status	Published - 2026

Keywords

Adiposity-based chronic disease
Atherogenic index of plasma
Cardiovascular risk assessment
Cardiovascular-kidney-metabolic syndrome
Endothelin-1
Triglyceride-to-HDL cholesterol ratio

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10.33678/cor.2025.085

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title = "Pilot Evaluation of Endothelin-1 and TG/HDL-C Ratio for Early Cardiovascular Risk Stratification in Adiposity-Based and Cardiovascular-Kidney-Metabolic Syndromes",

abstract = "Adiposity-related chronic diseases and cardiovascular-kidney-metabolic (CKM) syndrome significantly contribute to the burden of non-communicable diseases (NCDs), especially in low-and middle-income countries (LMICs), where early risk stratification is still inadequate. This study evaluated the efficacy of endothelin-1 (ET-1) and the triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio as early, cost-efficient biomarkers for cardiovascular risk assessment in persons with adiposity-based chronic disease (ABCD) and early-stage CKM syndrome.",

keywords = "Adiposity-based chronic disease, Atherogenic index of plasma, Cardiovascular risk assessment, Cardiovascular-kidney-metabolic syndrome, Endothelin-1, Triglyceride-to-HDL cholesterol ratio",

author = "Pratama, \{Aldian Arie\} and Agustin Iskandar and Wahono, \{Singgih Pudjo\}",

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year = "2026",

doi = "10.33678/cor.2025.085",

language = "English",

volume = "68",

pages = "51--60",

journal = "Cor et Vasa",

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AU - Pratama, Aldian Arie

AU - Iskandar, Agustin

AU - Wahono, Singgih Pudjo

PY - 2026

Y1 - 2026

N2 - Adiposity-related chronic diseases and cardiovascular-kidney-metabolic (CKM) syndrome significantly contribute to the burden of non-communicable diseases (NCDs), especially in low-and middle-income countries (LMICs), where early risk stratification is still inadequate. This study evaluated the efficacy of endothelin-1 (ET-1) and the triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio as early, cost-efficient biomarkers for cardiovascular risk assessment in persons with adiposity-based chronic disease (ABCD) and early-stage CKM syndrome.

AB - Adiposity-related chronic diseases and cardiovascular-kidney-metabolic (CKM) syndrome significantly contribute to the burden of non-communicable diseases (NCDs), especially in low-and middle-income countries (LMICs), where early risk stratification is still inadequate. This study evaluated the efficacy of endothelin-1 (ET-1) and the triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio as early, cost-efficient biomarkers for cardiovascular risk assessment in persons with adiposity-based chronic disease (ABCD) and early-stage CKM syndrome.

KW - Adiposity-based chronic disease

KW - Atherogenic index of plasma

KW - Cardiovascular risk assessment

KW - Cardiovascular-kidney-metabolic syndrome

KW - Endothelin-1

KW - Triglyceride-to-HDL cholesterol ratio

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DO - 10.33678/cor.2025.085

M3 - Article

AN - SCOPUS:105037145172

SN - 0010-8650

VL - 68

SP - 51

EP - 60

JO - Cor et Vasa

JF - Cor et Vasa

IS - 1

ER -

Pilot Evaluation of Endothelin-1 and TG/HDL-C Ratio for Early Cardiovascular Risk Stratification in Adiposity-Based and Cardiovascular-Kidney-Metabolic Syndromes

Abstract

Keywords

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