TY - GEN
T1 - Morphology, Porosity, and Biodegradation of PVA/PEG/Chitosan Nanofiber Scaffolds for Skin Tissue Engineering
AU - Hartatiek, Hartatiek
AU - Yudyanto, Yudyanto
AU - Rahim, L. F.
AU - Amalia, S.
AU - Nurhuda, M.
AU - Masruroh, Masruroh
AU - Santjojo, Dionysius J.D.H.
N1 - Publisher Copyright:
© 2023 American Institute of Physics Inc.. All rights reserved.
PY - 2023/1/24
Y1 - 2023/1/24
N2 - This study aims to fabricate PVA/PEG/Chitosan nanofiber scaffolds for skin tissue engineering. The scaffolds in the nanofiber structure closely match with the ECM structure of the skin tissue. PVA/PEG/Chitosan nanofibers were prepared by electrospinning technique with various compositions (v/v) % (95:5, 90:10, 85:15, 80:20). The scaffold surface morphology was characterized by scanning electron microscopy (SEM), and the functional groups were characterized by Fourier transform infrared (FTIR). The biodegradation test was carried out by immersing the sample in a simulated body fluid (SBF) solution with time variations of 1,2,3, and 4 weeks. The scaffolds have diameters in the range of 110-520 nm, which correspond to the skin ECM, and porosity in the range of 63-71%, which facilitates cell adhesion, and proliferation. The rate of biodegradation is faster in the composition (95:5). The surface morphology with random fiber diameter, porosity, and biodegradation are suitable for skin tissue scaffolding.
AB - This study aims to fabricate PVA/PEG/Chitosan nanofiber scaffolds for skin tissue engineering. The scaffolds in the nanofiber structure closely match with the ECM structure of the skin tissue. PVA/PEG/Chitosan nanofibers were prepared by electrospinning technique with various compositions (v/v) % (95:5, 90:10, 85:15, 80:20). The scaffold surface morphology was characterized by scanning electron microscopy (SEM), and the functional groups were characterized by Fourier transform infrared (FTIR). The biodegradation test was carried out by immersing the sample in a simulated body fluid (SBF) solution with time variations of 1,2,3, and 4 weeks. The scaffolds have diameters in the range of 110-520 nm, which correspond to the skin ECM, and porosity in the range of 63-71%, which facilitates cell adhesion, and proliferation. The rate of biodegradation is faster in the composition (95:5). The surface morphology with random fiber diameter, porosity, and biodegradation are suitable for skin tissue scaffolding.
UR - https://www.scopus.com/pages/publications/85147285161
U2 - 10.1063/5.0111554
DO - 10.1063/5.0111554
M3 - Conference contribution
AN - SCOPUS:85147285161
T3 - AIP Conference Proceedings
BT - 4th International Conference on Life Science and Technology, ICoLiST 2023
A2 - Taufiq, Ahmad
A2 - Susanto, Hendra
A2 - Wang, I. Ching
A2 - Nur, Hadi
A2 - Aziz, Muhammad
A2 - Chang, Chuang-Rung
A2 - Elbers, Gereon
A2 - Lestari, Sri Rahayu
A2 - Diantoro, Markus
A2 - Mufti, Nandang
A2 - Ng, Chen Siang
A2 - Malek, Nik Ahmad Nizam Nik
A2 - Sunaryono, null
A2 - Chiu, Yu-Hsin
A2 - Zubaidah, Siti
A2 - Aulanni'am, null
A2 - Wibowo, Indra
A2 - Handaya, Adeodatus Yuda
PB - American Institute of Physics Inc.
T2 - 4th International Conference on Life Science and Technology, ICoLiST 2023
Y2 - 31 August 2021
ER -