TY - GEN
T1 - Morphology, porosity, and biodegradation of PVA/CS/PEG/HaP nanofiber composites as scaffold in bone tissue engineering
AU - Hartatiek,
AU - Yudyanto,
AU - Nada Shofura, F.
AU - Utomo, Joko
AU - Nurhuda, M.
AU - Santjojo, Dionysius J.D.H.
AU - Masruroh,
N1 - Publisher Copyright:
© 2020 American Institute of Physics Inc.. All rights reserved.
PY - 2020/4/21
Y1 - 2020/4/21
N2 - Hydroxyapatite (HAp) is a bioceramic that can be applied for bone tissue regeneration. The hydroxyapatite scaffold has poor biodegradation. To increase the biodegradation of HAp, we composited it with PVA, Chitosan, and PEG polymers, which have faster biodegradation properties. PVA/CS/PEG/HAp composites nanofibers as a scaffold in bone tissue engineering were prepared by electrospinning. The composition of HAp varied 0, 2, 3, 4, 5, and 6%. HAp was synthesized from natural deposits and characterized using X-Ray Diffraction (XRD) to obtain phase, crystallinity, and crystal size. Surface morphology and porosity of nanofiber composites were characterized by SEM-EDX. Previous studies without the addition of PEG produced less homogeneous nanofibers. Increasing the concentration of HAp and adding PEG could increase the average diameter of the nanofiber and reduce porosity. Composite biodegradation of PVA/CS/PEG/HAp was also evaluated. Biodegradation test was carried out by immersing the sample in Krebs solution prepared for 1-4 weeks, and the fastest mass reduction occurred in HAp (0%) and decreased with increasing concentration of HAp. This nanofiber HAp/CS/PEG/HAp composite can be applied as a scaffold in bone tissue engineering.
AB - Hydroxyapatite (HAp) is a bioceramic that can be applied for bone tissue regeneration. The hydroxyapatite scaffold has poor biodegradation. To increase the biodegradation of HAp, we composited it with PVA, Chitosan, and PEG polymers, which have faster biodegradation properties. PVA/CS/PEG/HAp composites nanofibers as a scaffold in bone tissue engineering were prepared by electrospinning. The composition of HAp varied 0, 2, 3, 4, 5, and 6%. HAp was synthesized from natural deposits and characterized using X-Ray Diffraction (XRD) to obtain phase, crystallinity, and crystal size. Surface morphology and porosity of nanofiber composites were characterized by SEM-EDX. Previous studies without the addition of PEG produced less homogeneous nanofibers. Increasing the concentration of HAp and adding PEG could increase the average diameter of the nanofiber and reduce porosity. Composite biodegradation of PVA/CS/PEG/HAp was also evaluated. Biodegradation test was carried out by immersing the sample in Krebs solution prepared for 1-4 weeks, and the fastest mass reduction occurred in HAp (0%) and decreased with increasing concentration of HAp. This nanofiber HAp/CS/PEG/HAp composite can be applied as a scaffold in bone tissue engineering.
UR - https://www.scopus.com/pages/publications/85092560473
U2 - 10.1063/5.0002678
DO - 10.1063/5.0002678
M3 - Conference contribution
AN - SCOPUS:85092560473
T3 - AIP Conference Proceedings
BT - International Conference on Life Science and Technology, ICoLiST 2019
A2 - Taufiq, Ahmad
A2 - Susanto, Hendra
A2 - Nur, Hadi
A2 - Aziz, Muhammad
A2 - Chang, Chuang-Rung
A2 - Lee, Hyohyemi
A2 - Diantoro, Markus
A2 - Mufti, Nandang
A2 - Malek, Nik Ahmad Nizam Nik
A2 - Wang, I. Ching
A2 - Iskandar, Djoko Tjahnono
A2 - Elbers, Gereon
A2 - Sunaryono, Sunaryono
A2 - Zubaidah, Siti
A2 - Sumari, Sumari
A2 - Aulanni'am, null
A2 - Nandiyanto, Asep Bayu
A2 - Wibowo, Indra
A2 - Handaya, Adeodatus Yuda
PB - American Institute of Physics Inc.
T2 - 2nd International Conference on Life Science and Technology, ICoLiST 2019
Y2 - 12 September 2019 through 13 September 2019
ER -