Mechanisms of cancer cell killing by sea cucumber-derived compounds

Teresa Liliana Wargasetia

doi:10.1007/s10637-017-0505-5

Mechanisms of cancer cell killing by sea cucumber-derived compounds

Teresa Liliana Wargasetia^*
, Widodo

^*Corresponding author for this work

Faculty of Mathematics and Natural Sciences

Research output: Contribution to journal › Review article › peer-review

49 Citations (Scopus)

Abstract

The aim of cancer therapy is to specifically eradicate tumor cells while causing minimal damage to normal tissues and minimal side-effects. Because of this, the use of natural substances with low toxicity is a good option. Sea cucumbers are one of many potential marine animals that contain valuable nutrients and medicinal properties. The medicinal value of sea cucumbers is attributed to the presence of bioactive agents with promising biological and pharmacological properties that include cytotoxic activity, induction of apoptosis, cell cycle arrest, inhibition of tumor growth, anti-metastatic and anti-angiogenic properties, and inhibition of drug resistance. This review discusses the mechanisms of cancer cell death induced by sea cucumber-derived compounds with regard to exploring the potential use of these marine natural products for cancer therapy.

Original language	English
Pages (from-to)	820-826
Number of pages	7
Journal	Investigational New Drugs
Volume	35
Issue number	6
DOIs	https://doi.org/10.1007/s10637-017-0505-5
Publication status	Published - 1 Dec 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anti-cancer, apoptosis, metastasis
Sea cucumbers
Triterpene glycosides

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10.1007/s10637-017-0505-5

Cite this

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title = "Mechanisms of cancer cell killing by sea cucumber-derived compounds",

abstract = "The aim of cancer therapy is to specifically eradicate tumor cells while causing minimal damage to normal tissues and minimal side-effects. Because of this, the use of natural substances with low toxicity is a good option. Sea cucumbers are one of many potential marine animals that contain valuable nutrients and medicinal properties. The medicinal value of sea cucumbers is attributed to the presence of bioactive agents with promising biological and pharmacological properties that include cytotoxic activity, induction of apoptosis, cell cycle arrest, inhibition of tumor growth, anti-metastatic and anti-angiogenic properties, and inhibition of drug resistance. This review discusses the mechanisms of cancer cell death induced by sea cucumber-derived compounds with regard to exploring the potential use of these marine natural products for cancer therapy.",

keywords = "Anti-cancer, apoptosis, metastasis, Sea cucumbers, Triterpene glycosides",

author = "Wargasetia, \{Teresa Liliana\} and Widodo",

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T1 - Mechanisms of cancer cell killing by sea cucumber-derived compounds

AU - Wargasetia, Teresa Liliana

AU - Widodo,

PY - 2017/12/1

Y1 - 2017/12/1

N2 - The aim of cancer therapy is to specifically eradicate tumor cells while causing minimal damage to normal tissues and minimal side-effects. Because of this, the use of natural substances with low toxicity is a good option. Sea cucumbers are one of many potential marine animals that contain valuable nutrients and medicinal properties. The medicinal value of sea cucumbers is attributed to the presence of bioactive agents with promising biological and pharmacological properties that include cytotoxic activity, induction of apoptosis, cell cycle arrest, inhibition of tumor growth, anti-metastatic and anti-angiogenic properties, and inhibition of drug resistance. This review discusses the mechanisms of cancer cell death induced by sea cucumber-derived compounds with regard to exploring the potential use of these marine natural products for cancer therapy.

AB - The aim of cancer therapy is to specifically eradicate tumor cells while causing minimal damage to normal tissues and minimal side-effects. Because of this, the use of natural substances with low toxicity is a good option. Sea cucumbers are one of many potential marine animals that contain valuable nutrients and medicinal properties. The medicinal value of sea cucumbers is attributed to the presence of bioactive agents with promising biological and pharmacological properties that include cytotoxic activity, induction of apoptosis, cell cycle arrest, inhibition of tumor growth, anti-metastatic and anti-angiogenic properties, and inhibition of drug resistance. This review discusses the mechanisms of cancer cell death induced by sea cucumber-derived compounds with regard to exploring the potential use of these marine natural products for cancer therapy.

KW - Anti-cancer, apoptosis, metastasis

KW - Sea cucumbers

KW - Triterpene glycosides

UR - https://www.scopus.com/pages/publications/85029576694

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DO - 10.1007/s10637-017-0505-5

M3 - Review article

C2 - 28920157

AN - SCOPUS:85029576694

SN - 0167-6997

VL - 35

SP - 820

EP - 826

JO - Investigational New Drugs

JF - Investigational New Drugs

IS - 6

ER -

Mechanisms of cancer cell killing by sea cucumber-derived compounds

Abstract

UN SDGs

Keywords

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