Light Exposure’s Effects on Inactive Frequency and Distance Moved of Zebrafish in the Insomnia Model

Zamroni Afif; Dheka Sapti Iskandar; Annisatul Hakimah; Syafiatul Azizah; Nurvia Andriani; Kartika Agustina; Shahdevi Nandar Kurniawan; Husnul Khotimah; Irawan Satriotomo

doi:10.1063/5.0237816

Light Exposure’s Effects on Inactive Frequency and Distance Moved of Zebrafish in the Insomnia Model

Zamroni Afif
, Dheka Sapti Iskandar
, Annisatul Hakimah
, Syafiatul Azizah
, Nurvia Andriani
, Kartika Agustina
, Shahdevi Nandar Kurniawan
, Husnul Khotimah^*
, Irawan Satriotomo

^*Corresponding author for this work

Faculty of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Insomnia is inability to maintain or elevate sleep quality at least three times a day, more than three days in a week, or more than three months. One of theories that is explaining insomnia causes focuses on a condition called hyperarousal, which is related to increasing mental, cognitive, and motor activities. This study was applied to create the insomnia model, that zebrafish larvae were exposed to illumination with intensity of 200 lux. There were four phases of light exposure, consist of 12 hours of light with 12 hours of dark, and 18 hours of light with 6 hours of flash. The flash phase group was divided into two groups consist of 2 minutes light on with 2 minutes dark and 4 minutes light on with 1 minute dark. The result showed that the 24-hour treatment, both light and dark cycles, have a lower inactive frequency and a higher distance moved compared to the control group.

Original language	English
Title of host publication	AIP Conference Proceedings
Editors	Ahmad Taufiq, Hendra Susanto, Chuang-Rung Chang, I. Ching Wang, Hadi Nur, Muhammad Aziz, Sri Rahayu Lestari, Markus Diantoro, Nandang Mufti, Nik Ahmad Nizam Nik Malek, Sunaryono, Siti Zubaidah, Aulanni'am, Indra Wibowo, Adeodatus Yuda Handaya
Publisher	American Institute of Physics
Edition	1
ISBN (Electronic)	9780735451025
DOIs	https://doi.org/10.1063/5.0237816
Publication status	Published - 30 Jan 2025
Event	5th International Conference on Life Science and Technology, ICoLiST 2022 - Hybrid, Malang, Indonesia Duration: 30 Aug 2022 → 31 Aug 2022

Publication series

Name	AIP Conference Proceedings
Number	1
Volume	3186
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	5th International Conference on Life Science and Technology, ICoLiST 2022
Country/Territory	Indonesia
City	Hybrid, Malang
Period	30/08/22 → 31/08/22

Access to Document

10.1063/5.0237816

Cite this

Afif, Z., Iskandar, D. S., Hakimah, A., Azizah, S., Andriani, N., Agustina, K., Kurniawan, S. N., Khotimah, H., & Satriotomo, I. (2025). Light Exposure’s Effects on Inactive Frequency and Distance Moved of Zebrafish in the Insomnia Model. In A. Taufiq, H. Susanto, C.-R. Chang, I. C. Wang, H. Nur, M. Aziz, S. R. Lestari, M. Diantoro, N. Mufti, N. A. N. N. Malek, Sunaryono, S. Zubaidah, Aulanni'am, I. Wibowo, & A. Y. Handaya (Eds.), AIP Conference Proceedings (1 ed.). Article 020013 (AIP Conference Proceedings; Vol. 3186, No. 1). American Institute of Physics. https://doi.org/10.1063/5.0237816

Afif, Zamroni ; Iskandar, Dheka Sapti ; Hakimah, Annisatul et al. / Light Exposure’s Effects on Inactive Frequency and Distance Moved of Zebrafish in the Insomnia Model. AIP Conference Proceedings. editor / Ahmad Taufiq ; Hendra Susanto ; Chuang-Rung Chang ; I. Ching Wang ; Hadi Nur ; Muhammad Aziz ; Sri Rahayu Lestari ; Markus Diantoro ; Nandang Mufti ; Nik Ahmad Nizam Nik Malek ; Sunaryono ; Siti Zubaidah ; Aulanni'am ; Indra Wibowo ; Adeodatus Yuda Handaya. 1. ed. American Institute of Physics, 2025. (AIP Conference Proceedings; 1).

@inproceedings{68519fac0a5a496ba8aad93c19682fcc,

title = "Light Exposure{\textquoteright}s Effects on Inactive Frequency and Distance Moved of Zebrafish in the Insomnia Model",

abstract = "Insomnia is inability to maintain or elevate sleep quality at least three times a day, more than three days in a week, or more than three months. One of theories that is explaining insomnia causes focuses on a condition called hyperarousal, which is related to increasing mental, cognitive, and motor activities. This study was applied to create the insomnia model, that zebrafish larvae were exposed to illumination with intensity of 200 lux. There were four phases of light exposure, consist of 12 hours of light with 12 hours of dark, and 18 hours of light with 6 hours of flash. The flash phase group was divided into two groups consist of 2 minutes light on with 2 minutes dark and 4 minutes light on with 1 minute dark. The result showed that the 24-hour treatment, both light and dark cycles, have a lower inactive frequency and a higher distance moved compared to the control group.",

author = "Zamroni Afif and Iskandar, \{Dheka Sapti\} and Annisatul Hakimah and Syafiatul Azizah and Nurvia Andriani and Kartika Agustina and Kurniawan, \{Shahdevi Nandar\} and Husnul Khotimah and Irawan Satriotomo",

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day = "30",

doi = "10.1063/5.0237816",

language = "English",

series = "AIP Conference Proceedings",

publisher = "American Institute of Physics",

number = "1",

editor = "Ahmad Taufiq and Hendra Susanto and Chuang-Rung Chang and Wang, \{I. Ching\} and Hadi Nur and Muhammad Aziz and Lestari, \{Sri Rahayu\} and Markus Diantoro and Nandang Mufti and Malek, \{Nik Ahmad Nizam Nik\} and Sunaryono and Siti Zubaidah and Aulanni'am and Indra Wibowo and Handaya, \{Adeodatus Yuda\}",

booktitle = "AIP Conference Proceedings",

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Afif, Z, Iskandar, DS, Hakimah, A, Azizah, S, Andriani, N, Agustina, K, Kurniawan, SN , Khotimah, H & Satriotomo, I 2025, Light Exposure’s Effects on Inactive Frequency and Distance Moved of Zebrafish in the Insomnia Model. in A Taufiq, H Susanto, C-R Chang, IC Wang, H Nur, M Aziz, SR Lestari, M Diantoro, N Mufti, NANN Malek, Sunaryono, S Zubaidah, Aulanni'am, I Wibowo & AY Handaya (eds), AIP Conference Proceedings. 1 edn, 020013, AIP Conference Proceedings, no. 1, vol. 3186, American Institute of Physics, 5th International Conference on Life Science and Technology, ICoLiST 2022, Hybrid, Malang, Indonesia, 30/08/22. https://doi.org/10.1063/5.0237816

Light Exposure’s Effects on Inactive Frequency and Distance Moved of Zebrafish in the Insomnia Model. / Afif, Zamroni; Iskandar, Dheka Sapti; Hakimah, Annisatul et al.
AIP Conference Proceedings. ed. / Ahmad Taufiq; Hendra Susanto; Chuang-Rung Chang; I. Ching Wang; Hadi Nur; Muhammad Aziz; Sri Rahayu Lestari; Markus Diantoro; Nandang Mufti; Nik Ahmad Nizam Nik Malek; Sunaryono; Siti Zubaidah; Aulanni'am; Indra Wibowo; Adeodatus Yuda Handaya. 1. ed. American Institute of Physics, 2025. 020013 (AIP Conference Proceedings; Vol. 3186, No. 1).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Light Exposure’s Effects on Inactive Frequency and Distance Moved of Zebrafish in the Insomnia Model

AU - Afif, Zamroni

AU - Iskandar, Dheka Sapti

AU - Hakimah, Annisatul

AU - Azizah, Syafiatul

AU - Andriani, Nurvia

AU - Agustina, Kartika

AU - Kurniawan, Shahdevi Nandar

AU - Khotimah, Husnul

AU - Satriotomo, Irawan

PY - 2025/1/30

Y1 - 2025/1/30

N2 - Insomnia is inability to maintain or elevate sleep quality at least three times a day, more than three days in a week, or more than three months. One of theories that is explaining insomnia causes focuses on a condition called hyperarousal, which is related to increasing mental, cognitive, and motor activities. This study was applied to create the insomnia model, that zebrafish larvae were exposed to illumination with intensity of 200 lux. There were four phases of light exposure, consist of 12 hours of light with 12 hours of dark, and 18 hours of light with 6 hours of flash. The flash phase group was divided into two groups consist of 2 minutes light on with 2 minutes dark and 4 minutes light on with 1 minute dark. The result showed that the 24-hour treatment, both light and dark cycles, have a lower inactive frequency and a higher distance moved compared to the control group.

AB - Insomnia is inability to maintain or elevate sleep quality at least three times a day, more than three days in a week, or more than three months. One of theories that is explaining insomnia causes focuses on a condition called hyperarousal, which is related to increasing mental, cognitive, and motor activities. This study was applied to create the insomnia model, that zebrafish larvae were exposed to illumination with intensity of 200 lux. There were four phases of light exposure, consist of 12 hours of light with 12 hours of dark, and 18 hours of light with 6 hours of flash. The flash phase group was divided into two groups consist of 2 minutes light on with 2 minutes dark and 4 minutes light on with 1 minute dark. The result showed that the 24-hour treatment, both light and dark cycles, have a lower inactive frequency and a higher distance moved compared to the control group.

UR - https://www.scopus.com/pages/publications/85217638333

U2 - 10.1063/5.0237816

DO - 10.1063/5.0237816

M3 - Conference contribution

AN - SCOPUS:85217638333

T3 - AIP Conference Proceedings

BT - AIP Conference Proceedings

A2 - Taufiq, Ahmad

A2 - Susanto, Hendra

A2 - Chang, Chuang-Rung

A2 - Wang, I. Ching

A2 - Nur, Hadi

A2 - Aziz, Muhammad

A2 - Lestari, Sri Rahayu

A2 - Diantoro, Markus

A2 - Mufti, Nandang

A2 - Malek, Nik Ahmad Nizam Nik

A2 - Sunaryono, null

A2 - Zubaidah, Siti

A2 - Aulanni'am, null

A2 - Wibowo, Indra

A2 - Handaya, Adeodatus Yuda

PB - American Institute of Physics

T2 - 5th International Conference on Life Science and Technology, ICoLiST 2022

Y2 - 30 August 2022 through 31 August 2022

ER -

Afif Z, Iskandar DS, Hakimah A, Azizah S, Andriani N, Agustina K et al. Light Exposure’s Effects on Inactive Frequency and Distance Moved of Zebrafish in the Insomnia Model. In Taufiq A, Susanto H, Chang CR, Wang IC, Nur H, Aziz M, Lestari SR, Diantoro M, Mufti N, Malek NANN, Sunaryono, Zubaidah S, Aulanni'am, Wibowo I, Handaya AY, editors, AIP Conference Proceedings. 1 ed. American Institute of Physics. 2025. 020013. (AIP Conference Proceedings; 1). doi: 10.1063/5.0237816

Light Exposure’s Effects on Inactive Frequency and Distance Moved of Zebrafish in the Insomnia Model

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