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Interleukin-28B polymorphisms and response of chronic hepatitis C patients from Indonesia to pegylated interferon/ribavirin treatment

  • J. Juniastuti
  • , Bogi P. Wibowo
  • , I. D.N. Wibawa
  • , Takako Utsumi
  • , Syifa Mustika
  • , Mochamad Amin
  • , Rury M. Wahyuni
  • , Hendra Kurniawan
  • , Agus Hendrayana
  • , Poernomo B. Setiawan
  • , Laura N. Yamani
  • , S. Soetjipto
  • , Yoshihiko Yano
  • , Hak Hotta
  • , Yoshitake Hayashi
  • , Maria I. Lusida*
  • *Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

This study demonstrated that Indonesian patients with chronic hepatitis C (mostly ethnic Java people) mostly were infected with hepatitis C virus (HCV) genotype 1; however, they carried mainly the major genotypes of interleukin 28B (IL-28B) single nucleotide polymorphisms (SNPs) (rs12979860 CC, rs11881222 TT, rs8103142 AA, and rs8099917 TT), and they mostly achieved sustained virological responses to pegylated interferon/ribavirin treatment.

Original languageEnglish
Pages (from-to)2193-2195
Number of pages3
JournalJournal of Clinical Microbiology
Volume52
Issue number6
DOIs
Publication statusPublished - Jun 2014
Externally publishedYes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

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