Garcinia mangostana extract enhances skin epithelialization in rat induced burn injury

Mangosteen has several important elements for biological activities such as anti-oxidant, anti-inflammatory, anti-bacterial and anti-cancer. There are γ-mangostin, α-mangostin, flavonoids, saponins, and tannins which could stimulate the collagen deposition and accelerate wound healing process. Burn injury cause deep wound in the skin and often cause cicatrix and keloid scar on the skin. However, there is limited information about role of mangosteen in skin wound healing after burn injury. Fifty 10 week-old male rats, were subjected to burn injury using automatic temperature control. Burn injury was created by direct contact of hot plate (170°C) for 15 seconds on rats' inter scapula region. We elaborated the role of extract mangosteen in skin wound healing by applying daily gel contain with active compound derived from mangosteen. There was no significant weight change during treatment period. We observed that there was significant increase of Epidermal Growth Factors (EGF) expression in 14 as shown in immunohistochemistry and confirmed by western blot protein results. Taken together, mangosteen peel extract-mediated changes in the expression of growth factors in burned rat skins. Mangosteen peel extract might have a role in the acceleration of skin wound healing.