Fortification of skim milk with whey protein xanthone and its effect on antihyperglycemic activities in animal model

Diabetes Mellitus (DM) is a disease characterized by the increase of blood sugar levels, due to the damage of insulin-producing cells in the pancreas. DM management includes taking glucose-lowering bioactive compounds from natural products such as xanthone and its derivatives from mangosteen peel. Bioactive compounds are susceptible to degradation; therefore, it needs to be protected by whey protein. Whey protein is believed to be a delivery system or carrier in the food system by means of nanocapsules. In addition, fortification of whey protein and xanthone combined into liquid skim milk is a way to diversify dairy products for diabetics. The purpose of this study is to determine the effect of fortification of skim milk with whey protein xanthone on blood glucose levels of hyperglycaemic rats. The results of in vivo study prove that xanthone from mangosteen peel extract and its combination with whey protein nor liquid skim milk significantly affects (α=0.05) the decreased level of blood glucose male Wistar rats.