Enhanced SPR sensor characteristics and performance via TiO₂/CQDs nanocomposite functionalization of D-shaped fiber optic SPR sensor for highly sensitive interleukin-17 detection

Selfi; Dewi Anggraeni; Dionysius J.D.H. Santjojo; Wildan Panji Tresna; Sulaiman Wadi Harun; Masruroh

doi:10.1016/j.talo.2026.100654

Enhanced SPR sensor characteristics and performance via TiO₂/CQDs nanocomposite functionalization of D-shaped fiber optic SPR sensor for highly sensitive interleukin-17 detection

Selfi
, Dewi Anggraeni
, Dionysius J.D.H. Santjojo
, Wildan Panji Tresna
, Sulaiman Wadi Harun
, Masruroh^*

^*Corresponding author for this work

Faculty of Mathematics and Natural Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

High sensitivity is crucial for fiber-optic surface plasmon resonance biosensors. This study presents an enhanced Au-coated SPR sensor functionalized with a TiO₂/Carbon Quantum Dots (CQDs) nanocomposite thin film. The CQDs were sustainably synthesized from sugarcane bagasse using an eco-friendly hydrothermal method. By employing Ultrasonic Spray Pyrolysis, the TiO₂/CQDs nanocomposite optimizes both the plasmonic layer and the evanescent-field distribution. Sensor performance for the human IL-17 isolate showed significant improvements: sensitivity increased significantly from 2947.49 nm/RIU (single Au) to 4244.38 nm/RIU Au–TiO₂/CQDs, achieving a Figure of Merit (FOM) of 38.75 RIU⁻¹. This environmentally friendly approach promises highly sensitive SPR sensor development.

Original language	English
Article number	100654
Journal	Talanta Open
Volume	13
DOIs	https://doi.org/10.1016/j.talo.2026.100654
Publication status	Published - Aug 2026

Keywords

Human IL-17 isolate
Sugarcane bagasse
TiO/CQDs nanocomposite

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10.1016/j.talo.2026.100654

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title = "Enhanced SPR sensor characteristics and performance via TiO₂/CQDs nanocomposite functionalization of D-shaped fiber optic SPR sensor for highly sensitive interleukin-17 detection",

abstract = "High sensitivity is crucial for fiber-optic surface plasmon resonance biosensors. This study presents an enhanced Au-coated SPR sensor functionalized with a TiO₂/Carbon Quantum Dots (CQDs) nanocomposite thin film. The CQDs were sustainably synthesized from sugarcane bagasse using an eco-friendly hydrothermal method. By employing Ultrasonic Spray Pyrolysis, the TiO₂/CQDs nanocomposite optimizes both the plasmonic layer and the evanescent-field distribution. Sensor performance for the human IL-17 isolate showed significant improvements: sensitivity increased significantly from 2947.49 nm/RIU (single Au) to 4244.38 nm/RIU Au{\textendash}TiO₂/CQDs, achieving a Figure of Merit (FOM) of 38.75 RIU⁻¹. This environmentally friendly approach promises highly sensitive SPR sensor development.",

keywords = "Human IL-17 isolate, Sugarcane bagasse, TiO/CQDs nanocomposite",

author = "Selfi and Dewi Anggraeni and Santjojo, \{Dionysius J.D.H.\} and Tresna, \{Wildan Panji\} and Harun, \{Sulaiman Wadi\} and Masruroh",

note = "Publisher Copyright: {\textcopyright} 2026 The Author(s).",

year = "2026",

month = aug,

doi = "10.1016/j.talo.2026.100654",

language = "English",

volume = "13",

journal = "Talanta Open",

issn = "2666-8319",

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T1 - Enhanced SPR sensor characteristics and performance via TiO₂/CQDs nanocomposite functionalization of D-shaped fiber optic SPR sensor for highly sensitive interleukin-17 detection

AU - Selfi,

AU - Anggraeni, Dewi

AU - Santjojo, Dionysius J.D.H.

AU - Tresna, Wildan Panji

AU - Harun, Sulaiman Wadi

AU - Masruroh,

PY - 2026/8

Y1 - 2026/8

N2 - High sensitivity is crucial for fiber-optic surface plasmon resonance biosensors. This study presents an enhanced Au-coated SPR sensor functionalized with a TiO₂/Carbon Quantum Dots (CQDs) nanocomposite thin film. The CQDs were sustainably synthesized from sugarcane bagasse using an eco-friendly hydrothermal method. By employing Ultrasonic Spray Pyrolysis, the TiO₂/CQDs nanocomposite optimizes both the plasmonic layer and the evanescent-field distribution. Sensor performance for the human IL-17 isolate showed significant improvements: sensitivity increased significantly from 2947.49 nm/RIU (single Au) to 4244.38 nm/RIU Au–TiO₂/CQDs, achieving a Figure of Merit (FOM) of 38.75 RIU⁻¹. This environmentally friendly approach promises highly sensitive SPR sensor development.

AB - High sensitivity is crucial for fiber-optic surface plasmon resonance biosensors. This study presents an enhanced Au-coated SPR sensor functionalized with a TiO₂/Carbon Quantum Dots (CQDs) nanocomposite thin film. The CQDs were sustainably synthesized from sugarcane bagasse using an eco-friendly hydrothermal method. By employing Ultrasonic Spray Pyrolysis, the TiO₂/CQDs nanocomposite optimizes both the plasmonic layer and the evanescent-field distribution. Sensor performance for the human IL-17 isolate showed significant improvements: sensitivity increased significantly from 2947.49 nm/RIU (single Au) to 4244.38 nm/RIU Au–TiO₂/CQDs, achieving a Figure of Merit (FOM) of 38.75 RIU⁻¹. This environmentally friendly approach promises highly sensitive SPR sensor development.

KW - Human IL-17 isolate

KW - Sugarcane bagasse

KW - TiO/CQDs nanocomposite

UR - https://www.scopus.com/pages/publications/105038346122

U2 - 10.1016/j.talo.2026.100654

DO - 10.1016/j.talo.2026.100654

M3 - Article

AN - SCOPUS:105038346122

SN - 2666-8319

VL - 13

JO - Talanta Open

JF - Talanta Open

M1 - 100654

ER -

Enhanced SPR sensor characteristics and performance via TiO₂/CQDs nanocomposite functionalization of D-shaped fiber optic SPR sensor for highly sensitive interleukin-17 detection

Abstract

Keywords

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