Effects of subchronic exposure of PSP Ganoderma lucidum on renal function and histopathology feature in Rattus novergicus Wistar strain

Background: Ganoderma lucidum, commonly referred to as Lingzhi in China, is a fungus that has been widely used through the centuries for the general promotion of health and longevity in Asian countries. Aims and Objective: To determine the effects of subchronic exposure of PSP G. lucidum on renal function and renal histopathology feature in Rattus novergicus Wistar strain. Materials and Methods: A total of 80 male and female Wistar rats, aged 2–3 months with a body weight of 200–300 g, were divided into four treatment groups: dose group 0 (control group), group PSP G. lucidum dose of 300, 600, and 1200 mg/kg for 90 days. Parameters measured were urea and creatinine levels and renal histopathology feature. Result: From the research, the highest urea levels were found in the group in which female Wistar rats were treated with PSP dose of 300 mg/kg/day with an average concentration of urea of 33.2 mg/dL, whereas creatinine levels were found to be equally high on treatment with PSP dose of 1200, 600, and 300 mg/kg/day with an average concentration of urea of 0.3 mg/dL. On histopathological examination, no morphological abnormalities were found. The results of one-way analysis of variance test showed no significant difference at all PSP G. lucidum doses. Conclusion: It is concluded that giving PSP G. lucidum in three variant doses does not cause dysfunction and histological damage to the renal function.