Effect of Sargassum echinocarpum extract on Cu-Zn superoxide dismutase expression in liver and kidney of diabetic rats

Muhamad Firdaus; Made Astawan; Tutik Wresdiyati

doi:10.1063/1.5115735

Effect of Sargassum echinocarpum extract on Cu-Zn superoxide dismutase expression in liver and kidney of diabetic rats

Muhamad Firdaus^*
, Made Astawan
, Tutik Wresdiyati

^*Corresponding author for this work

Faculty of Fisheries and Marine Sciences

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

1 Citation (Scopus)

Abstract

Hyperglycemic can increase the level of free radicals and reduce the activity of antioxidant enzymes. Sargassum echinocarpum is one of the brown seaweeds which contains bioactive compounds with hypoglycemic and free radical scavenging activities. This study aimed to evaluate the administration of S. echinocarpum extract (SEE) on the expression of Cu, Zn-Superoxide dismutase in liver and kidney of diabetic rats. S. echinocarpum was obtained from Talango waters, Sumenep District. Male rats Sprague-Dawley strain weighing 125-150 g were used in this study. Streptozotocin was used as a hyperglycemic inducer. This research was designed to five groups: normal, diabetic, diabetic + 150 mg/kg of SEE, diabetic + 300 mg/kg of SEE, and diabetic + 450 mg/kg of SEE, respectively, and all of the groups were treated for 90 days. The expression of Cu, Zn-Superoxide was observed by immunohistochemistry method. The results showed that 450 mg/kg of SEE is the strongest doses to decrease the blood glucose level and preserve the expression of Cu, Zn-Superoxide dismutase in the liver and kidney of diabetic rats. In conclusion administration of 450 mg/kg of SEE able to decrease the blood glucose level and reserve the Cu, Zn-Superoxide dismutase and this substance can be generated as an anti-stress oxidative agent on diabetes.

Original language	English
Title of host publication	International Conference on Biology and Applied Science, ICOBAS 2019
Editors	Romaidi, Didik Wahyudi, Retno Novvitasari Hery Daryono, Eriyanto Yusnawan, Akira Kikuchi
Publisher	American Institute of Physics Inc.
ISBN (Electronic)	9780735418608
DOIs	https://doi.org/10.1063/1.5115735
Publication status	Published - 3 Jul 2019
Event	International Conference on Biology and Applied Science 2019, ICOBAS 2019 - Malang, Indonesia Duration: 13 Mar 2019 → 14 Mar 2019

Publication series

Name	AIP Conference Proceedings
Volume	2120
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	International Conference on Biology and Applied Science 2019, ICOBAS 2019
Country/Territory	Indonesia
City	Malang
Period	13/03/19 → 14/03/19

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1063/1.5115735

Cite this

Firdaus, M., Astawan, M., & Wresdiyati, T. (2019). Effect of Sargassum echinocarpum extract on Cu-Zn superoxide dismutase expression in liver and kidney of diabetic rats. In Romaidi, D. Wahyudi, R. N. H. Daryono, E. Yusnawan, & A. Kikuchi (Eds.), International Conference on Biology and Applied Science, ICOBAS 2019 Article 070018 (AIP Conference Proceedings; Vol. 2120). American Institute of Physics Inc.. https://doi.org/10.1063/1.5115735

Firdaus, Muhamad ; Astawan, Made ; Wresdiyati, Tutik. / Effect of Sargassum echinocarpum extract on Cu-Zn superoxide dismutase expression in liver and kidney of diabetic rats. International Conference on Biology and Applied Science, ICOBAS 2019. editor / Romaidi ; Didik Wahyudi ; Retno Novvitasari Hery Daryono ; Eriyanto Yusnawan ; Akira Kikuchi. American Institute of Physics Inc., 2019. (AIP Conference Proceedings).

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title = "Effect of Sargassum echinocarpum extract on Cu-Zn superoxide dismutase expression in liver and kidney of diabetic rats",

abstract = "Hyperglycemic can increase the level of free radicals and reduce the activity of antioxidant enzymes. Sargassum echinocarpum is one of the brown seaweeds which contains bioactive compounds with hypoglycemic and free radical scavenging activities. This study aimed to evaluate the administration of S. echinocarpum extract (SEE) on the expression of Cu, Zn-Superoxide dismutase in liver and kidney of diabetic rats. S. echinocarpum was obtained from Talango waters, Sumenep District. Male rats Sprague-Dawley strain weighing 125-150 g were used in this study. Streptozotocin was used as a hyperglycemic inducer. This research was designed to five groups: normal, diabetic, diabetic + 150 mg/kg of SEE, diabetic + 300 mg/kg of SEE, and diabetic + 450 mg/kg of SEE, respectively, and all of the groups were treated for 90 days. The expression of Cu, Zn-Superoxide was observed by immunohistochemistry method. The results showed that 450 mg/kg of SEE is the strongest doses to decrease the blood glucose level and preserve the expression of Cu, Zn-Superoxide dismutase in the liver and kidney of diabetic rats. In conclusion administration of 450 mg/kg of SEE able to decrease the blood glucose level and reserve the Cu, Zn-Superoxide dismutase and this substance can be generated as an anti-stress oxidative agent on diabetes.",

author = "Muhamad Firdaus and Made Astawan and Tutik Wresdiyati",

note = "Publisher Copyright: {\textcopyright} 2019 Author(s).; International Conference on Biology and Applied Science 2019, ICOBAS 2019 ; Conference date: 13-03-2019 Through 14-03-2019",

year = "2019",

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doi = "10.1063/1.5115735",

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Firdaus, M, Astawan, M & Wresdiyati, T 2019, Effect of Sargassum echinocarpum extract on Cu-Zn superoxide dismutase expression in liver and kidney of diabetic rats. in Romaidi, D Wahyudi, RNH Daryono, E Yusnawan & A Kikuchi (eds), International Conference on Biology and Applied Science, ICOBAS 2019., 070018, AIP Conference Proceedings, vol. 2120, American Institute of Physics Inc., International Conference on Biology and Applied Science 2019, ICOBAS 2019, Malang, Indonesia, 13/03/19. https://doi.org/10.1063/1.5115735

Effect of Sargassum echinocarpum extract on Cu-Zn superoxide dismutase expression in liver and kidney of diabetic rats. / Firdaus, Muhamad; Astawan, Made; Wresdiyati, Tutik.
International Conference on Biology and Applied Science, ICOBAS 2019. ed. / Romaidi; Didik Wahyudi; Retno Novvitasari Hery Daryono; Eriyanto Yusnawan; Akira Kikuchi. American Institute of Physics Inc., 2019. 070018 (AIP Conference Proceedings; Vol. 2120).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Effect of Sargassum echinocarpum extract on Cu-Zn superoxide dismutase expression in liver and kidney of diabetic rats

AU - Firdaus, Muhamad

AU - Astawan, Made

AU - Wresdiyati, Tutik

PY - 2019/7/3

Y1 - 2019/7/3

N2 - Hyperglycemic can increase the level of free radicals and reduce the activity of antioxidant enzymes. Sargassum echinocarpum is one of the brown seaweeds which contains bioactive compounds with hypoglycemic and free radical scavenging activities. This study aimed to evaluate the administration of S. echinocarpum extract (SEE) on the expression of Cu, Zn-Superoxide dismutase in liver and kidney of diabetic rats. S. echinocarpum was obtained from Talango waters, Sumenep District. Male rats Sprague-Dawley strain weighing 125-150 g were used in this study. Streptozotocin was used as a hyperglycemic inducer. This research was designed to five groups: normal, diabetic, diabetic + 150 mg/kg of SEE, diabetic + 300 mg/kg of SEE, and diabetic + 450 mg/kg of SEE, respectively, and all of the groups were treated for 90 days. The expression of Cu, Zn-Superoxide was observed by immunohistochemistry method. The results showed that 450 mg/kg of SEE is the strongest doses to decrease the blood glucose level and preserve the expression of Cu, Zn-Superoxide dismutase in the liver and kidney of diabetic rats. In conclusion administration of 450 mg/kg of SEE able to decrease the blood glucose level and reserve the Cu, Zn-Superoxide dismutase and this substance can be generated as an anti-stress oxidative agent on diabetes.

AB - Hyperglycemic can increase the level of free radicals and reduce the activity of antioxidant enzymes. Sargassum echinocarpum is one of the brown seaweeds which contains bioactive compounds with hypoglycemic and free radical scavenging activities. This study aimed to evaluate the administration of S. echinocarpum extract (SEE) on the expression of Cu, Zn-Superoxide dismutase in liver and kidney of diabetic rats. S. echinocarpum was obtained from Talango waters, Sumenep District. Male rats Sprague-Dawley strain weighing 125-150 g were used in this study. Streptozotocin was used as a hyperglycemic inducer. This research was designed to five groups: normal, diabetic, diabetic + 150 mg/kg of SEE, diabetic + 300 mg/kg of SEE, and diabetic + 450 mg/kg of SEE, respectively, and all of the groups were treated for 90 days. The expression of Cu, Zn-Superoxide was observed by immunohistochemistry method. The results showed that 450 mg/kg of SEE is the strongest doses to decrease the blood glucose level and preserve the expression of Cu, Zn-Superoxide dismutase in the liver and kidney of diabetic rats. In conclusion administration of 450 mg/kg of SEE able to decrease the blood glucose level and reserve the Cu, Zn-Superoxide dismutase and this substance can be generated as an anti-stress oxidative agent on diabetes.

UR - https://www.scopus.com/pages/publications/85068747301

U2 - 10.1063/1.5115735

DO - 10.1063/1.5115735

M3 - Conference contribution

AN - SCOPUS:85068747301

T3 - AIP Conference Proceedings

BT - International Conference on Biology and Applied Science, ICOBAS 2019

A2 - Romaidi, null

A2 - Wahyudi, Didik

A2 - Daryono, Retno Novvitasari Hery

A2 - Yusnawan, Eriyanto

A2 - Kikuchi, Akira

PB - American Institute of Physics Inc.

T2 - International Conference on Biology and Applied Science 2019, ICOBAS 2019

Y2 - 13 March 2019 through 14 March 2019

ER -

Firdaus M, Astawan M, Wresdiyati T. Effect of Sargassum echinocarpum extract on Cu-Zn superoxide dismutase expression in liver and kidney of diabetic rats. In Romaidi, Wahyudi D, Daryono RNH, Yusnawan E, Kikuchi A, editors, International Conference on Biology and Applied Science, ICOBAS 2019. American Institute of Physics Inc. 2019. 070018. (AIP Conference Proceedings). doi: 10.1063/1.5115735

Effect of Sargassum echinocarpum extract on Cu-Zn superoxide dismutase expression in liver and kidney of diabetic rats

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