Effect of physalis minima l. On interferon-g and interleukin1β levels in 7,12-dimethylbenz[a]anthracene administered mice

Introduction: 7.12-Dimethylbenz[a]anthracene (DMBA) is a carcinogenic substance that can have immunosuppressive effects. Physalis minima L. is one of the herbal medicinal substances that was assumed to modulate immunosuppressive effects in DMBA-induced mice toward interferon γ (IFN-γ) and interleukin-1β (IL-1β). Materials and Methods: Female BALB/c mice were given DMBA. DMBA-induced mice were administered with Physalis extract, once a day for two weeks. The level of IFN-γ and IL-1β were measured using a flow cytometer. Results: Physalis minima L. extract was able to increase (p<0.05) the level of IFN-γ in DMBA-given groups. Meanwhile, Physalis minima L. extract could increase the level of IL-1β in group C+D1 (p<0,05). Conclusions: Physalis minima L. extract could increase the level of IFN-γ and IL-1β in DMBA Induced Mice.