Effect of nanocurcumin administration on superoxide dismutase and progesterone level exposure to noise stress during pregnancy in mice

Background: Continuous noise with high decibels (dB) intensity continuously can cause psychological stress in a person. Stress during pregnancy can have a negative impact on fetal development; this is due to the narrowing of the placental artery and ends in the obstruction of the flow of nutrients and oxygen to the fetus. Increased cortisol levels during pregnancy stress will signal the placenta to reduce the production of progesterone and estradiol and stimulate the secretion of prostaglandins that activate contractions. Aim: This study aims to determine the effect of nanocurcumin administration on pregnant mice under the stress of 135 dB disturbance for 40 minutes with a continuous pattern. Methods: This experimental study used 25 female mice in five groups: K(−) with no treatment, K(+) with 135 dB disturbance induction for 40 minutes with a continuous pattern, P1 given disturbance and nanocurcumin dose 14 mg/ kgBW, P2 given disturbance and nanocurcumin dose 21 mg/kgBW, and P3 given disturbance and nanocurcumin 24.5 mg/kgBW. SOD and progesterone were tested using ELISA. Result: Data analysis using one-way ANOVA followed by the least significant difference. The result of this study conducted nanocurcumin dose of 24.5 mg/kgBW gave the most significant effect (P < 0.05) in reducing SOD levels and restoring progesterone levels in mice that had disorders during pregnancy compared with doses of 14 and 21 mg/ kgBW, respectively. Conclusion: The conclusion of this study, an administration of nanocurcumin at a dose of 24.5 mg/kgBW, was effective in reducing oxidative stress and increasing progesterone levels in mice that experienced stress due to disorders during pregnancy.