Determining the effect of benzo[a]pyrene exposures toward innate and adaptive immunity profiles in post-measles vaccination mouse model

Measles is an infectious disease caused by a virus of the genus Morbillivirus and is considered as global health problem. Several causes have been postulated that affect the success rate of vaccination, including benzo[a]pyrene exposure which widely distributed in air pollution. This study aims to evaluate the effect of BaP exposure to mouse immunity after measles vaccination. Several immunological parameters observed in this study were the expression of CD4⁺TNF-α⁺, CD4⁺IFN-γ⁺, CD4⁺IFN-α⁺, CD8⁺IFN-α⁺, CD11b⁺IL17⁺, B220⁺CD25⁺, and the ratio of CD4⁺:B220⁺ from benzo[a]pyrene-exposured BALB/c mouse post-measles vaccination. Each sample was analyzed using a flow cytometry analysis. According to our findings, we found that benzo[a] pyrene interferes several parameters of immune system in measles-vaccinated mice. These findings suggested that the pollutant compounds especially benzo[a]pyrene can suppress the success rate of vaccination.