Determination Factors Associated with Immune Responses Towards First Dose Edmonston-Zagreb (EZ) Measles Vaccine in Indonesian Infants

Background: Measles outbreaks under high coverage of measles vaccination in Indonesia is gaining a necessary evaluation of factors associated with measles-vaccine immune responses. Objctive: The purposes of recent study were to evaluate the association of so-ciodemographic and anthropometric parameters and specific immune responses towards first dose Edmonston-Zagreb (EZ) measles vaccine in Indonesian infants. Methods: A total of 35 infants were enrolled in this cohort study. Measles immune responses were followed up at one and six months after vaccination then analyzed for its association with sociode-mographic, anthropometric, and nutritional parameters. The plaque-reduction microneu-tralization assay was conducted to measure the titer of measles specific IgG antibody. The level of CD4⁺ and CD8⁺ T-cells that exhibiting gamma interferon (IFN-γ) secretion were analyzed by flow cytometry. The association between variable was analyzed by linear regres-sion. The difference immune response among variable were analyzed with Mann-Whitney test. Results: Vitamin A supplementation and breastfeeding were predicted as associated factor for humoral and cellular immune response after one month and six months measles vaccination among Indonesia Infants. Conclusion: Nutritional factor is associated with measles vaccination immune response in Indonesian infants.