Curcuma zedoaria: Potential effect as breast cancer chemotherapeutic agents through CXCR4 inhibition

Nur Fitriana; Muhaimin Rifa'i

doi:10.1063/5.0002629

Curcuma zedoaria: Potential effect as breast cancer chemotherapeutic agents through CXCR4 inhibition

Nur Fitriana
, Muhaimin Rifa'i
, Widodo^*

^*Corresponding author for this work

Faculty of Mathematics and Natural Sciences

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

5 Citations (Scopus)

Abstract

Current breast cancer treatment has shifted to using natural ingredients such as C. zedoaria high potential and low side effects. Previous studies show that C. zedoaria active compounds used as anti-proliferative, increasing apoptosis, and anti-metastasis. However, information about the mechanism of the active compound to inhibition of CXCR4 in the carcinogenesis process unknown. CXCR4 is a specific receptor for CXCL12 and known to play an essential role in prognosis and drug target of breast cancer. This research aimed to analyze the effect of C. zedoaria active compounds as breast cancer chemotherapeutic agents through CXCR4 inhibition. Binding affinity value shows that 11 compounds from C. zedoaria have the potential to inhibit CXCR4 with the smallest binding affinity and the same binding site with Chalcone and Epirubicin. However, Stigmasterol, Campesterol, and β-sitosterol have the lowest binding affinity than the other active compound. Analysis of protein interaction shows that CXCR4 interacts with CXCL12, STAT3, and JAK2. Its protein used as a poor prognosis factor for cancer. These results indicate that C. zedoaria are active compounds and are highly potential as anti-breast cancer. Further research is needed to validate the above data.

Original language	English
Title of host publication	International Conference on Life Science and Technology, ICoLiST 2019
Editors	Ahmad Taufiq, Hendra Susanto, Hadi Nur, Muhammad Aziz, Chuang-Rung Chang, Hyohyemi Lee, Markus Diantoro, Nandang Mufti, Nik Ahmad Nizam Nik Malek, I. Ching Wang, Djoko Tjahnono Iskandar, Gereon Elbers, Sunaryono Sunaryono, Siti Zubaidah, Sumari Sumari, Aulanni'am, Asep Bayu Nandiyanto, Indra Wibowo, Adeodatus Yuda Handaya
Publisher	American Institute of Physics Inc.
ISBN (Electronic)	9780735419902
DOIs	https://doi.org/10.1063/5.0002629
Publication status	Published - 21 Apr 2020
Event	2nd International Conference on Life Science and Technology, ICoLiST 2019 - Malang, East Java, Indonesia Duration: 12 Sept 2019 → 13 Sept 2019

Publication series

Name	AIP Conference Proceedings
Volume	2231
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	2nd International Conference on Life Science and Technology, ICoLiST 2019
Country/Territory	Indonesia
City	Malang, East Java
Period	12/09/19 → 13/09/19

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1063/5.0002629

Cite this

Fitriana, N., Rifa'i, M., & Widodo (2020). Curcuma zedoaria: Potential effect as breast cancer chemotherapeutic agents through CXCR4 inhibition. In A. Taufiq, H. Susanto, H. Nur, M. Aziz, C.-R. Chang, H. Lee, M. Diantoro, N. Mufti, N. A. N. N. Malek, I. C. Wang, D. T. Iskandar, G. Elbers, S. Sunaryono, S. Zubaidah, S. Sumari, Aulanni'am, A. B. Nandiyanto, I. Wibowo, & A. Y. Handaya (Eds.), International Conference on Life Science and Technology, ICoLiST 2019 Article 2629 (AIP Conference Proceedings; Vol. 2231). American Institute of Physics Inc.. https://doi.org/10.1063/5.0002629

Fitriana, Nur ; Rifa'i, Muhaimin ; Widodo. / Curcuma zedoaria : Potential effect as breast cancer chemotherapeutic agents through CXCR4 inhibition. International Conference on Life Science and Technology, ICoLiST 2019. editor / Ahmad Taufiq ; Hendra Susanto ; Hadi Nur ; Muhammad Aziz ; Chuang-Rung Chang ; Hyohyemi Lee ; Markus Diantoro ; Nandang Mufti ; Nik Ahmad Nizam Nik Malek ; I. Ching Wang ; Djoko Tjahnono Iskandar ; Gereon Elbers ; Sunaryono Sunaryono ; Siti Zubaidah ; Sumari Sumari ; Aulanni'am ; Asep Bayu Nandiyanto ; Indra Wibowo ; Adeodatus Yuda Handaya. American Institute of Physics Inc., 2020. (AIP Conference Proceedings).

@inproceedings{50ae0ab4779d459f86a0778b9fad687e,

title = "Curcuma zedoaria: Potential effect as breast cancer chemotherapeutic agents through CXCR4 inhibition",

abstract = "Current breast cancer treatment has shifted to using natural ingredients such as C. zedoaria high potential and low side effects. Previous studies show that C. zedoaria active compounds used as anti-proliferative, increasing apoptosis, and anti-metastasis. However, information about the mechanism of the active compound to inhibition of CXCR4 in the carcinogenesis process unknown. CXCR4 is a specific receptor for CXCL12 and known to play an essential role in prognosis and drug target of breast cancer. This research aimed to analyze the effect of C. zedoaria active compounds as breast cancer chemotherapeutic agents through CXCR4 inhibition. Binding affinity value shows that 11 compounds from C. zedoaria have the potential to inhibit CXCR4 with the smallest binding affinity and the same binding site with Chalcone and Epirubicin. However, Stigmasterol, Campesterol, and β-sitosterol have the lowest binding affinity than the other active compound. Analysis of protein interaction shows that CXCR4 interacts with CXCL12, STAT3, and JAK2. Its protein used as a poor prognosis factor for cancer. These results indicate that C. zedoaria are active compounds and are highly potential as anti-breast cancer. Further research is needed to validate the above data.",

author = "Nur Fitriana and Muhaimin Rifa'i and Widodo",

note = "Publisher Copyright: {\textcopyright} 2020 American Institute of Physics Inc.. All rights reserved.; 2nd International Conference on Life Science and Technology, ICoLiST 2019 ; Conference date: 12-09-2019 Through 13-09-2019",

year = "2020",

month = apr,

day = "21",

doi = "10.1063/5.0002629",

language = "English",

series = "AIP Conference Proceedings",

publisher = "American Institute of Physics Inc.",

editor = "Ahmad Taufiq and Hendra Susanto and Hadi Nur and Muhammad Aziz and Chuang-Rung Chang and Hyohyemi Lee and Markus Diantoro and Nandang Mufti and Malek, \{Nik Ahmad Nizam Nik\} and Wang, \{I. Ching\} and Iskandar, \{Djoko Tjahnono\} and Gereon Elbers and Sunaryono Sunaryono and Siti Zubaidah and Sumari Sumari and Aulanni'am and Nandiyanto, \{Asep Bayu\} and Indra Wibowo and Handaya, \{Adeodatus Yuda\}",

booktitle = "International Conference on Life Science and Technology, ICoLiST 2019",

}

Fitriana, N, Rifa'i, M & Widodo 2020, Curcuma zedoaria: Potential effect as breast cancer chemotherapeutic agents through CXCR4 inhibition. in A Taufiq, H Susanto, H Nur, M Aziz, C-R Chang, H Lee, M Diantoro, N Mufti, NANN Malek, IC Wang, DT Iskandar, G Elbers, S Sunaryono, S Zubaidah, S Sumari, Aulanni'am, AB Nandiyanto, I Wibowo & AY Handaya (eds), International Conference on Life Science and Technology, ICoLiST 2019., 2629, AIP Conference Proceedings, vol. 2231, American Institute of Physics Inc., 2nd International Conference on Life Science and Technology, ICoLiST 2019, Malang, East Java, Indonesia, 12/09/19. https://doi.org/10.1063/5.0002629

Curcuma zedoaria: Potential effect as breast cancer chemotherapeutic agents through CXCR4 inhibition. / Fitriana, Nur; Rifa'i, Muhaimin ; Widodo.
International Conference on Life Science and Technology, ICoLiST 2019. ed. / Ahmad Taufiq; Hendra Susanto; Hadi Nur; Muhammad Aziz; Chuang-Rung Chang; Hyohyemi Lee; Markus Diantoro; Nandang Mufti; Nik Ahmad Nizam Nik Malek; I. Ching Wang; Djoko Tjahnono Iskandar; Gereon Elbers; Sunaryono Sunaryono; Siti Zubaidah; Sumari Sumari; Aulanni'am; Asep Bayu Nandiyanto; Indra Wibowo; Adeodatus Yuda Handaya. American Institute of Physics Inc., 2020. 2629 (AIP Conference Proceedings; Vol. 2231).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Curcuma zedoaria

T2 - 2nd International Conference on Life Science and Technology, ICoLiST 2019

AU - Fitriana, Nur

AU - Rifa'i, Muhaimin

AU - Widodo,

PY - 2020/4/21

Y1 - 2020/4/21

N2 - Current breast cancer treatment has shifted to using natural ingredients such as C. zedoaria high potential and low side effects. Previous studies show that C. zedoaria active compounds used as anti-proliferative, increasing apoptosis, and anti-metastasis. However, information about the mechanism of the active compound to inhibition of CXCR4 in the carcinogenesis process unknown. CXCR4 is a specific receptor for CXCL12 and known to play an essential role in prognosis and drug target of breast cancer. This research aimed to analyze the effect of C. zedoaria active compounds as breast cancer chemotherapeutic agents through CXCR4 inhibition. Binding affinity value shows that 11 compounds from C. zedoaria have the potential to inhibit CXCR4 with the smallest binding affinity and the same binding site with Chalcone and Epirubicin. However, Stigmasterol, Campesterol, and β-sitosterol have the lowest binding affinity than the other active compound. Analysis of protein interaction shows that CXCR4 interacts with CXCL12, STAT3, and JAK2. Its protein used as a poor prognosis factor for cancer. These results indicate that C. zedoaria are active compounds and are highly potential as anti-breast cancer. Further research is needed to validate the above data.

AB - Current breast cancer treatment has shifted to using natural ingredients such as C. zedoaria high potential and low side effects. Previous studies show that C. zedoaria active compounds used as anti-proliferative, increasing apoptosis, and anti-metastasis. However, information about the mechanism of the active compound to inhibition of CXCR4 in the carcinogenesis process unknown. CXCR4 is a specific receptor for CXCL12 and known to play an essential role in prognosis and drug target of breast cancer. This research aimed to analyze the effect of C. zedoaria active compounds as breast cancer chemotherapeutic agents through CXCR4 inhibition. Binding affinity value shows that 11 compounds from C. zedoaria have the potential to inhibit CXCR4 with the smallest binding affinity and the same binding site with Chalcone and Epirubicin. However, Stigmasterol, Campesterol, and β-sitosterol have the lowest binding affinity than the other active compound. Analysis of protein interaction shows that CXCR4 interacts with CXCL12, STAT3, and JAK2. Its protein used as a poor prognosis factor for cancer. These results indicate that C. zedoaria are active compounds and are highly potential as anti-breast cancer. Further research is needed to validate the above data.

UR - https://www.scopus.com/pages/publications/85092589924

U2 - 10.1063/5.0002629

DO - 10.1063/5.0002629

M3 - Conference contribution

AN - SCOPUS:85092589924

T3 - AIP Conference Proceedings

BT - International Conference on Life Science and Technology, ICoLiST 2019

A2 - Taufiq, Ahmad

A2 - Susanto, Hendra

A2 - Nur, Hadi

A2 - Aziz, Muhammad

A2 - Chang, Chuang-Rung

A2 - Lee, Hyohyemi

A2 - Diantoro, Markus

A2 - Mufti, Nandang

A2 - Malek, Nik Ahmad Nizam Nik

A2 - Wang, I. Ching

A2 - Iskandar, Djoko Tjahnono

A2 - Elbers, Gereon

A2 - Sunaryono, Sunaryono

A2 - Zubaidah, Siti

A2 - Sumari, Sumari

A2 - Aulanni'am, null

A2 - Nandiyanto, Asep Bayu

A2 - Wibowo, Indra

A2 - Handaya, Adeodatus Yuda

PB - American Institute of Physics Inc.

Y2 - 12 September 2019 through 13 September 2019

ER -

Fitriana N, Rifa'i M , Widodo. Curcuma zedoaria: Potential effect as breast cancer chemotherapeutic agents through CXCR4 inhibition. In Taufiq A, Susanto H, Nur H, Aziz M, Chang CR, Lee H, Diantoro M, Mufti N, Malek NANN, Wang IC, Iskandar DT, Elbers G, Sunaryono S, Zubaidah S, Sumari S, Aulanni'am, Nandiyanto AB, Wibowo I, Handaya AY, editors, International Conference on Life Science and Technology, ICoLiST 2019. American Institute of Physics Inc. 2020. 2629. (AIP Conference Proceedings). doi: 10.1063/5.0002629

Curcuma zedoaria: Potential effect as breast cancer chemotherapeutic agents through CXCR4 inhibition

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