Correlation of Oxidized-Low Density Lipoprotein (ox-LDL), Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL) with Framingham Risk Score (FRS) of Coronary Heart Disease (CHD)

Coronary Heart Disease (CHD) is the leading cause of death worldwide. CHD preceded by the atherosclerosis process. Ox-LDL, LDL, and HDL cholesterol may be more potent biomarkers for predicting and diagnosing CHD than those only conventional measurements of lipid levels with the Framingham Risk Score (FRS). Purpose to determine the correlation between Ox-LDL, LDL, HDL levels and FRS in a population at risk of CHD This study was an analytical descriptive with a cross-sectional research design. The research subjects were 143 (79 male and 64 female) subjects. Serum Ox-LDL, LDL, HDL levels were checked by Sandwich ELISA method. FRS includes gender, age, total cholesterol, HDL-cholesterol, systolic blood pressure, history of taking antihypertensive drugs, smoking, diabetes, and vascular disease (CHD, Stroke). Ox-LDL and HDL levels had a very weak negative correlation to FRS (p = 0.017; r = -0.199; p = 0.000; r = -0.305) and had a very weak effect (R=0.174, R2=3%; R= 0.283, R2=8%). Levels of LDL and FRS were not correlated (p = 0.558; r = -0.049) and had no effect (R=0.007, R2=0%). Ox-LDL, HDL, and FRS levels were negatively correlated, meanwhile the LDL and FRS has no correlation. Besides, they all had a weak effect to FRS. The discrepancy of Ox-LDL, LDL, HDL and FRS levels is due to the limitations of FRS, which neglects other non-conventional CHD risk factors. Also, race differences may cause FRS might be unsuitable for Asian.