Correlation between ldl, hdl, ldl/hdl ratio and preeclampsia incidence at rsud pamekasan, indonesia

Besides bleeding and infection, preeclampsia is the leading cause of maternal mortality in Indonesia. Preeclampsia may cause multi organ dysfunction which may result in death. Although the exact causes of preeclampsia are not known, one of the widely accepted theories is oxidative stress. Oxidative stress may be triggered by high LDL-c, low HDL-c and high LDL/HDL ratio. The study aimed at investigating the correlation between LDL-c level, HDL-c level, LDL/HDL ratio and preeclampsia incidences at dr. H. Slamet Martodirdjo Regional General Hospital (RSUD) Pamekasan. The study used analytical observational method and case control design. The subjects were 64 pregnant women consisting of 32 preeclamptic and 32 non-preeclamptic women. The subjects were selected using consecutive sampling method. Data were collected from physical examination and laboratory tests. Data were analyzed using eta and logistic regression test. Result showed that there was a significant correlation at α < 0,05 between LDL level (ρ=0.000), HDL level (ρ=0.000), LDL/HDL ratio (ρ=0.000) and preeclampsia incidence. LDL-c level-c, HDL level, LDL/HDL ratio were risk factors for preeclampsia.. These factors should be targetted by health care professionals when conducting routine prenatal checkups.