Comparison of Neutrophil Eosinophil Ratio (NER) in Chronic Rhinosinusitis with Nasal Polyps (CRSwNP) and Chronic Rhinosinusitis without Nasal Polyps (CRSsNP)

Introduction: Chronic rhinosinusitis is one of the most common world health problems and affects the quality of life. Recent research suggests differences in immunological mechanisms in immunological endotypes between chronic rhinosinusitis with nasal polyps (CRSwNP) and chronic rhinosinusitis without nasal polyps (CRSsNP). Identifying the neutrophil eosinophil ratio (NER) in CRSwNP and CRSsNP is important to determine the type of inflammation so that pathophysiological differences can be known and appropriate therapy can be given. Materials and methods: Cross-sectional study involved 24 subjects. The subjects are divided into two groups based on the phenotype, 12 CRSwNP and 12 CRSsNP. This research uses maxillary sinus mucosa to identify the levels of neutrophils and eosinophils in the maxillary sinus mucosa using flow cytometry. NER in CRSwNP and CRSsNP was analyzed statistically using student t-test. Results: The mean of neutrophils in CRSwNP: 5.31 ± 0.24% (N:1.1–1.7%) and CRSsNP: 4.29 ± 2.42% (N:1.1–1.7%). The mean of eosinophils in CRSwNP: 4.76 ± 2.55% (N: 0.3–0.7%) and CRSsNP 3.60 ± 2.88% (N: 0.3–0.7%). The average NER in CRSwNP was 1.33 ± 0.71 (N:2.8), and CRSsNP was 2.58 ± 3.07 (N:2.8). The results were not significantly different in the two groups (p = 0.196). In CRSwNP and CRSsNP, as many as 83.33% of the subjects had an eosinophilic type of inflammation. Conclusion: There were no significant differences in NER and type of inflammation between chronic rhinosinusitis with polyps and without polyps.