TY - GEN
T1 - Centella asiatica protect the development of aluminum-induced zebrafish larvae
AU - Supriadi, Rizky Febriyanti
AU - Permata, Tesza Rezky
AU - Norisa, Nanda
AU - Khotimah, Husnul
AU - Ali, Mulyohadi
AU - Widodo, M. Aris
AU - Kalsum, Umi
AU - Nurdiana,
N1 - Publisher Copyright:
© 2019 Author(s).
PY - 2019/6/4
Y1 - 2019/6/4
N2 - Aluminum (Al) is the most abundant metal in nature that is not known to perform a physiological function of the human organism. Accumulation of aluminum in the body can cause toxicity to development and growth in early life. The mechanism of Aluminum toxicity primarily by increasing oxidative stress and finally leads to cell death. Centella asiatica (CeA) as commonly consumed is a plant that has 84% antioxidant, but whether it is able to prevent developmental disruption due to oxidative stress aluminum-induced exposure has never been investigated. In this study, we examined the effect of ethanolic extract of CeA to teratogenicity, development, and growth in the early life of zebrafish. We observed the survival rate, hatching rate, body length, ossification of cartilage, heart rate and motility used zebrafish from 0 hpf (hour post fertilization) until 6 dpf (day post fertilization) which consist of 5 groups (control, AlCl3 50 μM, AlCl3+CeA 1,25 μg/ml, AlCl3+CeA 2,5 μg and AlCl3+CeA 5 μg/ml). We found that CeA significantly protects the toxicity of Aluminum in zebrafish larvae developmental and growth by protect the structure and physiology of the organ during embryonic development.
AB - Aluminum (Al) is the most abundant metal in nature that is not known to perform a physiological function of the human organism. Accumulation of aluminum in the body can cause toxicity to development and growth in early life. The mechanism of Aluminum toxicity primarily by increasing oxidative stress and finally leads to cell death. Centella asiatica (CeA) as commonly consumed is a plant that has 84% antioxidant, but whether it is able to prevent developmental disruption due to oxidative stress aluminum-induced exposure has never been investigated. In this study, we examined the effect of ethanolic extract of CeA to teratogenicity, development, and growth in the early life of zebrafish. We observed the survival rate, hatching rate, body length, ossification of cartilage, heart rate and motility used zebrafish from 0 hpf (hour post fertilization) until 6 dpf (day post fertilization) which consist of 5 groups (control, AlCl3 50 μM, AlCl3+CeA 1,25 μg/ml, AlCl3+CeA 2,5 μg and AlCl3+CeA 5 μg/ml). We found that CeA significantly protects the toxicity of Aluminum in zebrafish larvae developmental and growth by protect the structure and physiology of the organ during embryonic development.
KW - Aluminum
KW - body length
KW - Centella asiatica
KW - heart rate
KW - motility
UR - https://www.scopus.com/pages/publications/85067083680
U2 - 10.1063/1.5110005
DO - 10.1063/1.5110005
M3 - Conference contribution
AN - SCOPUS:85067083680
T3 - AIP Conference Proceedings
BT - International Conference on Bioinformatics and Nanomedicine from Natural Resources for Biomedical Research
A2 - Budianto, Windy Yuliana
A2 - Sujuti, Hidayat
A2 - Khotimah, Husnul
PB - American Institute of Physics Inc.
T2 - 3rd Annual Scientific Meeting of Indonesian Consortium for Biomedical Sciences, ASMICBS 2018
Y2 - 21 November 2018 through 23 November 2018
ER -