CA125 Level and the Presence of Ascites as the Neoadjuvant Chemotherapy Consideration for Advanced Ovarian Carcinoma

Tatit Nurseta; Putu Arik Herliawati; Dhian Eka Putri Harnandari; Kusworini Handono

doi:10.1063/5.0111731

CA125 Level and the Presence of Ascites as the Neoadjuvant Chemotherapy Consideration for Advanced Ovarian Carcinoma

Tatit Nurseta^*
, Putu Arik Herliawati
, Dhian Eka Putri Harnandari
, Kusworini Handono

^*Corresponding author for this work

Faculty of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

The shallow survival rate in patients with advanced stages ovarian carcinoma requires early diagnosis to improve treatment results. The aim of this study is to compare serum CA 125 levels (obtained from laboratory results) with the presence of ascites on ultrasound in patients with advanced epithelial ovarian carcinoma for consideration of Neoadjuvant Chemotherapy (NACT). This retrospective analytic observational study involved 106 samples from the last live years of carcinoma ovarian patients at the dr. Saiful Anwar Hospital in Malang Indonesia. The comparison of CA125 levels between ascites patients and patients without ascites, using the Mann-Whitney test, results in a p-value of 0.125. This finding shows no significant difference in CA125 levels between ascites patients and patients without ascites. This study indicates that the CA 125 level and presence of ascites can't be used in predicting the stage of Epithelial Ovarian Carcinoma. We believe that the level of CA 125 and the presence of ascites are not independent factors for diagnosing malignancy. Thus, the variables should not be considered for neoadjuvant chemotherapy.

Original language	English
Title of host publication	4th International Conference on Life Science and Technology, ICoLiST 2023
Editors	Ahmad Taufiq, Hendra Susanto, I. Ching Wang, Hadi Nur, Muhammad Aziz, Chuang-Rung Chang, Gereon Elbers, Sri Rahayu Lestari, Markus Diantoro, Nandang Mufti, Chen Siang Ng, Nik Ahmad Nizam Nik Malek, Sunaryono, Yu-Hsin Chiu, Siti Zubaidah, Aulanni'am, Indra Wibowo, Adeodatus Yuda Handaya
Publisher	American Institute of Physics Inc.
ISBN (Electronic)	9780735443136
DOIs	https://doi.org/10.1063/5.0111731
Publication status	Published - 24 Jan 2023
Event	4th International Conference on Life Science and Technology, ICoLiST 2023 - Virtual, Online, Indonesia Duration: 31 Aug 2021 → …

Publication series

Name	AIP Conference Proceedings
Volume	2634
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	4th International Conference on Life Science and Technology, ICoLiST 2023
Country/Territory	Indonesia
City	Virtual, Online
Period	31/08/21 → …

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1063/5.0111731

Cite this

Nurseta, T., Herliawati, P. A., Harnandari, D. E. P., & Handono, K. (2023). CA125 Level and the Presence of Ascites as the Neoadjuvant Chemotherapy Consideration for Advanced Ovarian Carcinoma. In A. Taufiq, H. Susanto, I. C. Wang, H. Nur, M. Aziz, C.-R. Chang, G. Elbers, S. R. Lestari, M. Diantoro, N. Mufti, C. S. Ng, N. A. N. N. Malek, Sunaryono, Y.-H. Chiu, S. Zubaidah, Aulanni'am, I. Wibowo, & A. Y. Handaya (Eds.), 4th International Conference on Life Science and Technology, ICoLiST 2023 Article 020055 (AIP Conference Proceedings; Vol. 2634). American Institute of Physics Inc.. https://doi.org/10.1063/5.0111731

Nurseta, Tatit ; Herliawati, Putu Arik ; Harnandari, Dhian Eka Putri et al. / CA125 Level and the Presence of Ascites as the Neoadjuvant Chemotherapy Consideration for Advanced Ovarian Carcinoma. 4th International Conference on Life Science and Technology, ICoLiST 2023. editor / Ahmad Taufiq ; Hendra Susanto ; I. Ching Wang ; Hadi Nur ; Muhammad Aziz ; Chuang-Rung Chang ; Gereon Elbers ; Sri Rahayu Lestari ; Markus Diantoro ; Nandang Mufti ; Chen Siang Ng ; Nik Ahmad Nizam Nik Malek ; Sunaryono ; Yu-Hsin Chiu ; Siti Zubaidah ; Aulanni'am ; Indra Wibowo ; Adeodatus Yuda Handaya. American Institute of Physics Inc., 2023. (AIP Conference Proceedings).

@inproceedings{e1d64b99445e407fb20b5ee330ee1e4a,

title = "CA125 Level and the Presence of Ascites as the Neoadjuvant Chemotherapy Consideration for Advanced Ovarian Carcinoma",

abstract = "The shallow survival rate in patients with advanced stages ovarian carcinoma requires early diagnosis to improve treatment results. The aim of this study is to compare serum CA 125 levels (obtained from laboratory results) with the presence of ascites on ultrasound in patients with advanced epithelial ovarian carcinoma for consideration of Neoadjuvant Chemotherapy (NACT). This retrospective analytic observational study involved 106 samples from the last live years of carcinoma ovarian patients at the dr. Saiful Anwar Hospital in Malang Indonesia. The comparison of CA125 levels between ascites patients and patients without ascites, using the Mann-Whitney test, results in a p-value of 0.125. This finding shows no significant difference in CA125 levels between ascites patients and patients without ascites. This study indicates that the CA 125 level and presence of ascites can't be used in predicting the stage of Epithelial Ovarian Carcinoma. We believe that the level of CA 125 and the presence of ascites are not independent factors for diagnosing malignancy. Thus, the variables should not be considered for neoadjuvant chemotherapy.",

author = "Tatit Nurseta and Herliawati, \{Putu Arik\} and Harnandari, \{Dhian Eka Putri\} and Kusworini Handono",

note = "Publisher Copyright: {\textcopyright} 2023 American Institute of Physics Inc.. All rights reserved.; 4th International Conference on Life Science and Technology, ICoLiST 2023 ; Conference date: 31-08-2021",

year = "2023",

month = jan,

day = "24",

doi = "10.1063/5.0111731",

language = "English",

series = "AIP Conference Proceedings",

publisher = "American Institute of Physics Inc.",

editor = "Ahmad Taufiq and Hendra Susanto and Wang, \{I. Ching\} and Hadi Nur and Muhammad Aziz and Chuang-Rung Chang and Gereon Elbers and Lestari, \{Sri Rahayu\} and Markus Diantoro and Nandang Mufti and Ng, \{Chen Siang\} and Malek, \{Nik Ahmad Nizam Nik\} and Sunaryono and Yu-Hsin Chiu and Siti Zubaidah and Aulanni'am and Indra Wibowo and Handaya, \{Adeodatus Yuda\}",

booktitle = "4th International Conference on Life Science and Technology, ICoLiST 2023",

}

Nurseta, T, Herliawati, PA, Harnandari, DEP & Handono, K 2023, CA125 Level and the Presence of Ascites as the Neoadjuvant Chemotherapy Consideration for Advanced Ovarian Carcinoma. in A Taufiq, H Susanto, IC Wang, H Nur, M Aziz, C-R Chang, G Elbers, SR Lestari, M Diantoro, N Mufti, CS Ng, NANN Malek, Sunaryono, Y-H Chiu, S Zubaidah, Aulanni'am, I Wibowo & AY Handaya (eds), 4th International Conference on Life Science and Technology, ICoLiST 2023., 020055, AIP Conference Proceedings, vol. 2634, American Institute of Physics Inc., 4th International Conference on Life Science and Technology, ICoLiST 2023, Virtual, Online, Indonesia, 31/08/21. https://doi.org/10.1063/5.0111731

CA125 Level and the Presence of Ascites as the Neoadjuvant Chemotherapy Consideration for Advanced Ovarian Carcinoma. / Nurseta, Tatit; Herliawati, Putu Arik; Harnandari, Dhian Eka Putri et al.
4th International Conference on Life Science and Technology, ICoLiST 2023. ed. / Ahmad Taufiq; Hendra Susanto; I. Ching Wang; Hadi Nur; Muhammad Aziz; Chuang-Rung Chang; Gereon Elbers; Sri Rahayu Lestari; Markus Diantoro; Nandang Mufti; Chen Siang Ng; Nik Ahmad Nizam Nik Malek; Sunaryono; Yu-Hsin Chiu; Siti Zubaidah; Aulanni'am; Indra Wibowo; Adeodatus Yuda Handaya. American Institute of Physics Inc., 2023. 020055 (AIP Conference Proceedings; Vol. 2634).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - CA125 Level and the Presence of Ascites as the Neoadjuvant Chemotherapy Consideration for Advanced Ovarian Carcinoma

AU - Nurseta, Tatit

AU - Herliawati, Putu Arik

AU - Harnandari, Dhian Eka Putri

AU - Handono, Kusworini

PY - 2023/1/24

Y1 - 2023/1/24

N2 - The shallow survival rate in patients with advanced stages ovarian carcinoma requires early diagnosis to improve treatment results. The aim of this study is to compare serum CA 125 levels (obtained from laboratory results) with the presence of ascites on ultrasound in patients with advanced epithelial ovarian carcinoma for consideration of Neoadjuvant Chemotherapy (NACT). This retrospective analytic observational study involved 106 samples from the last live years of carcinoma ovarian patients at the dr. Saiful Anwar Hospital in Malang Indonesia. The comparison of CA125 levels between ascites patients and patients without ascites, using the Mann-Whitney test, results in a p-value of 0.125. This finding shows no significant difference in CA125 levels between ascites patients and patients without ascites. This study indicates that the CA 125 level and presence of ascites can't be used in predicting the stage of Epithelial Ovarian Carcinoma. We believe that the level of CA 125 and the presence of ascites are not independent factors for diagnosing malignancy. Thus, the variables should not be considered for neoadjuvant chemotherapy.

AB - The shallow survival rate in patients with advanced stages ovarian carcinoma requires early diagnosis to improve treatment results. The aim of this study is to compare serum CA 125 levels (obtained from laboratory results) with the presence of ascites on ultrasound in patients with advanced epithelial ovarian carcinoma for consideration of Neoadjuvant Chemotherapy (NACT). This retrospective analytic observational study involved 106 samples from the last live years of carcinoma ovarian patients at the dr. Saiful Anwar Hospital in Malang Indonesia. The comparison of CA125 levels between ascites patients and patients without ascites, using the Mann-Whitney test, results in a p-value of 0.125. This finding shows no significant difference in CA125 levels between ascites patients and patients without ascites. This study indicates that the CA 125 level and presence of ascites can't be used in predicting the stage of Epithelial Ovarian Carcinoma. We believe that the level of CA 125 and the presence of ascites are not independent factors for diagnosing malignancy. Thus, the variables should not be considered for neoadjuvant chemotherapy.

UR - https://www.scopus.com/pages/publications/85147303666

U2 - 10.1063/5.0111731

DO - 10.1063/5.0111731

M3 - Conference contribution

AN - SCOPUS:85147303666

T3 - AIP Conference Proceedings

BT - 4th International Conference on Life Science and Technology, ICoLiST 2023

A2 - Taufiq, Ahmad

A2 - Susanto, Hendra

A2 - Wang, I. Ching

A2 - Nur, Hadi

A2 - Aziz, Muhammad

A2 - Chang, Chuang-Rung

A2 - Elbers, Gereon

A2 - Lestari, Sri Rahayu

A2 - Diantoro, Markus

A2 - Mufti, Nandang

A2 - Ng, Chen Siang

A2 - Malek, Nik Ahmad Nizam Nik

A2 - Sunaryono, null

A2 - Chiu, Yu-Hsin

A2 - Zubaidah, Siti

A2 - Aulanni'am, null

A2 - Wibowo, Indra

A2 - Handaya, Adeodatus Yuda

PB - American Institute of Physics Inc.

T2 - 4th International Conference on Life Science and Technology, ICoLiST 2023

Y2 - 31 August 2021

ER -

Nurseta T, Herliawati PA, Harnandari DEP, Handono K. CA125 Level and the Presence of Ascites as the Neoadjuvant Chemotherapy Consideration for Advanced Ovarian Carcinoma. In Taufiq A, Susanto H, Wang IC, Nur H, Aziz M, Chang CR, Elbers G, Lestari SR, Diantoro M, Mufti N, Ng CS, Malek NANN, Sunaryono, Chiu YH, Zubaidah S, Aulanni'am, Wibowo I, Handaya AY, editors, 4th International Conference on Life Science and Technology, ICoLiST 2023. American Institute of Physics Inc. 2023. 020055. (AIP Conference Proceedings). doi: 10.1063/5.0111731

CA125 Level and the Presence of Ascites as the Neoadjuvant Chemotherapy Consideration for Advanced Ovarian Carcinoma

Abstract

Publication series

Conference

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this