Antioxidant and cytotoxic activity of Acanthus ilicifolius flower

Muhamad Firdaus; Asep Awaludin Prihanto; Rahmi Nurdiani

doi:10.1016/S2221-1691(13)60017-9

Antioxidant and cytotoxic activity of Acanthus ilicifolius flower

Muhamad Firdaus
, Asep Awaludin Prihanto^*
, Rahmi Nurdiani

^*Corresponding author for this work

Faculty of Fisheries and Marine Sciences

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

Abstract

Objective: To investigate the antioxidant and cytotoxic activity of the flower of Acanthus ilicifolius (A. ilicifolius). Methods: Antioxidant activity was determined as antiradical efficiency with diphenyl picrylhydrazil (DPPH) method and cytotoxic assay was undertaken using brine shrimp lethal toxicity test. Results: A. ilicifolius flower contained terpenoid, phenolic compounds, and alkaloid. The methanol extract of A. ilicifolius flower showed the highest antiradical efficiency (AE=1.41×10^-3) against DPPH radicals and the highest cytotoxicity (LC₅₀=22 μg/mL) against brine shrimp nauplii. Conclusions: It is suggested that active compounds of A. ilicifolius flower solved in methanol play a role to inhibit free radical activity and kill Artemia salina nauplii. The substances can be considered as potential antioxidant and cytotoxic agents as well as imminent candidate for cancer therapy.

Original language	English
Pages (from-to)	17-21
Number of pages	5
Journal	Asian Pacific Journal of Tropical Biomedicine
Volume	3
Issue number	1
DOIs	https://doi.org/10.1016/S2221-1691(13)60017-9
Publication status	Published - Jan 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Acanthus ilicifolius
Antioxidant
Cytotoxic
Flower

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10.1016/S2221-1691(13)60017-9

Cite this

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title = "Antioxidant and cytotoxic activity of Acanthus ilicifolius flower",

abstract = "Objective: To investigate the antioxidant and cytotoxic activity of the flower of Acanthus ilicifolius (A. ilicifolius). Methods: Antioxidant activity was determined as antiradical efficiency with diphenyl picrylhydrazil (DPPH) method and cytotoxic assay was undertaken using brine shrimp lethal toxicity test. Results: A. ilicifolius flower contained terpenoid, phenolic compounds, and alkaloid. The methanol extract of A. ilicifolius flower showed the highest antiradical efficiency (AE=1.41{\texttimes}10-3) against DPPH radicals and the highest cytotoxicity (LC50=22 μg/mL) against brine shrimp nauplii. Conclusions: It is suggested that active compounds of A. ilicifolius flower solved in methanol play a role to inhibit free radical activity and kill Artemia salina nauplii. The substances can be considered as potential antioxidant and cytotoxic agents as well as imminent candidate for cancer therapy.",

keywords = "Acanthus ilicifolius, Antioxidant, Cytotoxic, Flower",

author = "Muhamad Firdaus and Prihanto, \{Asep Awaludin\} and Rahmi Nurdiani",

year = "2013",

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doi = "10.1016/S2221-1691(13)60017-9",

language = "English",

volume = "3",

pages = "17--21",

journal = "Asian Pacific Journal of Tropical Biomedicine",

issn = "2221-1691",

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T1 - Antioxidant and cytotoxic activity of Acanthus ilicifolius flower

AU - Firdaus, Muhamad

AU - Prihanto, Asep Awaludin

AU - Nurdiani, Rahmi

PY - 2013/1

Y1 - 2013/1

N2 - Objective: To investigate the antioxidant and cytotoxic activity of the flower of Acanthus ilicifolius (A. ilicifolius). Methods: Antioxidant activity was determined as antiradical efficiency with diphenyl picrylhydrazil (DPPH) method and cytotoxic assay was undertaken using brine shrimp lethal toxicity test. Results: A. ilicifolius flower contained terpenoid, phenolic compounds, and alkaloid. The methanol extract of A. ilicifolius flower showed the highest antiradical efficiency (AE=1.41×10-3) against DPPH radicals and the highest cytotoxicity (LC50=22 μg/mL) against brine shrimp nauplii. Conclusions: It is suggested that active compounds of A. ilicifolius flower solved in methanol play a role to inhibit free radical activity and kill Artemia salina nauplii. The substances can be considered as potential antioxidant and cytotoxic agents as well as imminent candidate for cancer therapy.

AB - Objective: To investigate the antioxidant and cytotoxic activity of the flower of Acanthus ilicifolius (A. ilicifolius). Methods: Antioxidant activity was determined as antiradical efficiency with diphenyl picrylhydrazil (DPPH) method and cytotoxic assay was undertaken using brine shrimp lethal toxicity test. Results: A. ilicifolius flower contained terpenoid, phenolic compounds, and alkaloid. The methanol extract of A. ilicifolius flower showed the highest antiradical efficiency (AE=1.41×10-3) against DPPH radicals and the highest cytotoxicity (LC50=22 μg/mL) against brine shrimp nauplii. Conclusions: It is suggested that active compounds of A. ilicifolius flower solved in methanol play a role to inhibit free radical activity and kill Artemia salina nauplii. The substances can be considered as potential antioxidant and cytotoxic agents as well as imminent candidate for cancer therapy.

KW - Acanthus ilicifolius

KW - Antioxidant

KW - Cytotoxic

KW - Flower

UR - https://www.scopus.com/pages/publications/84872810349

U2 - 10.1016/S2221-1691(13)60017-9

DO - 10.1016/S2221-1691(13)60017-9

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AN - SCOPUS:84872810349

SN - 2221-1691

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JO - Asian Pacific Journal of Tropical Biomedicine

JF - Asian Pacific Journal of Tropical Biomedicine

IS - 1

ER -

Antioxidant and cytotoxic activity of Acanthus ilicifolius flower

Abstract

UN SDGs

Keywords

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