Anticancer potential of Holothurin A, Holothurin B, and Holothurin B3 from the sea cucumber holothuria scabra

Teresa Liliana Wargasetia; Hana Ratnawati; Nashi Widodo

doi:10.1063/5.0002552

Anticancer potential of Holothurin A, Holothurin B, and Holothurin B3 from the sea cucumber holothuria scabra

Teresa Liliana Wargasetia^*
, Hana Ratnawati
, Nashi Widodo

^*Corresponding author for this work

Faculty of Mathematics and Natural Sciences

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

9 Citations (Scopus)

Abstract

Sea cucumbers have a wide distribution and high abundance in Indonesia. Previous research has shown that sea cucumbers have an anticancer function and have toxicity to various types of cancer cells. Furthermore, we identified the anticancer compounds of the sea cucumber Holothuria scabra collected from the South Malang sea. H. scabra was extracted using methanol, and then the active compound content was analyzed using liquid chromatography-mass spectrometry (LC-MS). From the results of the analysis, it is known that the methanol extract of H. scabra contains three types of anticancer compounds, namely holothurin A, holothurin B, and holothurin B3. Based on in silico analysis, it is estimated that the holothurin compounds have target proteins, namely BCL2, HDAC1, and PTPN2, which play an essential role in the process of apoptosis, cell cycle, and suppressing tumor. The results of this study show that sea cucumber might have anticancer, although various in vitro and in vivo tests are needed to prove the anticancer mechanism.

Original language	English
Title of host publication	International Conference on Life Science and Technology, ICoLiST 2019
Editors	Ahmad Taufiq, Hendra Susanto, Hadi Nur, Muhammad Aziz, Chuang-Rung Chang, Hyohyemi Lee, Markus Diantoro, Nandang Mufti, Nik Ahmad Nizam Nik Malek, I. Ching Wang, Djoko Tjahnono Iskandar, Gereon Elbers, Sunaryono Sunaryono, Siti Zubaidah, Sumari Sumari, Aulanni'am, Asep Bayu Nandiyanto, Indra Wibowo, Adeodatus Yuda Handaya
Publisher	American Institute of Physics Inc.
ISBN (Electronic)	9780735419902
DOIs	https://doi.org/10.1063/5.0002552
Publication status	Published - 21 Apr 2020
Event	2nd International Conference on Life Science and Technology, ICoLiST 2019 - Malang, East Java, Indonesia Duration: 12 Sept 2019 → 13 Sept 2019

Publication series

Name	AIP Conference Proceedings
Volume	2231
ISSN (Print)	0094-243X
ISSN (Electronic)	1551-7616

Conference

Conference	2nd International Conference on Life Science and Technology, ICoLiST 2019
Country/Territory	Indonesia
City	Malang, East Java
Period	12/09/19 → 13/09/19

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1063/5.0002552

Cite this

Wargasetia, T. L., Ratnawati, H., & Widodo, N. (2020). Anticancer potential of Holothurin A, Holothurin B, and Holothurin B3 from the sea cucumber holothuria scabra. In A. Taufiq, H. Susanto, H. Nur, M. Aziz, C.-R. Chang, H. Lee, M. Diantoro, N. Mufti, N. A. N. N. Malek, I. C. Wang, D. T. Iskandar, G. Elbers, S. Sunaryono, S. Zubaidah, S. Sumari, Aulanni'am, A. B. Nandiyanto, I. Wibowo, & A. Y. Handaya (Eds.), International Conference on Life Science and Technology, ICoLiST 2019 Article 2552 (AIP Conference Proceedings; Vol. 2231). American Institute of Physics Inc.. https://doi.org/10.1063/5.0002552

Wargasetia, Teresa Liliana ; Ratnawati, Hana ; Widodo, Nashi. / Anticancer potential of Holothurin A, Holothurin B, and Holothurin B3 from the sea cucumber holothuria scabra. International Conference on Life Science and Technology, ICoLiST 2019. editor / Ahmad Taufiq ; Hendra Susanto ; Hadi Nur ; Muhammad Aziz ; Chuang-Rung Chang ; Hyohyemi Lee ; Markus Diantoro ; Nandang Mufti ; Nik Ahmad Nizam Nik Malek ; I. Ching Wang ; Djoko Tjahnono Iskandar ; Gereon Elbers ; Sunaryono Sunaryono ; Siti Zubaidah ; Sumari Sumari ; Aulanni'am ; Asep Bayu Nandiyanto ; Indra Wibowo ; Adeodatus Yuda Handaya. American Institute of Physics Inc., 2020. (AIP Conference Proceedings).

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title = "Anticancer potential of Holothurin A, Holothurin B, and Holothurin B3 from the sea cucumber holothuria scabra",

abstract = "Sea cucumbers have a wide distribution and high abundance in Indonesia. Previous research has shown that sea cucumbers have an anticancer function and have toxicity to various types of cancer cells. Furthermore, we identified the anticancer compounds of the sea cucumber Holothuria scabra collected from the South Malang sea. H. scabra was extracted using methanol, and then the active compound content was analyzed using liquid chromatography-mass spectrometry (LC-MS). From the results of the analysis, it is known that the methanol extract of H. scabra contains three types of anticancer compounds, namely holothurin A, holothurin B, and holothurin B3. Based on in silico analysis, it is estimated that the holothurin compounds have target proteins, namely BCL2, HDAC1, and PTPN2, which play an essential role in the process of apoptosis, cell cycle, and suppressing tumor. The results of this study show that sea cucumber might have anticancer, although various in vitro and in vivo tests are needed to prove the anticancer mechanism.",

author = "Wargasetia, \{Teresa Liliana\} and Hana Ratnawati and Nashi Widodo",

note = "Publisher Copyright: {\textcopyright} 2020 American Institute of Physics Inc.. All rights reserved.; 2nd International Conference on Life Science and Technology, ICoLiST 2019 ; Conference date: 12-09-2019 Through 13-09-2019",

year = "2020",

month = apr,

day = "21",

doi = "10.1063/5.0002552",

language = "English",

series = "AIP Conference Proceedings",

publisher = "American Institute of Physics Inc.",

editor = "Ahmad Taufiq and Hendra Susanto and Hadi Nur and Muhammad Aziz and Chuang-Rung Chang and Hyohyemi Lee and Markus Diantoro and Nandang Mufti and Malek, \{Nik Ahmad Nizam Nik\} and Wang, \{I. Ching\} and Iskandar, \{Djoko Tjahnono\} and Gereon Elbers and Sunaryono Sunaryono and Siti Zubaidah and Sumari Sumari and Aulanni'am and Nandiyanto, \{Asep Bayu\} and Indra Wibowo and Handaya, \{Adeodatus Yuda\}",

booktitle = "International Conference on Life Science and Technology, ICoLiST 2019",

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Wargasetia, TL, Ratnawati, H & Widodo, N 2020, Anticancer potential of Holothurin A, Holothurin B, and Holothurin B3 from the sea cucumber holothuria scabra. in A Taufiq, H Susanto, H Nur, M Aziz, C-R Chang, H Lee, M Diantoro, N Mufti, NANN Malek, IC Wang, DT Iskandar, G Elbers, S Sunaryono, S Zubaidah, S Sumari, Aulanni'am, AB Nandiyanto, I Wibowo & AY Handaya (eds), International Conference on Life Science and Technology, ICoLiST 2019., 2552, AIP Conference Proceedings, vol. 2231, American Institute of Physics Inc., 2nd International Conference on Life Science and Technology, ICoLiST 2019, Malang, East Java, Indonesia, 12/09/19. https://doi.org/10.1063/5.0002552

Anticancer potential of Holothurin A, Holothurin B, and Holothurin B3 from the sea cucumber holothuria scabra. / Wargasetia, Teresa Liliana; Ratnawati, Hana; Widodo, Nashi.
International Conference on Life Science and Technology, ICoLiST 2019. ed. / Ahmad Taufiq; Hendra Susanto; Hadi Nur; Muhammad Aziz; Chuang-Rung Chang; Hyohyemi Lee; Markus Diantoro; Nandang Mufti; Nik Ahmad Nizam Nik Malek; I. Ching Wang; Djoko Tjahnono Iskandar; Gereon Elbers; Sunaryono Sunaryono; Siti Zubaidah; Sumari Sumari; Aulanni'am; Asep Bayu Nandiyanto; Indra Wibowo; Adeodatus Yuda Handaya. American Institute of Physics Inc., 2020. 2552 (AIP Conference Proceedings; Vol. 2231).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Anticancer potential of Holothurin A, Holothurin B, and Holothurin B3 from the sea cucumber holothuria scabra

AU - Wargasetia, Teresa Liliana

AU - Ratnawati, Hana

AU - Widodo, Nashi

PY - 2020/4/21

Y1 - 2020/4/21

N2 - Sea cucumbers have a wide distribution and high abundance in Indonesia. Previous research has shown that sea cucumbers have an anticancer function and have toxicity to various types of cancer cells. Furthermore, we identified the anticancer compounds of the sea cucumber Holothuria scabra collected from the South Malang sea. H. scabra was extracted using methanol, and then the active compound content was analyzed using liquid chromatography-mass spectrometry (LC-MS). From the results of the analysis, it is known that the methanol extract of H. scabra contains three types of anticancer compounds, namely holothurin A, holothurin B, and holothurin B3. Based on in silico analysis, it is estimated that the holothurin compounds have target proteins, namely BCL2, HDAC1, and PTPN2, which play an essential role in the process of apoptosis, cell cycle, and suppressing tumor. The results of this study show that sea cucumber might have anticancer, although various in vitro and in vivo tests are needed to prove the anticancer mechanism.

AB - Sea cucumbers have a wide distribution and high abundance in Indonesia. Previous research has shown that sea cucumbers have an anticancer function and have toxicity to various types of cancer cells. Furthermore, we identified the anticancer compounds of the sea cucumber Holothuria scabra collected from the South Malang sea. H. scabra was extracted using methanol, and then the active compound content was analyzed using liquid chromatography-mass spectrometry (LC-MS). From the results of the analysis, it is known that the methanol extract of H. scabra contains three types of anticancer compounds, namely holothurin A, holothurin B, and holothurin B3. Based on in silico analysis, it is estimated that the holothurin compounds have target proteins, namely BCL2, HDAC1, and PTPN2, which play an essential role in the process of apoptosis, cell cycle, and suppressing tumor. The results of this study show that sea cucumber might have anticancer, although various in vitro and in vivo tests are needed to prove the anticancer mechanism.

UR - https://www.scopus.com/pages/publications/85092580185

U2 - 10.1063/5.0002552

DO - 10.1063/5.0002552

M3 - Conference contribution

AN - SCOPUS:85092580185

T3 - AIP Conference Proceedings

BT - International Conference on Life Science and Technology, ICoLiST 2019

A2 - Taufiq, Ahmad

A2 - Susanto, Hendra

A2 - Nur, Hadi

A2 - Aziz, Muhammad

A2 - Chang, Chuang-Rung

A2 - Lee, Hyohyemi

A2 - Diantoro, Markus

A2 - Mufti, Nandang

A2 - Malek, Nik Ahmad Nizam Nik

A2 - Wang, I. Ching

A2 - Iskandar, Djoko Tjahnono

A2 - Elbers, Gereon

A2 - Sunaryono, Sunaryono

A2 - Zubaidah, Siti

A2 - Sumari, Sumari

A2 - Aulanni'am, null

A2 - Nandiyanto, Asep Bayu

A2 - Wibowo, Indra

A2 - Handaya, Adeodatus Yuda

PB - American Institute of Physics Inc.

T2 - 2nd International Conference on Life Science and Technology, ICoLiST 2019

Y2 - 12 September 2019 through 13 September 2019

ER -

Wargasetia TL, Ratnawati H, Widodo N. Anticancer potential of Holothurin A, Holothurin B, and Holothurin B3 from the sea cucumber holothuria scabra. In Taufiq A, Susanto H, Nur H, Aziz M, Chang CR, Lee H, Diantoro M, Mufti N, Malek NANN, Wang IC, Iskandar DT, Elbers G, Sunaryono S, Zubaidah S, Sumari S, Aulanni'am, Nandiyanto AB, Wibowo I, Handaya AY, editors, International Conference on Life Science and Technology, ICoLiST 2019. American Institute of Physics Inc. 2020. 2552. (AIP Conference Proceedings). doi: 10.1063/5.0002552

Anticancer potential of Holothurin A, Holothurin B, and Holothurin B3 from the sea cucumber holothuria scabra

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