Anti-methicillin resistant Staphylococcus aureus (MRSA) of methanol extract of mangrove plants leaf: Preliminary report

Increasing multidrug resistant (MTDR) in bacteria, in particular Staphylococcus aureus has been becoming worst. Finding new antibiotic source for MTDR is compulsion for scientist and clinicians due to the limitation of the therapeutic option. This research was conducted to investigate the antibacterial activity of methanol extracts of Sonneratia caseolaris, Acanthus ilicifolius, Rhizophora mucronata and Excoecaria agallocha against methicillin resistant, clinical isolates of Staphylococcus aureus using disk diffusion method. The minimum inhibitory concentration (MIC) values of all methanolic mangrove leaves ranged from 6 to 20 mg/mL. The mangrove leaf of Excoecaria agallocha possessed higher anti MRSA potency than the other mangrove plants. It is clear that mangrove leaves especially, E. agallocha leaf has anti MRSA compound. Further purification of active compound from the potent mangrove will be useful for the control of drug resistant strains of S. aureus.