Abstract
Objective: The study examined the effects of Aloe vera ethanol extract on alveolar mandible regeneration in rats (Rattus norvegicus). Methods: Rats were divided into five groups as follows: Negative control group received no treatment, positive control group received Escherichia coli lipopolysaccharide (LPS) alone for 5 days, and Groups P1, P2, and P3 received LPS for 5 days followed by 40, 80, and 160 mg/kg BW A. vera ethanol extract, respectively, orally on days 6-12. Alveolar bone tissues were taken and histologically processed through hematoxylin-eosin staining. Osteoblast and osteoclast numbers in alveolar tissue were also examined. Results: One-way ANOVA revealed strong relationships between the A. vera ethanol extract dosage and the numbers of osteoblasts (r=0.921, p<0.05) and osteoclasts (r=-0.631, p<0.05) in rats. Conclusion: A. vera ethanol extract appears capable of stimulating alveolar bone regeneration following LPS exposure.
| Original language | English |
|---|---|
| Pages (from-to) | 11-14 |
| Number of pages | 4 |
| Journal | International Journal of Applied Pharmaceutics |
| Volume | 10 |
| Issue number | Special Issue 1 |
| DOIs | |
| Publication status | Published - Dec 2018 |
Keywords
- Aloe chinensis
- Alveolar bone
- Baker ethanol extract
- Lipopolysaccharide
- Osteoblasts
- Osteoclasts
Fingerprint
Dive into the research topics of 'Aloe Vera ethanol extract as a therapy for alveolar mandible regeneration in lipopolysaccharide-exposed rats'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver