Acute Toxicity of Cinnamaldehyde in Profile Hematology and Gill Histology of Zebrafish

In this research, acute toxicity (LC₅₀) of cinnamaldehyde and its effect on hematology profile, as well as gill histology, in zebrafish were conducted. Briefly, 4-5 cm zebrafish were exposed to the following cinnamaldehyde concentrations: 0; 1.8; 2.4; 3.2; 4.2; 6.5; or 8.7 ppm for 96 hours. The results showed that cinnamaldehyde affected the hematology of zebrafish by increasing significantly the micronuclei and blood glucose at a concentration of 8,7 ppm (21 cells/mm³ and 193 mg/dL, respectively). Interestingly, the total leukocyte and the phagocytosis increased significantly at the concentration of 4.2 ppm of cinnamaldehyde.. Furthermore, cinnamaldehyde promotes edema, and hyperplasia in the gill structure tissue was observed at the concentrations 4.2, 6.5, and 8.7 ppm with total damage around 1%, 11%, and 45%, respectively. Cinnamaldehyde has acute toxicity LC₅₀ at concentration 7.2 ppm and up to that certain concentration promotes tissue health in the aquatic organism.